DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptr and LOC100331480

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_002667290.4	Gene:	LOC100331480 / 100331480	-ID:	-	Length:	835	Species:	Danio rerio

Alignment Length:	866	Identity:	285/866 - (32%)
Similarity:	464/866 - (53%)	Gaps:	51/866 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TCGISCVDKTLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGY---QQLKYQIDPEYLFSPIAG 63
            :|...|::|.:.:.|..||..:..||.:|:::|::::.....|:   .:||.. |....|:|..|
Zfish     3 SCTTDCIEKPIRRCFESLGKFVGLHPWWFVVLPLVMSAGLGGGFFFLNELKSD-DIVEQFTPKKG 66

  Fly    64 EGKTERAIVEQYFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQNA 128
            ..|.||...::.|..: ..:|:|.||...|.|..:|.   ....|::......|:.::|..|:..
Zfish    67 RAKMERRFFQETFPQS-DSQFSVIRINTDGVFASLIF---SSQSNILSVTALDEIIRIDVKIKRF 127

  Fly   129 TTTYDGDTYTYKDNCARWENECFENDILNLDALMDDIEAGQLNLTFP----FMFNPVTWDAHLFP 189
            :.:.|.:|:.:.|.||.....|..|.||::.. .:......:|:|:|    ..||.|    ||..
Zfish   128 SVSLDTNTFAFSDICADVNGTCNSNVILDVFG-YNASNVSFVNMTYPKYCRSEFNCV----HLGN 187

  Fly   190 VFFGGTKLTEDNYVISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNAENSGQFKHISVSYF 254
            | ....::.:|.:|.|..|::|.|::   .:..|.....|.:..:.|:.|...|    ...||||
Zfish   188 V-ISEVEVDQDGFVQSAKAVRLFYYL---QENNDTLTDAWLQKLMDVLSNVTTS----QTEVSYF 244

  Fly   255 ASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIMATLAAFGL 319
            .|.:...|.||:|::|...|:.|:.|...|||::|:..|.||:|.:|..:|..|...|.|::|||
Zfish   245 TSMSRQQEFEKSTRSVTQLFAVTYFLAISFSIMSCLRFDNVRNKAWLASLGVFSTAQAVLSSFGL 309

  Fly   320 AMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAVSITITSVTD 384
            .:...:.|:....::|||::||||||.|:|::.|:||..:..|.:||.....|||:|||||::||
Zfish   310 LLLLNVPFVITAASSPFLILGIGIDDMFIMISSWQRTNIQDSVPKRMSDTYREAAISITITTLTD 374

  Fly   385 FISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQPMSV 449
            .::|.:...:||.||:.||.|:..||...:.::||||.||:|::|.||..|.|.: .|...|..:
Zfish   375 VLAFYLSFSNPFGSVQSFCLYAGTAVLLCYFYNITFFGACLALNGRREGANKHWL-TCMKVPEEM 438

  Fly   450 AIKEKRNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVG 514
            ...|.:  .|.....||   :...|....::|.:..||:......:...||||.::|.:.:|:..
Zfish   439 PPGESK--AYTLCCVGG---SYNRNTGTEEEHPMALFFRKCYGPFLTTSWCKAFVVLIYFTYIGV 498

  Fly   515 ACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLNYSDPLVQEQVENLT 579
            :.||..|:|||::.:.|:.:|||.::::|.|..|:..:...:.:.|.|...|.:...:.|:|...
Zfish   499 SVYGCLQLKEGIDLKNLALDDSYIIQYYDAESAYFHYYGPNVMLAINGTFPYWEESERNQLETCI 563

  Fly   580 STLEHTSYVTSRRYTESWLRSFLSFLERNNELLNVTVDDE-QTFIDAVKEHWLFPGNPFSLDVRF 643
            .......:|.|   :.|||.:|    ||.....|::.:.. :|.:....||     ||. |....
Zfish   564 KRFLELDFVNS---STSWLHAF----ERYGVGRNISSEASFKTHLHEFLEH-----NPM-LKQDV 615

  Fly   644 NEDETQIIASRFLIQAV--NITDTNHEKEMVRDLRQICKDSPLNASIFHPYFVFFDQFELVRPVS 706
            |..:..|.|||..:|.:  |.|    ||.:|..||:..:..|....::||.|::.||:.::..|:
Zfish   616 NITDNNITASRLFLQTIVQNAT----EKTVVNSLRKTAEICPYQLLVYHPAFIYHDQYTVIGQVT 676

  Fly   707 LQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDSISMINLIMCIGFS 771
            ||.:.:...:|:.|:.:.||:.||:|||||::.|:.|||.|:|||.::.|||||||||::.||||
Zfish   677 LQTIAVSTAVMLFIALMLIPHPLCALWVAFAIASVILGVTGFMALLNIRLDSISMINLVISIGFS 741

  Fly   772 VDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAQSYIFLVFFKMVFL 836
            |||:|||.||::||.|.....|:.|||..||.||:||:.||::|:|.|..:.||||...|.:|.|
Zfish   742 VDFSAHISYTFVSSTKSDVNGRIVEALAHLGYPILQGALSTVVGVVVLSASSSYIFRTLFTIVLL 806

  Fly   837 VIFFGAMHGLFLLPVLLSLFG 857
            ||..|.:||:..:||.|:..|
Zfish   807 VITLGLLHGIAFIPVFLTFCG 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	266/798 (33%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	61/146 (42%)
LOC100331480	XP_002667290.4	Patched	54..827	CDD:280598	271/813 (33%)
LOC100331480	XP_002667290.4	MMPL	285..427	CDD:304422	60/141 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010