DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and ptr-3

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_493718.2	Gene:	ptr-3 / 173426	WormBaseID:	WBGene00004218	Length:	927	Species:	Caenorhabditis elegans

Alignment Length:	931	Identity:	216/931 - (23%)
Similarity:	401/931 - (43%)	Gaps:	156/931 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTERAIVEQYFKVNYTHRFN 85
            ||..  |...||:.::|||:........:.|.|... |:|.....:.|   :|:|.|....|
Worm    31 ICYC--PWTCIILTIMLTLVLSLKIPFTRMQNDISD-FTPFGARSRVE---LEKYRKFFNNH--- 86

  Fly    86 VGRITRPGRFGR-----VIVITKDGDENMIRREVFQELRQLDNIIQNATTTYDGDTY-------- 137
                      |.     ..:.:|.|| ||:      .:.||::.: :...|...|.|
Worm    87 ----------GEPKAIYAFITSKVGD-NML------GISQLNDTV-HVLDTISRDFYLKTSQGPK 133

  Fly   138 TYKDNCARWENECFENDILN------LDALMDDIEAGQLNLTFPFMFNPVTWDAHLFPVFFGGTK 196
            .:::.|:.:   |..|:.:.      |.:.....:...|:|.:| :...:....::.|.|||...
Worm   134 NFEEYCSGF---CLLNEPVKHFYSGMLISGQHGTDFSHLDLGYP-ITTVLGTKLYMDPNFFGVKV 194

  Fly   197 LTEDNYV------------------------ISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVV 237
            .|.:|.|                        :|:..:|....:..:...:|.:..|.:     ::
Worm   195 TTSNNKVESIADGNTKLFGDHTKQEPNNIREVSLVVLQFRSELGDEVTPEDLRNYEHQ-----IL 254

  Fly   238 GNAENSGQFKHISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRS----- 297
            ....:..|.:||:|.......:..|:.:...|::|:....|.:|.:||.||.::......
Worm   255 DYIHDEYQSEHINVYILTDSYITEEIVRAGLTLLPFLVIGFTIMAVFSSITFVVSAYYTKQLNFY 319

  Fly   298 KPFLGLMGNVSAIMATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRR------- 355
            ||.|.:|..|...||..|:.|...:.|..|..|....|||::.||:||:::|...|:|
Worm   320 KPILAVMACVCPFMACGASLGAMFFIGFRFGSILCVTPFLVLAIGVDDSYLMANAWQRITCHRRK 384

  Fly   356 ----TKAKMPVAERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLW 416
                ....:.:..|:..|..|...|||||::|:.::|.||..:|...:::|...:..||...|::
Worm   385 HARFESVNVELKNRITEMFIETGPSITITTITNALAFGIGATTPAAEIQLFSIGNALAVITDFVF 449

  Fly   417 HITFFAACMAISG-YRERKNLHSIFGCRVQPMSVAIKEKRNFLYKAIMAGGIDANDPDNPIDNKD 480
            .|||:.|.||:.| |...:.|.:   .:..|.|.:..|..:       .|.:.:::.|   |.|.
Worm   450 TITFYGALMAVVGRYEIEQELKT---QKPLPESESPSETSS-------TGSMRSSELD---DCKF 501

  Fly   481 HMLMAFFKDKMAAVINNKWCKAIIILAFASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDRE 545
            ..::|    .:...:.|.|..::::...|.|......|...||..|...||...:|..||.|.:.
Worm   502 RRMIA----NVCKFLTNTWVCSVVLGLLAVYWYICIVGTVNIKSELSPNKLFLAESNIVEIFKQR 562

  Fly   546 DDYYREFPYRMQVIIAGPLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLERNNE 610
            ..:...:.....|::..|.:.::|..:.::|.|..:.|.......|..|:.|||.:..||:::.|
Worm   563 KSHIIPYYSACWVLVENPGDINNPNQRAKLEELIESFEALPSANGRYSTKFWLRDYEDFLKQSEE 627

  Fly   611 LLNVTVDDEQTFIDAVK-----EHWLFPGNPFSLD------------------VRFNEDETQIIA 652
             :::.:::|:....|::     ...:.|..||...                  ::.||...|:
Worm   628 -IDLPMEEEEDEELAIQFTVNGSQVVTPSQPFGQGNELRQFLEWPEFSFWKGFIQVNESTYQM-- 689

  Fly   653 SRFLIQAV----NITDTNHEKEMVRDLRQIC---KDSPLNASIFHPYFVFFDQFELVRPVSLQAM 710
            |:||:...    ::.|.::..:::.:.|.:.   |...||.:::.....|.|..|.:.||::|:.
Worm   690 SKFLVTTAYHGSDLVDWSNRAKLLNEWRSVADQDKFKSLNVTVYEEDAKFLDLIETMSPVAIQSA 754

  Fly   711 VIGAIIMMIISFVFI---PNILCSLWVA-FSVISIELGVAGYMALWDVNLDSISMINLIMCIGFS 771
            :.....|.:::.:||   |    :|:|| ||::|..|||.|.|:.|..:||.|.|...:|.||||
Worm   755 LWTFASMFLVAALFISHPP----TLFVATFSILSTSLGVFGIMSWWGADLDPIMMSATVMSIGFS 815

  Fly   772 VDFTAHICY-TYMSSKKRSP-KARVREALHSLGLPIIQGSSSTILGIVALLLAQSYIFLVFFKMV 834
            ||..:|:.| .|.::|..|. :.|::..:.::|.||.:.|.||.|.:::|......:..:|.|.:
Worm   816 VDIPSHVSYHFYQTAKDTSDIRRRLQMTIEAVGFPIFEASLSTSLCVMSLFFVDLNMAQIFAKCM 880

  Fly   835 FLVIFFGAMHGLFLLPVLLSL 855
            .||:..|.:||:.::||:.:|
Worm   881 LLVVVIGMVHGMLVMPVIFAL 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	202/887 (23%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	48/163 (29%)
ptr-3	NP_493718.2	Patched	48..904	CDD:308203	208/912 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1934
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10796
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880