Protein Alignment Ptr and ptchd4

DIOPT Version :9

• Sequence 1: NP_001246145.1
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: XP_031758858.1
• Gene: ptchd4 / 100497488
• XenbaseID: XB-GENE-6044462
• Length: 905
• Species: Xenopus tropicalis
• Alignment Length: 894
• Identity: 230/894 - (25%)
• Similarity: 425/894 - (47%)
• Gaps: 88/894 - (9%)

  Fly     8 VDKTLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQL---KYQIDPEYLFSPIAGEGKTER 69
            :.:.|..|.|.||:.:::||.:|:.:|.:||::  .|:..|   |.:.|.|.|.:|.....|.||
 Frog    23 IHRGLKSSSYKLGLFVSRHPVFFLTLPAVLTII--FGFSFLSRYKTEKDLEALVAPSHSLAKIER 85

  Fly    70 AIVEQYFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQNATTTYDG 134
            ::....|.::.:.:.....:..|||:.|||.::|.|...:::.|   .:..:...:.:....:.|
 Frog    86 SLASSLFPLDQSKKQLYSDLHTPGRYARVIFLSKPGGNILLQAE---RILHIHRAVLDMKVHHRG 147

  Fly   135 DTYTYKDNCA-RWENE-CFENDILNLDALMDDI-EAGQLNLTFPFMFNPVTWDAHLFPVFFGGTK 196
            ..|::...|. |.|:: |..::|:   ::::|| :|...|.|          .|....|.:..||
 Frog   148 YNYSFPHLCVLRSEDKRCVLDEII---SVLEDIRQAALSNKT----------SASKVQVSYPTTK 199

  Fly   197 L--------------------TEDNYVISVPAIQLVYFV-TADTKRQDAKGAEWEETFLRVVGN- 239
            |                    ::|..|.|..|||:.|:: ...:..||....:||..|..::..
 Frog   200 LKDGRQSFIGHQLGGVAEVPNSKDQRVKSARAIQITYYLQNYGSTTQDHISEQWETEFCTLMHQL 264

  Fly   240 AENSGQFKHISVSYFA-----SRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKP 299
            .|.....:..|::.|:     .:|:|   ...:|.||     :.:|:.:.:.::..|.|.:||||
 Frog   265 QEERADIQLYSLTSFSLLRDFQKTID---LSRSKIVV-----SLMLVLMAATLSSSMKDCLRSKP 321

  Fly   300 FLGLMGNVSAIMATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAE 364
            ||||:|.::..::::.|.|:.......:....|..||..:|.|....|.:|:|||||:..:|..:
 Frog   322 FLGLLGVLTICISSVTAAGIFFVTDGRYNSTLLGIPFFAMGHGTKGVFELLSGWRRTRESLPFKD 386

  Fly   365 RMGLMMSEAAVSITITSVTDFISFLIGIISPF---RSVRIFCTYSVFAVCFTFLWHITFFAACMA 426
            |:....|:..||.|:||....|:|.:| .|||   .:|||||......:...:.:..:|:.:|:.
 Frog   387 RVADAYSDVMVSYTMTSSLYIITFGMG-ASPFTNIEAVRIFCQNMCITIVLNYFYVFSFYGSCLV 450

  Fly   427 ISGYRERKNLHSIFGCRVQPMSVAIKEKRNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKM 491
            .:|..|:...||||.|::.  |....:::...::.||:.|...:....|...::|.:..|.::..
 Frog   451 FAGQLEQNRYHSIFCCKIP--SEEYLDRKPIWFQTIMSDGHQHSSHHEPDPYENHFIQHFLREHY 513

  Fly   492 AAVINNKWCKAIIILAFASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRM 556
            ...|.|.:.|..:::.:..|...:..|..||..|.....|...||.||.:...:..|:..:...:
 Frog   514 NEWITNTYVKPFVVILYLIYASFSFMGCLQISGGSNIINLLASDSPSVSYAHIQQKYFSNYSPVI 578

  Fly   557 QVIIAGPLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLERNNELLNVTVDDEQT 621
            ...|..||.|.:..|||.::.::|...          ||||:..:..||    :..||:..::..
 Frog   579 GFYIYEPLEYWNATVQEDLKTISSGFN----------TESWIEQYYQFL----KAANVSASNKTE 629

  Fly   622 FIDAVKEHWLFPG--NPFSLDVRFNE--DETQIIASRFLIQAVNITDTNHE-KEMVRDLRQICKD 681
            ||..::..:|...  ..|..|:..:.  :|:.|||||..:.|....:|..| .|::..||.:...
 Frog   630 FIGVLQNSFLRRAEFQHFKNDIIISRSGEESNIIASRMFLVARTSENTQREVVELLEKLRPLSLI 694

  Fly   682 SPLNASIFHPYFVFFDQFELVRPVSLQAMVIG--AIIMMIISFVFIPNILCSLWVAFSVISIELG 744
            ..:...:|:|.|||.|.:.|.  |::..::.|  .::::|::|..:.:.|.:.|:..:|.|||||
 Frog   695 QSIKFIVFNPTFVFMDHYGLA--VTMPVLISGFSVLLVLILTFFLVIHPLGNFWLIITVTSIELG 757

  Fly   745 VAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGS 809
            |.|.|.||:|::|.:|::.||..:.|::|..:.:.||::.:.:.:....::::|...|..|||..
 Frog   758 VLGLMTLWNVDMDCVSIMCLIYALNFAIDHCSPLLYTFVLATEHTRTLCIQDSLKEHGTAIIQNV 822

  Fly   810 SSTILGIVALLLAQSYIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGP 858
            .|.::|:|.||...|.:....||.:.|......:|...:|||.|:.|.|
 Frog   823 VSFLVGLVPLLFVPSNLTSTLFKCLLLTGSCTLLHCFVILPVFLTFFPP 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	209/831 (25%)
		Sterol-sensing	295..442	CDD:289145	50/149 (34%)
ptchd4	XP_031758858.1	Patched	84..871	CDD:355433	210/829 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010