Protein Alignment Ptr and ptch2

DIOPT Version :9

• Sequence 1: NP_001246145.1
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: XP_002937129.2
• Gene: ptch2 / 100492958
• XenbaseID: XB-GENE-1033868
• Length: 1423
• Species: Xenopus tropicalis
• Alignment Length: 1317
• Identity: 267/1317 - (20%)
• Similarity: 458/1317 - (34%)
• Gaps: 383/1317 - (29%)

  Fly    60 PIAGEGKTERAIVEQYFKVNYT--------HRFNVGRITRPGRFGRVIVITKDGD---ENMIRRE 113
            ||...|..||.|.:.:..|..|        .:...|....|||          .|   .|:...:
 Frog   191 PIIENGMIERMIEKLFPCVIITPLDCFWEGSQLQGGSAYLPGR----------ADIQWTNLDPIQ 245

  Fly   114 VFQELRQ---LDNIIQNATTTYDGDTYTYKDNCARWENECFEND-----ILNLDALMDDIEAGQL 170
            :.:||.|   ||...:.......|..|..:......:::|.|:.     ..|.| ::..:..|..
 Frog   246 LMEELGQFTSLDGFKEMLDKAEVGQAYMERPCLDPTDSDCPESSPNKKTKKNPD-IVSTLRRGCY 309

  Fly   171 NLTFPFMFNPVTWDAHLFPVFFGGTKLTEDNYVISVPAIQLVYFVTA---------------DTK 220
            ..:..||:    |...|   ..||.....|..:.|..|:|.:|.:.:               |..
 Frog   310 GFSKKFMY----WQKEL---ILGGMLKGPDGELKSAEALQTMYLLMSPGQLYEHFKDDYEIHDIN 367

  Fly   221 RQDAKGA----EWEETFLRVVGNA--ENSGQFKHISVSYFASRTLDHELEKNTKTVVPYFSSTFL 279
            ..:.|.|    .|:..|:.....:  :||.|..|.    |::.||:..::..:.......:..:|
 Frog   368 WNEEKAAAILESWQRKFVEQAQQSIPQNSSQDIHA----FSTTTLNDIMKSFSDVSAIRVAGGYL 428

  Fly   280 LMGLFSIITCMMGDAVRSKPFLGLMGNVSAIMATLAAFGLAMYCGIEFIGINLAA----PFLMIG 340
            ||..::.:|.:..|..:|:..:||.|.:...::..:..||....||.|   |.|.    |||.:|
 Frog   429 LMLAYACVTMLRWDCSKSQGAVGLAGVLLVALSVASGLGLCSLLGISF---NAATTQVLPFLALG 490

  Fly   341 IGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTY 405
            ||:||.|::...:..|....|..||.|..:.....|:.:||:.:.|:|.:..:.|..::|.|...
 Frog   491 IGVDDMFLLAHAFTETSLSTPFKERTGECLRRTGTSVALTSINNMIAFFMAALVPIPALRAFSLQ 555

  Fly   406 SVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQPMS---VAIKEKR------NFLYKA 461
            :...|.|.|...:..|.|.:::..:|.......|..|...|.|   :.|:.:.      |..|..
 Frog   556 AAVVVVFNFAMVLLIFPAILSLDLHRREDQRLDILCCFYSPCSSRVIQIQPQEFSDANDNHTYHP 620

  Fly   462 IMAGG-------------------------------------------IDANDP----------- 472
            ...|.                                           :...||
 Frog   621 SSYGNPTITTSTQITTTVQAFTQCDPSGHHIVTILPPTSQISTSPSVIVPTMDPLGSQVFSPSSS 685

  Fly   473 --------DNPIDNKDHMLMAFFK--------DKMAAVINNKWCKAIIILAFASYLVGACYGITQ 521
                    |...:.::.:.:.|.|        :|.|.|:.....|.|::..|.:.|....||.|.
 Frog   686 TRDLLAQLDESKEKRECVPLPFLKWSLSDFAREKYAPVLLKAETKGIVVALFMALLGLGLYGTTM 750

  Fly   522 IKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLNYSDPLVQEQVENLTSTLEHTS 586
            :.:||....:...::....|...:..|: .| |.|.::.....:|  |..||.:.:|........
 Frog   751 VHDGLYLTDIVPRETKEYNFISAQFKYF-SF-YNMFIVTKDGFDY--PKAQESLYDLHEAFGSVK 811

