Protein Alignment Ptr and npc1l1

DIOPT Version :10

• Sequence 1: NP_610209.2
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: XP_002932620.2
• Gene: npc1l1 / 100487339
• XenbaseID: XB-GENE-964011
• Length: 1316
• Species: Xenopus tropicalis
• Alignment Length: 1002
• Identity: 214/1002 - (21%)
• Similarity: 401/1002 - (40%)
• Gaps: 221/1002 - (22%)

  Fly     9 DKTLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTER---- 69
            :|.|::||...|..:|.:|...|.:.:::.::...|...::...||..|:|.:..:.:.|:
 Frog   341 NKALSRSFRWWGTLVASYPKTVIGVSLIVVIILSAGIILIRLTTDPVELWSAVNSQARQEKDFHD 405

  Fly    70 AIVEQYFKVNYTHRFNVGRITRPGR---FGRVIVITKDGDENMIRREVFQELRQLDNIIQNATTT 131
            |....:|:.|........|::.|..   ||::      ....::..:...|:..|...:||....
 Frog   406 ANFGPFFRTNQLIITAKNRVSYPYDSLFFGKL------NFSGILSPDTIMEMLDLQEKVQNIVVW 464

  Fly   132 YD--GDTYTYKDNCARWEN-------EC--------FENDILNLDALMDDIEAGQLN-------- 171
            .:  ....|.||.|....|       :|        |:||....|..:....:||..
 Frog   465 SEKHQKNVTLKDICYAPLNPSNPTPTDCCVNSLMQYFQNDRAKFDLEVTQTMSGQTGTVGWRDHF 529

  Fly   172 ---LTFPFMFNPVT---------WDAHLFP-VFFGGTK-------------LTEDNYVISVPAIQ 210
               :..|..|..:|         :.|.:|| :..||.|             .:.:||..:.|...
 Frog   530 MYCVNSPLSFKDITDLELSCMADYGAPVFPFLAVGGYKDGQFSEAEALILTFSLNNYPRTDPRFD 594

  Fly   211 LVYFVTADTKRQDAKGAEWEETFLRVVGNAENSGQFKHISVSYFASRTLDHELEKNTKTVVPYFS 275
            .|..              ||:.:|.::...:.:.: .:::..|.|.|:|:.|:.:.|...:|.|:
 Frog   595 FVLL--------------WEKRYLEIIKEYKENPK-SNLTFGYMAERSLEDEINRTTTEDIPIFT 644

  Fly   276 STFLLMGLFSIITCMMGD-------AVRSKPFLGLMGNVSAIMATLAAFGLAMYCGI-EFIGINL 332
            .::|:  :|..|...:|:       .|.||..|||.|.:..:.|.|::.|...|.|| ..:.|..
 Frog   645 ISYLV--IFIYIALALGEYSSCRRVLVDSKVTLGLGGILVVLGAVLSSIGFYSYIGIPSTLIIVE 707

  Fly   333 AAPFLMIGIGIDDTFVML---------AGWRRTKAKMPVAERMGLMMSEAAVSITITSVTDFISF 388
            ..|||::.:|.|:.|:.:         .|.||       .|::|.::...|.|:.:.||::.:.|
 Frog   708 VVPFLVLAVGADNIFIFVLELQRDDRRPGERR-------EEQIGRVLGNVAPSMLLCSVSESLCF 765

  Fly   389 LIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQPMSVAIKE 453
            .:|.::...:||.|...:..|:...|:..|:.|.|.:::...|:..:.:.|..|        ||.
 Frog   766 FLGALTKMPAVRTFALNAALAILLDFVLQISMFVALVSLDSKRQEASRYDICCC--------IKT 822

  Fly   454 KRNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVGACYG 518
            |                 .:.|......:|:.|.|...:.::.|...:.|:::.|........|.
 Frog   823 K-----------------TEKPKKKSKGLLVPFMKKVYSPILLNPVSRFIVMVVFIFMFCAGLYF 870

  Fly   519 ITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLNYSD--------PLVQEQV 575
            :...:.||.:......|||.:::||..:.|. |.......:.....|:|.        ..|....
 Frog   871 MMHTRVGLNQELSVPLDSYVLDYFDYLNRYL-EVGVPTYFVTTTGYNFSSLDGINGICSSVGCDG 934

  Fly   576 ENLTSTLEHTSYVTSRRY----TESWLRSFLSFLERNNE----LLNVT----------------- 615
            ::||..:::.:....|.|    ..||:..|:.:|...::    |||.|
 Frog   935 DSLTQKIQYATEYPDRSYLAIPASSWVDDFIDWLNPTSDCCRLLLNGTFCSSTSALPGCLRKCMP 999

  Fly   616 ---------VDDEQTFIDAVKEHWLFPG--------NPFSLDVRFNEDETQIIASRFLI------ 657
                     ::...|::......  :|.        ..:...|:|| |:.:|.|:||:.
 Frog  1000 STTGALRPNLEQFNTYLPVFLND--YPNLKCPKGGLGAYDNSVKFN-DQGEIAATRFMAFHTPLK 1061

  Fly   658 --------------QAVNITDTNHEKEMVRDLRQICKDSPLNASIFHPY---FVFFDQFELVRPV 705
                          .|.|||::         ||::....| |..:| ||   :||::|:..:...
 Frog  1062 NSQEYTAALKTARELAANITES---------LRKVPGTDP-NFRVF-PYTITYVFYEQYMTIVQE 1115

  Fly   706 SLQAMVIGAIIMMIISFVFIPNILCSLWV-AFSVISIELGVAGYMALWDVNLDSISMINLIMCIG 769
            .|..:.:..|....:..:.:...|.|.:: ..::|.|.:...|.|.||.::.::||:|||:..:|
 Frog  1116 GLFTLALCLIPTFAVCCILLGMDLRSGFINLITIIMILIDTMGVMTLWGIDYNAISLINLVTAVG 1180

  Fly   770 FSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTIL-GIVALLLAQSYIF-LVFFK 832
            .||:|.:|:..::..|.|.:...|.:||..::|..:..|.:.|.| ||:.|..|::.:. :.||:
 Frog  1181 ISVEFVSHLTRSFAISSKPNKVERAKEATINMGSAVFAGVAMTNLPGIIVLAFAKAQLIQIFFFR 1245

  Fly   833 MVFLVIFFGAMHGLFLLPVLLSLFGPG 859
            :...:...|.:|||..|||:||.||||
 Frog  1246 LNLTITLLGLVHGLIFLPVVLSYFGPG 1272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_610209.2	Patched	53..845	CDD:308203	193/942 (20%)
npc1l1	XP_002932620.2	2A060601	31..1270	CDD:273337	210/998 (21%)