Protein Alignment Ptr and ptr-20

DIOPT Version :10

• Sequence 1: NP_610209.2
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_497114.1
• Gene: ptr-20 / 175165
• WormBaseID: WBGene00004234
• Length: 860
• Species: Caenorhabditis elegans
• Alignment Length: 907
• Identity: 228/907 - (25%)
• Similarity: 394/907 - (43%)
• Gaps: 134/907 - (14%)

  Fly    10 KTLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTERAIVE- 73
            :.|.:.|...|..:|:.|.:||:||.|||:|...|:.....|.|...:::|..|..:.|.|.::
 Worm     2 RKLERFFDWYGQFVARKPFFFILIPSLLTILSTYGFLSFHTQDDIWDIYAPTNGLSRVEEAGIKR 66

  Fly    74 -QYFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQNATTTYDGDTY 137
             :|...::.||..             |:::|....|::..|...|:.|....:.:..|.:||..:
 Worm    67 FEYASGSHHHRMQ-------------ILVSKKNRGNILTNEALGEVSQAHKFVADNITAFDGTRH 118

  Fly   138 -TYKDNCARWENECFENDILNLDALMDDIEAGQLNLTFPFMFNPVTWDAHLFPVFFGGTKLTEDN 201
             .||:.|..:.|:.....:..|.|.::|.......||||   |.......:|..:..|....|..
 Worm   119 IAYKNLCGVYCNDSNAAVLAFLQATLNDTSRSSFKLTFP---NAEALQKKIFVGYSLGDLKIEKG 180

  Fly   202 YVISVPAIQLVYFVTADTKRQDAKGAEWE---ETFLRVVGNAENSGQFKHISVSYFASRTLDHEL 263
            ||.....:.|.|.|........|...::|   ..|...:.:..:     ||..|.. |||  .||
 Worm   181 YVTEAKMVVLHYMVDTSIPNGRALATDFENKVRAFFASISDLSH-----HIKYSVL-SRT--REL 237

  Fly   264 EKN---TKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIMATLAAFGLAMYCGI 325
            |:.   |.|.:|:...|.:::..|.::|.:......|:.:..::|.:|..||.....||....|.
 Worm   238 EEQRAITITSLPFLGLTIVVLTCFMLVTLVRFPLYTSQHWQSIVGVLSPGMALWTTTGLLWGIGY 302

  Fly   326 EFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAVSITITSVTDFISFLI 390
            .|..|....|||::.|||||.|::|||||::.....:..|:|..::.:..|:|:|||||...|..
 Worm   303 PFSNILTVVPFLVVTIGIDDAFLILAGWRQSTKGESLEVRLGQSVAISGASVTVTSVTDVACFAT 367

  Fly   391 GIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRE---RKNLHSIFGCRVQPMSVAIK 452
            |:.|....|::||.|:..|:...|::.:|||.|.:.|...::   .|.|     .:.:|.....|
 Worm   368 GLFSNMPVVQLFCLYTTVALAIDFIYQMTFFTALVGIFVRKQVDIEKEL-----VKNEPKIEKTK 427

  Fly   453 EKRNFLYKAIMAGGIDAND--------PDNPIDNKDHMLMAFFKDKMAAVINNKWCKAIIILAFA 509
            |:.          |..::.        |....:.....::..|.|    .::....|..::|||.
 Worm   428 EEE----------GASSSSLASLLTFVPTISQEAHTRSILEVFID----FLHTPVAKLAVVLAFI 478

  Fly   510 SYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPY-----RMQVIIAG------- 562
            .::: .|..:.               |:....||.|:.|..:.|.     |||..:.|
 Worm   479 GHIL-ICLALV---------------SHVNTNFDMENLYLEDSPLTDISRRMQNFVLGEAFVVNF 527

  Fly   563 ---PL-NYSDPLVQEQVENLTSTLE-HTSYVTSRRYTESWLRSF---LSFLERNNELLNVTVDDE 619
               |: ::.|..::.:.|.:..:|| ...|...:..|..|:|.:   ::|.....:..:     :
 Worm   528 GVYPMPDFDDEQIRLKFEEMVKSLETMPKYGAGKENTNLWIREYSNAVAFWGETEDFWH-----K 587

  Fly   620 QTFIDAVKEHWLFPGNPFSLDVRF-------NEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQ 677
            :..::..:|        :.:|.::       |.||. |....|.|...|.|:....:..:.|.|.
 Worm   588 EDMVNNYRE--------YGMDEKYVTMTNDTNGDEI-IDGFFFTITYRNFTNFLEVESFLEDRRD 643

  Fly   678 ICKDSPLNASIF--HPYFVFFDQFELVRPVSLQAMVIGAIIMM-IISFVFIPNILCSLWVAFSVI 739
            |.|:......:|  ||:.....:.....|.:..:..:.|:::| ::..|||.|....:.||.|::
 Worm   644 ILKNYSTYFKVFSHHPFEKVPTESAASAPFNFISTSVSAVVLMSLLVLVFIMNFEAIISVAVSIV 708

  Fly   740 SIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYM-----------SSKKRSPKAR 793
            ||.||:..|:.||:||||::|:|:::|.||||||::||:||.|.           |......:.|
 Worm   709 SICLGIVVYLHLWNVNLDAVSLISMLMSIGFSVDYSAHVCYHYFAHVHEDEQLWRSHNYAETRDR 773

  Fly   794 VREALHSLGLPIIQGSSSTILGIVALLLAQSYIFLVFFKMVFLVIFFGAMHGLFLLPVLLSL 855
            :......:..|::|...|||||:..|:..::|:..||:|.|.||...|.:|.|.||||:..|
 Worm   774 LLSTFRGVAWPVMQSGLSTILGMFPLMFVRAYVVAVFWKTVILVGILGMLHALILLPVIFIL 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_610209.2	Patched	53..845	CDD:308203	206/852 (24%)
ptr-20	NP_497114.1	Patched	42..835	CDD:308203	213/865 (25%)