  Fly   587 YVTSR----------RYTESWLRSFLSFLERNNELLNVTVD------------------------ 617
            ||...          .|.:.|||...:..:::.||.::|.|
 Frog   812 YVVREEGRDLPKMWLHYFQDWLRGLQTAFDKDWELGHITEDSYRNGTEDSVLAFKLLIQTGNKKE 876

  Fly   618 ----DEQTFIDAVKEHWLFPGNPF--SLDVRFNEDETQIIAS----------------------- 653
                ::.|....|.|..|.|.:.|  .|.|..:.|.....||
 Frog   877 PFNFNQLTSRRLVDEKGLIPQDAFYIYLTVWVSNDPLGYAASQANFYPQPPEWIHDRYDTTGENL 941

  Fly   654 -----------RFLIQAVNITDTNHEKEMVRDLRQICKDSPLNASIFHPY---FVFFDQFELVRP 704
                       :|......:..|:...|.:..:|.:|::........:|.   |:|::|:
 Frog   942 RIPAAEPIEFAQFPFYLNGLRQTSDFIEAIESVRSVCEEFVKQGVQSYPSGYPFLFWEQY----- 1001

  Fly   705 VSLQAMVIGAI-IMMIISFVFIPNILCSLWVA------FSVISIELGVAGYMALWDVNLDSISMI 762
            :.|:...:.|| |::..:|:....:|.:.|.|      .:::::||  .|.|.|..:.|.:|.::
 Frog  1002 IGLRHWFLLAISIVLACTFLVCAILLLNPWTAGIIVFILAMMTVEL--FGIMGLIGIKLSAIPVV 1064

  Fly   763 NLIMCIGFSVDFTAHICYTYMSS-KKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAQS-- 824
            .||..:|..|:||.|:...:::: ..|:.::.:  ||..:..|::.|:.||:||:  |:||.|
 Frog  1065 ILIASVGIGVEFTVHVALGFLTAIGDRNQRSVL--ALEHMFAPVLDGAISTLLGV--LMLAGSEF 1125

  Fly   825 -YIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGPGSCLT------------------------- 863
             :|...||.::.::...|.::||.||||||||.||.:.:|
 Frog  1126 DFILRYFFAVLTILTILGLLNGLVLLPVLLSLIGPPAEVTPADNSSRLPTPTPEPLPPPLNHHAF 1190

  Fly   864 ------WTGKDDG----SDAEVDDGL--DDRQLEKPFSQSYYM----------------QYPSIG 900
                  ::..:|.    |:.....||  ||.||   :.:|.|:                .||.|.
 Frog  1191 YMNHKGFSDPEDSSEYYSETTTTSGLEEDDPQL---YERSAYIIPPKPPHIILEASKDPTYPKIM 1252

  Fly   901 INGPYGSKGFLGAPYKAYGVDEKDLGLGTS--GEDSSESSSSRSQHRQQAAAT---EEEVVVRES 960
            :..|  .||....|.|.   |.||:....:  |:|.|..:....:..|:...:   :.::.....
 Frog  1253 LVKP--CKGNQDVPGKK---DSKDINNSEALPGKDISHRTCQEQKDTQEPRGSRMRQHQLATSSG 1312

  Fly   961 PTRRYDDGWRRSSYQNIYGQGAAQFQAQ---PDLYGKQVSATEWRQRLDT--------------- 1007
            ||       |.:..||...|.:.:.|..   |..|..::||........|
 Frog  1313 PT-------RTNQPQNSRAQHSTRPQGHRTAPPAYCAKMSAPNGSITTVTATASVTVAVHPSLPG 1370

  Fly  1008 ------HEQQQRQRQRRSPFENYRQDVEIDMQKAR------RNSHGDVIDLHGTPNSSVEERFRR 1060
                  ||          .||    |.:||....|      |..|.:|.:|...      |:.||
 Frog  1371 TVRGYNHE----------GFE----DSDIDCMAVRPEWAKKRVKHPEVFELEDL------EQDRR 1415

  Fly  1061 RGEPFSAESGDDSSYRH 1077
            :         |.||.||
 Frog  1416 Q---------DKSSVRH 1423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	197/995 (20%)
		Sterol-sensing	295..442	CDD:289145	40/150 (27%)
ptch2	XP_002937129.2	Patched	26..1172	CDD:355433	210/1020 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910