DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and ptr-2

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_491221.1	Gene:	ptr-2 / 171950	WormBaseID:	WBGene00004217	Length:	933	Species:	Caenorhabditis elegans

Alignment Length:	881	Identity:	273/881 - (30%)
Similarity:	459/881 - (52%)	Gaps:	48/881 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CVDKTLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTERAI 71
            ||::.....|..||..|..||..|.:.|:|.|.....|...|....|..|||:|:..:.|.||..
Worm     5 CVERRAASLFRQLGFLICDHPLPFFVFPLLFTAAMGVGLLHLNPLSDAVYLFTPLGAQSKMERMS 69

  Fly    72 VEQYFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQ-NATTTYDGD 135
            :.:.:.:. .:.:..||.....|..:|..:.:: |.|::..:....:.|||..|| .....::|.
Worm    70 IHEKWPLT-DNNYIPGRAVTQSREIQVTALARN-DSNILDPKFANAVYQLDKYIQTRVRVLHNGH 132

  Fly   136 TYTYKDNCARWEN-ECFENDILNLDALMDDIEAGQLNLTFP-FMFNPVTWDAHLFPVFFGGTKL- 197
            .|:||:.|.:::| .|..|..::   ::.|:.....|:|:| |.|..   :........||..:
Worm   133 YYSYKNLCLQYKNGGCPSNKHVH---ILSDLHNHGFNITYPYFRFGS---EGGYIGSSLGGVTVM 191

  Fly   198 ---TEDNYVISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNAENSGQFKHISVSYFASRTL 259
               .|.:.:.|..|..::|.:....:.......|||....|::......   .:||::||.|:||
Worm   192 KGENETDILASAKAWFMIYHLKFHPEEMSYISGEWELELGRMLTQYPED---PYISITYFHSQTL 253

  Fly   260 DHELEKNTKTVVPYFSSTFLLMGLFSIITCMMG--------DAVRSKPFLGLMGNVSAIMATLAA 316
            ..||::|..|::|.|..:..|:.:||.: |.:.        |.|.|||.|.::|.|||.:|.|..
Worm   254 ADELKRNADTLIPRFIISITLLIVFSTL-CSLSFIDGSFSIDWVLSKPILSILGVVSAGIAILTG 317

  Fly   317 FGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAVSITITS 381
            .|.....|:.:..|....|||::.:|:|:.|:|:|..|||.....|.||||..:::|||||.|||
Worm   318 VGFLSLMGMPYNDIVGVMPFLVLAVGVDNMFLMVAAVRRTSRTHTVHERMGECLADAAVSILITS 382

  Fly   382 VTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQP 446
            .||.:||.:|.|:...:|:|||.|:..|:.|.|::.|||||||:|::...|....:|:|  .::.
Worm   383 STDVLSFGVGAITTIPAVQIFCVYTGVAIFFAFIYQITFFAACLALAMKHEASGRNSLF--LIEA 445

  Fly   447 MSVAIKEKRNFLYKAIMAGGIDANDPDNPI--DNKDHMLMAFFKDKMAAVINNKWCKAIIILAFA 509
            :|...|...:...:....|.:    ||:..  |.|..:...||.:..|.|:.:...:.|.::.|.
Worm   446 VSAEKKTSLSTFQRLFNLGSV----PDHSASHDVKQPLTSRFFGEWYAPVLMHPVVRGIAMVWFV 506

  Fly   510 SYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLNYSDPLVQEQ 574
            .||:||.||.::||||||...|..||||::..:...:.|:.::..::|::|....:..:...:::
Worm   507 IYLLGASYGCSRIKEGLEPVNLLVEDSYAIPHYRLLEKYFWKYGQQVQIVINNAPDLRNHTSRDR 571

  Fly   575 VENLTSTLEHTSYVTSRRYTESWLRSFLSFLERNNELLNVTVDDEQTFIDAVKEHWLF--PGNPF 637
            |..:......:.:.......:.||.....:.::.   |.|.:.|...:  .:..|:|.  ..||.
Worm   572 VHAMVLDFATSKHAIGMESVQFWLFEMERYYQKE---LEVQIIDSSFY--GLLHHFLASKTNNPL 631

  Fly   638 SLDVRF-----NEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQICKDSP-LNASIFHPYFVFF 696
            :.|:.:     :::.|.:.:.||::...::..|..:.:.....|::....| .|.:.|.|.::|.
Worm   632 AEDIYWGPMPDDDNGTMVKSFRFILGMKDLVTTMDQTDATMSFREVAARWPEFNVTTFMPIWMFT 696

  Fly   697 DQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDSISM 761
            ||:.::.|.::|.::|..::|::|:.:|||..:||||||.:..||:.||.|||.||.||||:|||
Worm   697 DQYIIIIPNTVQNIIIALLVMIVIAVLFIPQPMCSLWVALACASIDFGVIGYMTLWGVNLDAISM 761

  Fly   762 INLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAQSYI 826
            |.:||.||||||::|||.|.|:.|::.:...||:|||.:||.|:.||:.|||:.:..|....:|:
Worm   762 ITIIMSIGFSVDYSAHIAYGYVVSREDTAAGRVKEALSALGWPLSQGAMSTIIAVSVLADIPAYM 826

  Fly   827 FLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGPGSCL 862
            .:.|||.|.|.|..|.:|||..||||||:|..|.|:
Worm   827 IVTFFKTVVLSISLGLLHGLVFLPVLLSIFVRGCCI 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	247/816 (30%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	63/146 (43%)
ptr-2	NP_491221.1	Patched	47..858	CDD:308203	257/833 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	394	1.000	Domainoid score	I387
eggNOG	1	0.900	-	-		E1_KOG1934
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1007
Isobase	1	0.950	-	0	Normalized mean entropy	S5641
OMA	1	1.010	-	-		QHG28777
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	1	1.000	-	-		FOG0001635
OrthoInspector	1	1.000	-	-		otm14195
orthoMCL	1	0.900	-	-		OOG6_102973
Panther	1	1.100	-	-	O	PTHR10796
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3619
SonicParanoid	1	1.000	-	-		X653
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.820