DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and ptchd3

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_031759849.1	Gene:	ptchd3 / 100494800	XenbaseID:	XB-GENE-950407	Length:	982	Species:	Xenopus tropicalis

Alignment Length:	1023	Identity:	308/1023 - (30%)
Similarity:	521/1023 - (50%)	Gaps:	165/1023 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CGISCVDKTLNKSFYHLGICIAKHPGYFIIIPVLLTL-----LCMTGYQQLKYQIDPEYLFSPIA 62
            |...|::|.|::.|..||..||::|.:||::||:|::     .|....:|: ...:.|:   |..
Frog     6 CNTDCLEKPLSRGFGSLGRLIARYPWWFIVVPVVLSIGSGVGFCFLEQRQI-MMFENEF---PSP 66

  Fly    63 GE-GKTERAIVEQYFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQ 126
            |. .|.|...:..:|.:|.|...:..::...|.|..:|:::.  .:|::.:..::||::||..::
Frog    67 GSLLKREGDFIRTHFPMNNTEHLSTRQLYNEGSFASIIIVSL--SQNLLNKSKYEELQRLDAAVR 129

  Fly   127 NATTTYDGDTYTYKDNCARWE-NECFENDILNLDALMDDIEAGQL--NLTFPFMFNPVTWDAHLF 188
            :.:.   |....::..||... :.||     :.:.|:|.|:.|.:  |:|:|...|.|     ..
Frog   130 SLSL---GSEIHFQSLCALINGSTCF-----SANPLLDLIQNGTIRTNITYPMFQNRV-----FL 181

  Fly   189 PVFFGGTKLTEDNYVISVPAIQLVYFVTADTKRQDAKGAEWEET--------------------- 232
            ..:.||..|..||.|:...|::.||::..||::|.....:|...
Frog   182 GKYIGGVTLGPDNTVLRAQALRFVYYLREDTEQQLVNNTKWLNNFIASFPQHLQMLQLKSVQVKK 246

  Fly   233 -------------------------------------------FLRVVGNAENSGQFKHISVSYF 254
                                                       |||..|..|.  .:..|.|.|:
Frog   247 SCFFLVQFPPQCLSPVSPALIEHFLQKLVGPHADIFCKKFFVFFLRWAGLQEQ--YYLFIFVYYY 309

  Fly   255 ASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIMATLAAFGL 319
            .|.:|..:||::.|..:|:||.||::..|||:::|:....||:|.::.|.|.:|..:|.|.:|||
Frog   310 TSVSLQKQLEEDAKRAMPFFSVTFIVTILFSVLSCVRCHNVRNKIWVALFGVISPGLAILTSFGL 374

  Fly   320 AMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAVSITITSVTD 384
            .:.||..|....:.||||::|.|:|:.|::::.|::||.:..:.|||.....|||||||||::||
Frog   375 LLMCGAPFAITAVNAPFLILGAGVDNMFIIISCWQQTKMRATLEERMAETYQEAAVSITITTLTD 439

  Fly   385 FISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQPMSV 449
            .::|.|||::.|.||:.||.|:..|:.|.:::.||||.|.:|::|..|..|.|.....:|....
Frog   440 VLAFYIGIMTHFPSVQSFCIYAGTALVFCYVYCITFFGAVLALNGKLENDNRHWFICVKVNDTE- 503

  Fly   450 AIKEKRNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVG 514
              :..:|.:|:....||.........|   :|.:..||.......:.|:|.|.:.::.:..||..
Frog   504 --ESGQNTMYQMCCLGGSFETSEGIEI---EHPVTVFFHKYYGVFLTNQWTKLLTVVVYLGYLAI 563

  Fly   515 ACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLNYSDPLVQEQVENLT 579
            :.||..:::.|::.:|...::||..:::..|..|:..:..|:.|::...:.|.:|...:::|:..
Frog   564 SIYGCFKLQGGVDIQKFPNDNSYLSQYYTNEALYFAGYGPRVMVVVTSEIAYWEPQTSKEIESCM 628

  Fly   580 STLEHTSYVTSRRYTESWLRSFLSFLERNNELLNVTVDDEQTFIDAVKEHWLFPGNPFSLDVRF- 643
            ..||:.||| .:::||||||::    |..::.|||::..:..|::             :||:.|
Frog   629 QKLENNSYV-DKKFTESWLRTY----EHMSKALNVSIITKDGFMN-------------NLDIIFA 675

  Fly   644 ---------NEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQICKDSPLNASIFHPYFVFFDQF 699
                     :::..:|.||||.:|.:|:.....|:.|...||.|.....:...::||.|:..|::
Frog   676 YFAEFKQDIDKEGNKIKASRFFVQTINVVGAIDERNMATQLRGIAASCNIPLFVYHPIFICLDRY 740

  Fly   700 ELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDSISMINL 764
            .|:...::|.|::..::|:::|.:||||.||||||.|::.||.:||||:||.|.|||||||:|.|
Frog   741 ALIIQSAVQNMIVAFVVMLVVSLLFIPNPLCSLWVTFAIASIIVGVAGFMAFWRVNLDSISLITL 805

  Fly   765 IMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAQSYIFLV 829
            ::||||||||::||.|...||||...:.||.:|||.||.||:||:.|||||:|||.:|:||||..
Frog   806 VICIGFSVDFSSHIAYACFSSKKEKTEERVIDALHVLGYPIVQGALSTILGVVALSVAESYIFKT 870

  Fly   830 FFKMVFLVIFFGAMHGLFLLPVLLSLFGPGSCLTWTG-------KDDGSDAEVDDGLDDRQLEK- 886
            |||:..|||.||.:|||..:||.|::.   :|..|:.       |.....|.:...| :||.|.
Frog   871 FFKLTCLVIAFGVLHGLVFIPVFLTII---ACPRWSHVSKVKPLKISHQPANIMTEL-ERQRENP 931

  Fly   887 ------------------------PFSQSYYMQYPSIGINGPYGSKGF 910
                                    ||:..|||.:.: |:...:.|:.|
Frog   932 IRSVQKDNLSGYSCSMPDVLSTSIPFTTCYYMGWKA-GVFSIFHSEKF 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	269/869 (31%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	61/146 (42%)
ptchd3	XP_031759849.1	Patched	95..898	CDD:355433	267/846 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	487	1.000	Domainoid score	I385
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H111041
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1257
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	1	1.000	-	-		FOG0001635
OrthoInspector	1	1.000	-	-		oto102690
Panther	1	1.100	-	-	LDO	PTHR10796
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X653
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.070