Protein Alignment Ptr and ptr-10

DIOPT Version :10

• Sequence 1: NP_610209.2
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_001370752.1
• Gene: ptr-10 / 172229
• WormBaseID: WBGene00004224
• Length: 900
• Species: Caenorhabditis elegans
• Alignment Length: 904
• Identity: 277/904 - (30%)
• Similarity: 466/904 - (51%)
• Gaps: 66/904 - (7%)

  Fly     1 MTCGISCVDKTLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEG 65
            |..|..|::....|.|:..|:.::.:|..|::.|:|:|....||...|:...|..||::|.....
 Worm     1 MRLGFGCLEPKAAKFFHSYGLLVSGYPFIFLVSPILVTCFLATGLIGLEPLSDALYLYTPTDAPS 65

  Fly    66 KTERAIVEQYFK-VNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQ-NA 128
            ||||.|:...:. |:.|  |..||.....|..:|.|:.:.|. |::.|....||:.:::.|: |.
 Worm    66 KTERRIIHDAWPLVDGT--FVAGRAVTQSREVQVAVVARSGG-NILDRVFSNELKLMESFIRNNI 127

  Fly   129 TTTYDGDTYTYKDNC-ARWENECFENDILNLDALMDDIEAGQLNLTFPFMFNPVTWDAHLFPVFF 192
            |..:...|:::.|.| |..:..|..||.:.|.:.:.  :.| :|:|:|.:  .::..:.......
 Worm   128 TVQFSNRTWSFADLCLAGPDGRCANNDHIQLASRLH--QHG-INITYPTV--RLSDKSAYIASAL 187

  Fly   193 GGTKLTE----DNYVISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNAENSGQFKHISVSY 253
            ||.||.:    :|.::...|..|:|.:.............||..|...:.  |...|.|:||::|
 Worm   188 GGVKLAKGDNGENIIVEATAWLLIYQLKFYPNEISYVSGLWEREFKNKMD--EYKKQAKYISITY 250

  Fly   254 FASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMG-------DAVRSKPFLGLMGNVSAIM 311
            |.|:||..||.:|.:.:.|.|...|:::..||::..::.       |.|.:||.|.::|..:|.|
 Worm   251 FHSQTLSDELNRNAERLAPKFIGAFVILVCFSVLCSIVTIKGSGYIDWVVTKPILSVLGVSNAGM 315

  Fly   312 ATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAVS 376
            ...:|.|:..|..|::..|....|||::.:|.|:.|:|:|..:||...:...:|:...|::||||
 Worm   316 GIASAMGMLTYLEIQYNDIIAVMPFLVVAVGTDNMFLMVASLKRTDRNLKYDQRIAECMADAAVS 380

  Fly   377 ITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFG 441
            |.||::||.:||.:|.|:...:|:|||.|::.|:..||.:.:|||.|.:......|.:.||||:
 Worm   381 ILITALTDALSFGVGTITTIPAVQIFCIYTMCALLLTFAYQLTFFCAILVYYTRIEEQGLHSIW- 444

  Fly   442 CRVQPMSVAIKEKRNFLYKAIMAGGIDANDPDNPIDN---------------------KDHM--- 482
              ::| :|..........|....|    :.|..|:.:                     ..|:
 Worm   445 --LRP-AVTYSSTSPLNVKLFWLG----SQPQKPLPSCGTVSSTSSVSTMTSQATSPASKHLHHC 502

  Fly   483 -LMAFFKDKMAAVINNKWCKAIIILAFASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDRED 546
             ..:||::..|.|:...|.:||..|.:..||..:.||.|.:|||||...|..:|||:...:...:
 Worm   503 AATSFFRNWYAPVLMQPWIRAIAGLWYLIYLGISIYGCTHLKEGLEPANLLVDDSYATPHYRVLE 567

  Fly   547 DYYREFPYRMQVIIAGPLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLERNNEL 611
            .:|..:...:|::::.|.:..||:.:..::.:.||..:..........:.|||.    ::.:.|:
 Worm   568 KHYWHYGASLQIVVSNPPDLRDPVERINMDKMASTFANCKVAIGDDSVQFWLRE----MQVSEEI 628

  Fly   612 LNVTVDDEQTFIDAVKEHWLFPGNPFSLDV---RFNEDETQIIASRFLIQAVNITDTNHEKEMVR 673
            ..:..|:|:.:..|.:..:.....|:.:||   |.|..|..|...||:|...:|:.|..:.|...
 Worm   629 HKIQYDNEKFYDHAAQYIYSDMSQPWVVDVVWGRNNNSERIIKTFRFMIGMRDISTTTKQTEATN 693

  Fly   674 DLRQIC-KDSPLNASIFHPYFVFFDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFS 737
            ..|:|. :....|.:.:.|.::|.||:.||.|.::|.:::....|::||.:.||..:||.|||.:
 Worm   694 TFREIASRFEQYNVTTYMPLWLFTDQYALVVPNTMQDIIVAVACMLVISALLIPQPVCSFWVAVT 758

  Fly   738 VISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLG 802
            :.||:|||.|:|.||:||||:||||.:||.:|||||::|||.|.|:.||:.:..|||.:||..||
 Worm   759 IGSIDLGVLGFMTLWNVNLDAISMITIIMSVGFSVDYSAHITYAYVISKESTTSARVCDALGDLG 823

  Fly   803 LPIIQGSSSTILGIVALLLAQSYIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGPGSC 861
            .|:.||:.||||.:..|....:|:.:.|||.|||.|..|.:|||..||::||:| .|.|
 Worm   824 WPVAQGAMSTILAVSVLSDVPAYMIVTFFKTVFLAISIGFLHGLVFLPLMLSVF-VGCC 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_610209.2	Patched	53..845	CDD:308203	253/834 (30%)
ptr-10	NP_001370752.1	Patched	50..878	CDD:308203	261/850 (31%)