DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptr and ptchd3a

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_003201375.2	Gene:	ptchd3a / 100334931	ZFINID:	ZDB-GENE-111215-6	Length:	980	Species:	Danio rerio

Alignment Length:	898	Identity:	305/898 - (33%)
Similarity:	498/898 - (55%)	Gaps:	60/898 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CVDKTLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQL--KYQIDPEYLFSPIAGEGKTER 69
            ||:|.::..|...|..:..:|.:|.|.|:|::.:..||:..|  :...|.|..|:|:.|..|.||
Zfish    13 CVEKPISICFQKFGRFVGTYPWWFFISPLLISAVLGTGFCLLEDREANDIEDQFTPVNGPAKQER 77

  Fly    70 AIVEQYFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQNATTTYDG 134
            ..|:|.|..| ...|:..|:...|.:...|.:||  ..|::....|:|:..||..::....:...
Zfish    78 RFVQQNFPQN-DSLFSNQRLYTDGVYASFIAVTK--SSNILTDAAFREIVILDRKVKELNVSTGH 139

  Fly   135 DTYTYKDNCARWENECFENDILNLDALM-DDIEAGQLNLTFPFMFNPVTWDAHLFPVFF-----G 193
            :..|::..|||...:|..|.||::.... :::||.:|:..| |.|.        |...|     |
Zfish   140 EVLTFEGLCARRYKKCIPNKILDIHKYYGENLEATELSFPF-FRFG--------FSYIFLGYSVG 195

  Fly   194 GTKLTEDNYVISVPAIQLVYFVTADTK-RQDAKGAEWEETFLRVVGNAENSGQFKHISVSYFASR 257
            |..| ..:.:.|..:::|.||:..|.: |.|.    |...||:|.   .::.....|.|::..|.
Zfish   196 GVNL-NSSIIKSAKSVRLFYFLKEDNRTRTDL----WLNEFLKVF---PSNLSLNSIKVTHSTSL 252

  Fly   258 TLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIMATLAAFGLAMY 322
            :...|.|.|||.|:|.||.|:::...|||::|:..|.||:|.::...|..||.:|.|::||:.::
Zfish   253 SRQVEFEANTKDVIPLFSITYVIAIAFSILSCLRFDCVRNKVWVATFGVFSAGLAVLSSFGMMLH 317

  Fly   323 CGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAVSITITSVTDFIS 387
            .|:.|:.....:|||::|||:||.|::::.|::|.....|..|:.....|||:|||||::||.::
Zfish   318 IGVPFVMTVANSPFLILGIGVDDMFILISCWQQTNVHDRVETRLSNTYKEAAISITITTLTDVLA 382

  Fly   388 FLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQPMSVAIK 452
            |.||:::||||||.||.|:..::.|.:::.||||.|.:.::|.||..|.|.: .|:..|...|:.
Zfish   383 FYIGLMTPFRSVRSFCLYTSTSILFCYIYSITFFGAFLVLNGRRENSNKHWL-TCKEVPEECAVG 446

  Fly   453 EKRNFLYKAIMAGG-IDANDPDNPIDNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVGAC 516
            :.:  .|:....|| .|.:.....:...:|    |||......:...|.|..:|:.:..||:.:.
Zfish   447 QSK--WYELCCIGGAYDRHTGSEEVQPMNH----FFKKYYGPFLTKSWTKVFVIVFYCIYLIVSI 505

  Fly   517 YGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLNYSDPLVQEQVENLTST 581
            ||..||:||::.|.|:.:|||.|:::|.|..|:.|:...:.|:|.....|.|......:|.....
Zfish   506 YGCFQIQEGIDLRNLAADDSYVVKYYDNEKAYFSEYGPNIMVVIRQEFPYWDEKYMSDLETCIED 570

  Fly   582 LEHTSYVTSRRYTESWLRSFLSFLERNNELLNVTVDDEQTFIDAVKEH---WLFPGNPFSLDVRF 643
            .::.|::....:| ||::|:..:  ..:..||::.:      |..||:   :|...:.|..||.|
Zfish   571 FKNLSFIEKDIFT-SWIKSYKYY--GYHTKLNLSAE------DVFKENLGTFLRFYSDFKQDVNF 626

  Fly   644 NEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQICKDSPLNASIFHPYFVFFDQFELVRPVSLQ 708
            ..:  .|.||||.||.|||:....|..|:..||...:..|:...::||.|::.||:.::...::|
Zfish   627 TNN--SIHASRFFIQTVNISTALDEMNMLNKLRDTAQKCPVPLLVYHPAFIYHDQYAVIVTNTIQ 689

  Fly   709 AMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVD 773
            .:.:...:|::||.:.|||.||||||.||:.|:.:||.|:|||||||||:||||.|::|||||||
Zfish   690 NIAVTTAVMLLISLLLIPNPLCSLWVTFSIASVIVGVTGFMALWDVNLDTISMIILVVCIGFSVD 754

  Fly   774 FTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAQSYIFLVFFKMVFLVI 838
            |:|||.|.::|:||.|...:..|||.:||.||:||:.|||||:|.|..:::|||..|||::||||
Zfish   755 FSAHISYAFVSNKKPSANEKAVEALFNLGYPILQGAVSTILGVVVLSASKNYIFRTFFKIMFLVI 819

  Fly   839 FFGAMHGLFLLPVLLSLFGPGSCLTWTGKDDGSDAEVDDGLDDRQLEKPFSQS 891
            |||..|||..:||.|:.|  ..|       :|:.||...|.:::.::|.::.:
Zfish   820 FFGLFHGLTFIPVFLTFF--DMC-------NGTPAENKSGPEEQAMKKSYTNN 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	279/802 (35%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	58/146 (40%)
ptchd3a	XP_003201375.2	Patched	60..838	CDD:280598	286/817 (35%)
ptchd3a	XP_003201375.2	MMPL	289..432	CDD:304422	57/142 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	492	1.000	Domainoid score	I358
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1255
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	1	1.000	-	-		FOG0001635
OrthoInspector	1	1.000	-	-		otm26181
orthoMCL	1	0.900	-	-		OOG6_102973
Panther	1	1.100	-	-	LDO	PTHR10796
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3619
SonicParanoid	1	1.000	-	-		X653
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.000