Protein Alignment Ptr and ptr-11

DIOPT Version :9

• Sequence 1: NP_001246145.1
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_490687.1
• Gene: ptr-11 / 171609
• WormBaseID: WBGene00004225
• Length: 820
• Species: Caenorhabditis elegans
• Alignment Length: 867
• Identity: 201/867 - (23%)
• Similarity: 373/867 - (43%)
• Gaps: 116/867 - (13%)

  Fly    23 IAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTERAIVEQYFKVN-YTHRFNV 86
            :|.:|.|.|::.:|..|:..:|...::.:.|....|||...:...|..:..:|:.:: |..|
 Worm    14 LAAYPVYSILLSILSILVLSSGLVHIRLEPDIRKAFSPDDSDAGYETRVWLEYYGLDIYPER--- 75

  Fly    87 GRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQNATTTYDGDTYTYKDNCARWENECF 151
                     ...|...|..:.::::.....::..:||.:..|....|||.   :.||
 Worm    76 ---------AFCIFTAKRENSSILQEGALADIYTVDNRLSAAVGYQDGDG---RKNC-------- 120

  Fly   152 ENDILNLDALMDDIEAGQLNLTFPFMFNPVTWDAHLFPVF------------FGGTKLTEDNYV- 203
                   |.|.|      ||..|..:.|....:.....||            |.|..|:..::.
 Worm   121 -------DPLCD------LNSPFHLLANLTRRNNGTTSVFTYPDMPYSGLDIFLGLHLSNADFEP 172

  Fly   204 ----ISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNAENSGQFKHISVSYFASRTLDHELE 264
                ||..::.|.||..:||  .:.|.| :::....:...::||..|:|:..:.|:.:..:.|:.
 Worm   173 PTERISSKSLVLWYFSRSDT--PEGKLA-FKDAIDELFQLSKNSSAFEHVQFTIFSDQVANREMI 234

  Fly   265 KNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIMATLAAFGLAMYCGIEFIG 329
            :.........:..|.|:....||..:...:|:...:|.....::.:.||:|:||...:.|.....
 Worm   235 RGAIEATTLMTIGFFLLLTQVIIVIVRLSSVKMAFYLVATSLLTPMAATVASFGAICWMGFPSFS 299

  Fly   330 INLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAVSITITSVTDFISFLIGIIS 394
            |....|||::|||:||.|::|..|:...|......|:..::.:...||||||:|:.|:|.||.::
 Worm   300 IQCVTPFLVLGIGVDDAFILLHRWKHHIAITDTPRRLEQVIVDVGPSITITSLTNIIAFGIGFLT 364

  Fly   395 PFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQPMSVAIKEKRNFLY 459
            |...:.:||..:..|:...:::..|..|..              :|.|....            |
 Worm   365 PTPQMSLFCLTASLALLLDYIFTYTILAPI--------------VFLCNDPD------------Y 403

  Fly   460 KAIMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVGACYGITQIKE 524
            |:|      ||:.:..|...|..|..:    .:.|.:.|...|.|::....|.: ..||:..:|.
 Worm   404 KSI------ANETEPKISRADTWLSKY----SSFVCSVKGRVACIMVLLGMYAL-TTYGVVTMKT 457

  Fly   525 GLERRKLSREDSYSVEFFDR-EDDYYREFPYRMQVIIAGPLNYSDPLVQEQVENLTSTLEHTSYV 588
            ..|..|....:|..|:.... :..:.|.||  :.||:..|.|.......:...|:...|||...:
 Worm   458 TFEPAKAFPSNSKLVDSLSNIKPVFNRYFP--ITVIVNNPPNIEIKAEYDSFNNMMDRLEHVPGI 520

  Fly   589 TSRRYTESWLRSFLSFLERNNELLNVTV--------DDEQTFIDAVKEHWLFPGNPFSLDVRFNE 645
            .....:..:|..:::| ::...:|:..|        |:..|::||:       |||..:.....:
 Worm   521 RGDNRSLIFLPQYVNF-DKTMNILSTLVGEKYRPSYDNLPTWMDAI-------GNPPLVKYHMGD 577

  Fly   646 D-ETQIIASRFLIQAVNITDTNHEKEMVRDLRQIC-KDSPLNASIFHPYFVFFDQFELVRPVSLQ 708
            | :|.:.|.|..:....:::.......::.:|.|. ::|..||::|............|....:.
 Worm   578 DNKTIVTAFRLTLLGKGMSEWAERARAMQHIRTILHEESQFNATLFDCDSAILSIILTVGTDLIG 642

  Fly   709 AMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVD 773
            ::.:..:.|.|:.||||.|......:...:.||...:.|.::||..:||.:..:::::..|||||
 Worm   643 SIAVTVVCMAIVCFVFIANFNAVAVITSVIASICYVLVGGLSLWGADLDPVIQVDVLLATGFSVD 707

  Fly   774 FTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAQSYIFLVFFKMVFLVI 838
            :|||:.|.:..: :.:|:.||..:|..:.:|:.:...||.|.::.|:...:|..:.|.|.||||:
 Worm   708 YTAHVAYNFFRA-RGTPQERVYSSLAEMAMPMCEAGLSTFLCMLPLIFVPTYAIVCFAKTVFLVV 771

  Fly   839 FFGAMHGLFLLPVLLSLFGPGS 860
            ..|.:||||:|||:|:||...|
 Worm   772 AIGLLHGLFILPVILALFSKDS 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	183/820 (22%)
		Sterol-sensing	295..442	CDD:289145	40/146 (27%)
ptr-11	NP_490687.1	Patched	35..791	CDD:355433	194/842 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1934
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10796
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880