Protein Alignment Ptr and F43D9.1

DIOPT Version :9

• Sequence 1: NP_001246145.1
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_499313.2
• Gene: F43D9.1 / 176469
• WormBaseID: WBGene00009653
• Length: 1226
• Species: Caenorhabditis elegans
• Alignment Length: 1238
• Identity: 248/1238 - (20%)
• Similarity: 444/1238 - (35%)
• Gaps: 301/1238 - (24%)

  Fly    12 LNKSFYHLGICIAKHPGYFIIIPVLLTLLCM-TGYQQLKYQIDPEYL-----FSPIAGEGKTERA 70
            |.::|:.||..||.|.    |:.:|:.|||. |.:  :...:..|:|     ||.|.|   ::..
 Worm   197 LRRTFWALGKFIANHK----IVSILVALLCFATAF--ILPTLHKEHLYIDLPFSHILG---SDSD 252

  Fly    71 IVE---------QYFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQ 126
            ::.         |.|. :....|:..:.....||. |::.|....:.::|::.......|...:.
 Worm   253 VISNGIGISPKMQEFN-SSNPAFSCMKWRDSNRFA-VLLRTMASRDTILRKDAVLAYTALKKKLD 315

  Fly   127 NATTTYDGDTYTYKDNCARWENECFENDILNLDALMDDIEAGQLNLTFPFMFNPVTWDA-HLFPV 190
            :    :..:...:...|:.   || |.|...:|.::.  ::.|:.||:|..|..::.|: :|..|
 Worm   316 H----FPVEKREFMTQCSL---EC-ETDKDMVDRIIK--KSPQVALTYPETFVSMSKDSTNLTRV 370

  Fly   191 FFG---GTKLTEDNYVISVPAIQLVYFVTADTKRQDAKGAE---W-----EETFLRVVGNAENSG 244
            :.|   |...|:.:..||.....|:.|...|    |..|.|   |     ::|.|....|
 Worm   371 YLGAAIGGVETDTDGAISKATSLLMNFELKD----DLTGKEHNSWHRHFEDQTRLTAASN----- 426

  Fly   245 QFKHISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMG----DAVRSKPFLGLMG 305
                ||:..::..|....:..:.|.  .|:...|.::.||  :.|.:|    :|.:|||.||:|.
 Worm   427 ----ISLMSWSPETFKDTVVASLKD--QYWCLQFCVIILF--VFCFLGSFGINAYQSKPCLGIMI 483

  Fly   306 NVSAIMATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRR-TKAKMPVAERMGLM 369
            .::.::.::....:..|..:....:.....|:.||||:...|.:...|.| :.|.:...|::..:
 Worm   484 FITLVVGSITGLSMQFYRDLPVDPLVYPICFVTIGIGLLWLFQLQFSWSRYSSAAVHPTEKIAFI 548

  Fly   370 MSEAAVSITITSVTDFISFL---------------IGIISPFRSVRIFCTYSVFAVCFTFLWHIT 419
            ::..|..|..::|...::||               :||.|   ||.|...::||
 Worm   549 LAHDAPGIAASAVVIVLTFLAMGAAIQNGHMVSSFLGIAS---SVAILLVFTVF----------- 599

  Fly   420 FFAACMAISGYRERKNLHSIFGCRVQPMSVAIKEKRNFLYKAIMAGGIDANDPDNPIDNKDHMLM 484
            |.:..:.|.|.||.:.:.                    .|:....|......|.  :.:.|...:
 Worm   600 FISVFVFIGGSREARGVK--------------------WYQIFKTGDTHFTAPQ--LASFDSASL 642

  Fly   485 AFFKDKM------------AAVINNKWCKAIIILAFASYLVGACYGITQIKEGLERRKLSREDSY 537
            ....|::            |.||:.|....||:|..| |:..|.||.......::........|.
 Worm   643 FSLHDRLLDARPCASRAVGAFVISPKIRYPIIMLCTA-YVFFAIYGFYNTGIDIKEEYFLPAGSS 706

  Fly   538 SVEFFDREDDYYREFPYRMQVIIAGPLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFL 602
            ...|.::..|.:.:....:::.|...:.|.|..||..:.::........|.|.   ..:||..|.
 Worm   707 EKSFIEQYRDQFGKTTQFVELTIESSIEYHDHEVQNNIFDIMDFAIAEGYATR---AVNWLAEFA 768

