DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and disp3

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_021334179.1	Gene:	disp3 / 100535855	ZFINID:	ZDB-GENE-081104-407	Length:	1319	Species:	Danio rerio

Alignment Length:	963	Identity:	166/963 - (17%)
Similarity:	277/963 - (28%)	Gaps:	390/963 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 ISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFS--IITCMMGDAVRSKPFLGLMGNVSAIM 311
            :.|.|..:...|.|:.|.       |:|. :|:.|||  .||.::........||...|..|..:
Zfish   393 VKVLYGGTELFDDEVRKT-------FNSD-MLLALFSGGCITVLVYVLTSFSVFLTFFGLASIGL 449

  Fly   312 ATLAAFGLAMY---CGIEFIGI-NLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSE 372
            :.|.|  |.:|   .|::::|| |..|.|::||||:||.||.::.:|::.......:||...|..
Zfish   450 SCLVA--LFLYHVVFGVKYLGILNGVAAFVIIGIGVDDVFVFISTFRQSVHLTCPMQRMISTMKT 512

  Fly   373 AAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAI--SGYRERKN 435
            |..:..:||.|...::.....|...:|..|..:....|...:||......|.:.|  |....|.|
Zfish   513 AGRATFLTSFTTAAAYAANTFSQIPAVHDFGLFMSLIVSCCWLWVSVLMPAALCIWSSCGAARAN 577

  Fly   436 -----------LHSIFGCRVQPMS----VAIKEKRNFLYKAIMAGGIDANDPD------------ 473
                       |.|..|    |:|    ||       |....|..|:..::||
Zfish   578 SCPRWWTTLTKLSSSPG----PLSDDDDVA-------LITVEMEPGVYDSEPDAALLSLSTEAPL 631

  Fly   474 ------------------------NPIDNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVG 514
                                    .|:..|...::..:   ...::.:.||  ..:|..||:...
Zfish   632 SASTEGNVGVVSAHIQRLLRCWVAEPVVEKRKTIIGVY---AVVLLGSVWC--CCLLRPASHAPV 691

  Fly   515 ACYGITQIKEGLERRKLSREDSYSVE-----FFDREDDYYREFPYRMQVIIAG-----PLNYSDP 569
            ..:..|.::..|:.|........|..     |.:|..:.:....:....  :|     |.|.|.|
Zfish   692 LFHRDTNLQRLLDMRSNLSAQGISCHMCSGVFMERPHNLHSTADFTSST--SGNHPTIPSNQSKP 754

  Fly   570 LVQEQVENLTS--------TLEHTSYVTSRRYTES------W---------LRSFLSFLERNNEL 611
            ......:.|..        .||..|.|...||:.|      |         :.||.::...::..
Zfish   755 ASNSSAQTLAGGLLTVYVFKLEMGSAVPLYRYSLSASVPAPWQASSAAHGDVPSFQAYSSPHSNF 819

  Fly   612 LNVTVDDEQTFIDAVKEHWLFPGNPFSLDVRFNEDETQIIAS-RFLIQAVNITDTNHEKEMVRDL 675
                    .|.|.....|...|...:.|.:|..:...:.||. .|.:.:|       |::..|.|
Zfish   820 --------STRISVCVSHAYHPRPRWMLTLRSCDGSRRWIAEFEFYVASV-------EQQRSRKL 869

  Fly   676 -----------RQICK-----------DSPLNASIFHP--------------------------- 691
                       .::|:           |.|...|.:.|
Zfish   870 YFAQHTISPYPSRVCEGPPGCVFSSGPDGPTQGSFYAPLPAAPAQVKISRTSGFNPCSGGKCGKP 934

  Fly   692 ------------YFVF---------------------------FDQF-----------------E 700
                        :.||                           ||.|                 .
Zfish   935 AVRPLVDTGAMVFVVFGILGVNRTQRLDNHVIGDLGNVIYDQDFDVFNEIGHLCKLCKVISANTN 999

  Fly   701 LVRPVSLQAMVIGAIIMMIISFVF-------IPNIL----------------------------- 729
            ||:|...|.:..|..:..|:..:.       .||:|
Zfish  1000 LVKPGGAQCLPSGNSLTSILPLLHPECHSLPEPNLLPGQLSHGAVGLQGGRVHWISMAFESTTYK 1064

  Fly   730 -------------------------------------CSLW--VAFSVISIE------------- 742
                                                 |..|  :...:|.:|
Zfish  1065 GKSSFQTHADFLQWESFLQKQLASLPASSALRRGFQTCQHWKQIFMEIIGVESALYSLLLSLAIC 1129

  Fly   743 ------------------LGVAGYMAL---------WDVNLDSISMINLIMCIGFSVDFTAHICY 780
                              |.:.|.:.|         |:  :.::..|:|.:.:|.|||:..|:..
Zfish  1130 IASVAVFTAHPLLLLPILLSILGMVCLVVAVMYWLGWE--MGAVEAISLSILVGSSVDYCLHLVE 1192

  Fly   781 TYM-------SSKKRSPKARVR--EALHSLGLPIIQGSSSTILGIVALLLAQSYIFLVFFKMVFL 836
            .|:       |....|.|.::|  ||.:.:|:.|:..:.:|::..:.|.......|..|.::|.:
Zfish  1193 GYLLAGDTETSGLDPSIKRQIRTLEAANHVGVAIVSSAVTTVISTIPLFFCVIVPFAKFGQIVAI 1257

  Fly   837 VIFFGAMHGLFLLPVLLSLFGP-----------------------GSCLTWTG 866
            .........|.:...||:..||                       |..|.|||
Zfish  1258 NTAISIAFTLTVTTALLAAMGPSDFTRHPRAVLKAAAVVLIMGVSGGLLWWTG 1310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	156/917 (17%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	43/163 (26%)
disp3	XP_021334179.1	Patched	226..>602	CDD:330476	59/222 (27%)
disp3	XP_021334179.1	COG1033	<1157..>1274	CDD:331188	23/118 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589942
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930