DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and ptr-6

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_494986.2	Gene:	ptr-6 / 173898	WormBaseID:	WBGene00004221	Length:	982	Species:	Caenorhabditis elegans

Alignment Length:	979	Identity:	270/979 - (27%)
Similarity:	447/979 - (45%)	Gaps:	155/979 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTCGISCVDKTLNKSF----YHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLK--YQIDPEYLFS 59
            |.|.|..:||.|.|.|    .||   :..:...|:|.||:||.:|..|:..:|  ..:|...|::
Worm     1 MRCRIPTLDKKLEKVFAWYTKHL---LVDYYYVFLIAPVILTAICSCGFYWIKELTLLDARKLYT 62

  Fly    60 PIAGEGKTERAIVEQYFKV--------------NYTHRFNVGRITRPGRFGRVI----------- 99
            |::.....|..:..:.:.|              .|.:....||....|.:..::
Worm    63 PVSAPSWKEEQVFSELWPVKSYEFLPERTFQWNRYLYLVVHGRPYENGTYPNILEGSYLNDIAKI 127

  Fly   100 ---VIT----------KDGDENMIRREVFQ-ELRQLDNIIQNATTTYDGDTYTYKDNCARWENEC 150
               ::|          :|....|.:|.:.: |:.:..||           |.|:||.|..|..:|
Worm   128 EEELVTNVSFPREAALEDNPALMRKRHLNETEIEENRNI-----------TITFKDVCMNWYGDC 181

  Fly   151 F-ENDILNLDALMDDIEAGQLNLTFPFMFNPVTWDAHLFPVF----FGGTKLTEDNYVISVPAIQ 210
            : |.:::.|.....::....:::|||.:....|      |::    .||.....::.:....|::
Worm   182 YREKNVIELLKRRHELNKRGISVTFPQVNQEGT------PIYIAFVIGGVDTYPNDTIKYARAMR 240

  Fly   211 LVYFVTADTKRQDAKGAEWEET---FLRVVGNAENSGQFKHISVSYFASRTLDHELEKNTKTVVP 272
            |.||:..|.:.|:.....||:|   |:|     |.......|......||.:|..|.:|...:.|
Worm   241 LWYFLKFDDEEQEQLAKFWEDTAEKFVR-----ETYADHPTIQCHIKHSRIVDQGLTRNANRLKP 300

  Fly   273 YFSSTFLLMGLFSIITCMMG------------DAVRSKPFLGLMGNVSAIMATLAAFGLAMYCGI 325
            ||:.|..::.||:....:..            |.:||||.|.|.|.:|:::|.|:..||.::.|:
Worm   301 YFNVTIAVLVLFTAFYSVKWYFRMDHSWPLHIDWLRSKPMLALGGVLSSVLAILSGIGLLLWFGM 365

  Fly   326 EFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMP------VAERMGLMMSEAAVSITITSVTD 384
            .|..|.|.||||::.||:||.|:.:|.|..|:.|.|      :.:||...|||:||:|.|||.||
Worm   366 FFAEITLIAPFLVLSIGVDDMFIAVAAWHNTEMKYPGRSPKVMKKRMIEAMSESAVAIFITSFTD 430

  Fly   385 FISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGC------- 442
            .:||..|.|:...:|:.||..:...:.||||:.||||||.|.||...:....:|...|
Worm   431 VLSFGAGTITDIIAVQGFCAMTAACMFFTFLYQITFFAALMVISAKAQMSGRNSCMPCITAGDIY 495

  Fly   443 -----RVQPMSVAIKEKRNFLYKAIMA-------------------------GGIDAN-DPDN-- 474
                 .:||   .:|:|::...|...|                         ...|:: ||..
Worm   496 TIEDGSLQP---NLKKKKSKSRKDAKAEKEKKDEAKNDKNMEIEENAENAEKSSYDSSPDPSQIH 557

  Fly   475 -PIDNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVGACYGITQIKEGLERRKLSREDSYS 538
             |:.::..| ..||:|.....:.|...|..:.:.|..||..:.|||..:::||:..||.......
Worm   558 IPVKSRGAM-GHFFRDYYVPWLLNWKTKLFMFVTFIIYLGISVYGICVMEQGLDYDKLLLHSDPL 621

  Fly   539 VEFFDREDDYYREFPYRMQVIIAGPLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLS 603
            ||...||.:.:.... ::::.|....|.:....::::|.:....|:.||....:.|..|:|.:..
Worm   622 VEALKREIELFHGGD-QIEIAIQNCPNITIAESRDRIELVAQEFENISYSLGGKGTSFWMREYKK 685

  Fly   604 FLERNNELLNVTVDDEQTFIDAVKEHW--LFP-GNPFSLD-VRFNE---DETQIIASRFLIQAVN 661
            :.......||   |:.:::|..|.| |  ||. ...:|.| |..||   |..::.:.||.|....
Worm   686 YSNLTGSYLN---DNRESWIVGVYE-WSQLFAFYKLWSQDFVWANESDYDTLELKSYRFRIGVHR 746

  Fly   662 ITDTNHEKEMVRDLRQICKDSP-LNASIFHPYFVFFDQFELVRPVSLQAMVIGAIIMMIISFVFI 725
            ::.......:..:||.:....| ||...:.......||..::...::....:....|..::.:||
Worm   747 LSTPTDLVLITEELRGVADRHPDLNIVTYQQSRAIADQLNVILSSTITNDTLAMFCMFCVALIFI 811

  Fly   726 PNILCSLWVAFSVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKR-S 789
            ||.:|:|::.|::::|::||.|:::||.|.||.||||.:||.||||::|:|||.:.::|:... |
Worm   812 PNPICALFITFAMVTIDIGVIGFLSLWSVKLDPISMITIIMSIGFSIEFSAHITHGFVSNDSNLS 876

  Fly   790 PKARVREALHSLGLPIIQGSSSTILGIVALLLAQSYIFLVFFKMVFLVIFFGAMHGLFLLPVLLS 854
            ...|..:|:..|..|::.||.|||||:..|....||:.|||||.:.||:..||.|.|.|||:|||
Worm   877 AFDRCVDAMEKLAWPVVHGSLSTILGVFVLAFIDSYMVLVFFKTISLVLIIGAWHALMLLPILLS 941

  Fly   855 LFGP 858
            :..|
Worm   942 MCIP 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	242/906 (27%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	64/152 (42%)
ptr-6	NP_494986.2	Patched	52..945	CDD:308203	250/923 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1934
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	1	1.000	-	-		FOG0001635
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10796
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X653
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.880