DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and ptr-14

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_501963.1	Gene:	ptr-14 / 177951	WormBaseID:	WBGene00004228	Length:	877	Species:	Caenorhabditis elegans

Alignment Length:	911	Identity:	225/911 - (24%)
Similarity:	394/911 - (43%)	Gaps:	135/911 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GISCVD-----KTLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAG 63
            |.|.:|     :.||:.|...|:.:|.:....:|:.:|||..|.:.....|.:.|.:..::|:..
Worm     3 GASALDPPAFVRLLNRLFRQCGLFVADNDKAVLIVTLLLTAFCSSKICFTKQEDDIKTGYTPVGA 67

  Fly    64 EGKTERAIVEQYFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQNA 128
            ....|..:...:|            .:........:.||...:.:|......:|:..:.:.: .:
Worm    68 RSLDEIEVFSDFF------------ASTGDPIAVFLFITAKDNSSMADYNTMKEVVDIMDYV-GS 119

  Fly   129 TTTYDGDT-YTY-KDNCARWENE---CFENDILNLDALMDDIEAGQLNLTFPFMFNPVTWDAHLF 188
            ..|:.|:: ||. .|.|.  .||   .:.|.:......:.:: ..:..|||| |...:..:..|.
Worm   120 NLTHKGESFYTLCTDFCQ--INEPVRQYYNGLAMKQQNLSEV-GSRFQLTFP-MMQVLGKELDLS 180

  Fly   189 PVFFGGTKLTEDNYV--ISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNAENSGQFKH--- 248
            |.|| |.|..||..|  :.:..:|:...:..|.|::||  ||:|    |::      .|:.|
Worm   181 PNFF-GVKTDEDGNVEYVKIIMLQIRANIPNDWKKEDA--AEYE----RMI------SQYFHFKY 232

  Fly   249 ---------ISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRS-----KP 299
                     :|::|...     |:.:...|:.|:....|::|..|||||.....:...     |.
Worm   233 DSTHVTPLAMSLTYTGD-----EVVRTGLTIFPFIGVGFIIMTTFSIITIYYSSSRLDQWSVHKV 292

  Fly   300 FLGLMGNVSAIMATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAK---MP 361
            ...::..|..::||.:|.|...:.|..|..|....|||::.||:||.::.:....|..|:   |.
Worm   293 SEAILACVCPLLATSSALGTLFWFGFRFGTILCVTPFLILAIGVDDAYLQVHACMRLTAEDSSMT 357

  Fly   362 VAERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMA 426
            ..|::..|:.|...||.|||:|:..:||:||.:|...:.:||..:..|:.|.|::.||.:.|.::
Worm   358 KREKIARMLVEVGPSIAITSMTNLFAFLVGIYTPTPEISLFCAGNAVAILFDFIYQITMYTAILS 422

  Fly   427 ISGYRE-RKNLHSIFGCRVQPMSVAIKEKRNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDK 490
            |....| |||              |.|.|                  |:.:..|:....... |.
Worm   423 ICENLEMRKN--------------ATKRK------------------DSGLSFKNEQFTVML-DS 454

  Fly   491 MAAVINNKWCKAIIILAFASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYR 555
            ....:.|.:...:::..|..|:..:..|...|...|...||...||..::.....|.:.......
Worm   455 YCDWVANAYTHLLVLFCFIVYIFVSIRGALNINIILSPDKLVIGDSPLLQVNYLRDQFVLPNYTT 519

  Fly   556 MQVIIAGPLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLERNNELLNVTVDDE- 619
            :.:.:..|.|.:.....:.:.:|..:.|.......::::..::|.:.||.|.:.|.:.:..|:|
Worm   520 VNIFVQNPGNLTIQSNLDYMNSLFDSFESYPECLGKKFSHYFVRDYESFRESSLEEMEMMEDEEG 584

  Fly   620 -------QTFIDAVK---------EHWLFPGNPFSLDVRFNEDETQIIASRFLIQAVN---ITDT 665
                   :.|..|..         :||    |.|   |:|  |:..:::..:...:.:   :.|.
Worm   585 DTNKTALEPFSKAAMSEFLAWPEFQHW----NGF---VKF--DKNGMLSKYWATVSYHGEGLGDF 640

  Fly   666 NHEKEMVRDLRQICKD-SPLNASIFHPYFVFFDQFELVRPVSLQAMVIGAIIMMIISFVFIPNIL 729
            ...:.|:...|..... :|||.|||..|..|.|..|.:.|.::...|...|.|||:.|:|:.|:.
Worm   641 QVRRRMLNRWRATADQFAPLNVSIFDDYAPFVDTLETILPATISTSVCTLICMMIVCFLFMYNVF 705

  Fly   730 CSLWVAFSVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTY----MSSKKRSP 790
            .......::.||.:||.|::::|.::||.|||..|||.|||||||.|||.:.|    :...:.:|
Worm   706 TVFVATLAITSICIGVFGFLSMWGIDLDPISMACLIMSIGFSVDFPAHITFHYFREGLHDPQSTP 770

  Fly   791 KARVREALHSLGLPIIQGSSSTILGIVALLLAQSYIFLVFFKMVFLVIFFGAMHGLFLLPVLLSL 855
            ..||..:|.::|.|::|...||||.::.||...:|:..||.|.:.||:..|.:||||::|..|..
Worm   771 AKRVARSLAAIGFPLLQCGLSTILFVLCLLFVPTYMGEVFVKTMILVVTLGLIHGLFIVPAFLCA 835

  Fly   856 F 856
            |
Worm   836 F 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	204/844 (24%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	46/155 (30%)
ptr-14	NP_501963.1	Patched	44..838	CDD:308203	213/870 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1934
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10796
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880