  Fly   603 SFLERNNELLNVTVDDEQTFIDAVKEHWLFPG---NPFSLDVRFNEDETQIIASRFLI------- 657
            .|  ....:.:|..|   ||:..|...:| |.   ..::.|:..:..:||||.||..:
 Worm   769 KF--EKASIYDVNPD---TFVPVVNLVFL-PSETYRKYTSDIVMDRFQTQIIKSRMYLELTAKGF 827

  Fly   658 -QAVNITDTNHEKEMVRDLRQICKDSPLNASIFHPYFVFFDQFELVRPVSLQAMVIGAIIMMIIS 721
             :..:..||..:|...:.: .:..|.|.:.|:.|...||..        .:.|..:..:::..:|
 Worm   828 AERTSFVDTILKKAAAKGI-PLSVDIPSSMSLRHDISVFTS--------GMLAFGVAIVMLFFVS 883

  Fly   722 FVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDSISMI-----NLIMCIGFSVDFTAHICYT 781
            .:.:.....::.:..:.|::.....||...|.|.::.:::.     |.:.|:     .....||:
 Worm   884 LLLLGQPALTVMLLITSIAVLGETVGYAYFWSVPMNIVTLTMALAGNALTCV-----IVIAFCYS 943

  Fly   782 YMSSKKRSPKA--RVREALHSLGLPIIQGSSSTILGIVALLLAQSYIFLVFFKMVFLVIFFGAMH 844
            |..|.|...:|  |::....:..:|::......:|..:.||.....:....||:|.|......:|
 Worm   944 YSMSGKSQIRAGVRIQYTFQATLVPVLFACIVPVLTFLPLLYVDVPVVNHLFKIVVLNATASLIH 1008

  Fly   845 GLFLLPVLLSLFGPG---SCLTWTGKDDGSDAEVDDGLDDRQLEKPFSQSYYMQYPSIGINGPYG 906
            .||.||.::..|...   ||.::      ..||:...:||.      |..||:         |.|
 Worm  1009 YLFFLPNMMLAFSERFGFSCTSF------QCAELCCDMDDE------SSIYYI---------PTG 1052

  Fly   907 SK-----GFLGAPYKAYGVDEKDLGLGTSGEDSSESSSSRSQHRQQAAATEEEVVVRESPTRRYD 966
            .:     |....|...|.|.:..:.                      |.....:.:...|.
 Worm  1053 GRAIHPEGLYHHPSYTYTVPKPLMN----------------------APPPHYLAIAAPPV---- 1091

  Fly   967 DGWRRSSYQNIYGQGAAQFQAQPDLYGKQVSATEWRQRLDTHEQQQRQRQRRSPFENYRQDVEID 1031
                    .:||||                  ||:..|   .|.::..|:.|...|:...:.|.|
 Worm  1092 --------NSIYGQ------------------TEYTSR---GEMKRVSRRNRRHSESSIGETEND 1127

  Fly  1032 MQKARRNSHGDVIDLHGTPNSSVEERFRRRGEPFSAESGDDSSYRHQQIMAMPAAGSAPSAKRYH 1096
                            |||....|.|.||:..   |.|.|...|.           ..||.
 Worm  1128 ----------------GTPGRDRESRRRRQRR---AVSRDSEIYE-----------DLPSP---- 1158

  Fly  1097 RRRSSEDSTSRHQRWPANIEERRARRAYSPAHN-RPETALTSYAYRSSSHHNLYQPNGKSSKYP- 1159
            |..:|..|||..::.|.::  ||....:|.:.| ||:    ::.|...:....|........||
 Worm  1159 RAVNSSRSTSPRRQQPGSM--RRPNNHHSGSQNPRPQ----AFHYDEGAQWRPYVQPSPYMFYPG 1217

  Fly  1160 PTY 1162
            |.|
 Worm  1218 PVY 1220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	168/867 (19%)
		Sterol-sensing	295..442	CDD:289145	35/162 (22%)
F43D9.1	NP_499313.2	Patched	328..1021	CDD:355433	158/775 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1934
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810