Protein Alignment Cyp6w1 and ERG11

DIOPT Version :10

• Sequence 1: NP_610206.1
• Gene: Cyp6w1 / 35543
• FlyBaseID: FBgn0033065
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: NP_011871.1
• Gene: ERG11 / 856398
• SGDID: S000001049
• Length: 530
• Species: Saccharomyces cerevisiae
• Alignment Length: 560
• Identity: 125/560 - (22%)
• Similarity: 214/560 - (38%)
• Gaps: 137/560 - (24%)

  Fly     9 SLTIVF-----YIWQ--------RRTLSF----WERHGVKY-IRPFPVVGCTREFLTAKVPFFEQ 55
            ||.|:.     .:||        |..|.|    |....|.| ::|:              .|||:
Yeast    32 SLIIIIPFIYNIVWQLLYSLRKDRPPLVFYWIPWVGSAVVYGMKPY--------------EFFEE 82

  Fly    56 IQKFHEAPGFENEPFVGVYMTHRPALVIRDLELIKTVMI--KKFQYFNNRVLQTDPHNDALGYKN 118
            .||.:      .:.|..|.           |..:.||.:  |..::..|..| .|...:| .|.:
Yeast    83 CQKKY------GDIFSFVL-----------LGRVMTVYLGPKGHEFVFNAKL-ADVSAEA-AYAH 128

  Fly   119 L---FFARS-----PGWRELRTK--ISPVFTSGKIKQMYPLMV-KIGKNLQDSA-----ERLGSG 167
            |   .|.:.     |..|.:..|  :....|....|...||:. ::.|..:||.     ||....
Yeast   129 LTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGT 193

  Fly   168 TEVQVKDLCSRFTTDLIATIAFGVEANALQDAKSEFFYHNRAIFSLTLSRGIDFAIIFMIPALAS 232
            .:|.|..  ...|....:....|.|..|..|....:.|.:       |.:|.. .|.|:.|.|.
Yeast   194 IDVMVTQ--PEMTIFTASRSLLGKEMRAKLDTDFAYLYSD-------LDKGFT-PINFVFPNLP- 247

  Fly   233 LARVKLFSR--ETTKFIRSSVNYVLKERERTGE-KRNDLIDILLALKREAAANPGKMSKEVDLDY 294
               ::.:.:  ...|.|..:...::|||.:..: :..||||.|  :|.....:..||:.:...:.
Yeast   248 ---LEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSL--MKNSTYKDGVKMTDQEIANL 307

  Fly   295 LVAQAAVFQTAGFETSASTMTMTLYELAKNEALQDRLRQE---IVDFFGDEDHISYERIQEMPYL 356
            |:.    ....|..|||:|....|..||:...:|..|.:|   ::|  |.:..::|:.:||||.|
Yeast   308 LIG----VLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLD--GGKKELTYDLLQEMPLL 366

  Fly   357 SQVVNETLRKYPIVGYIERECSQPAEGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEK 421
            :|.:.||||.:..:..:.|:..:...      .|..:..:|.|..:.:|....|...:|:|:..:
Yeast   367 NQTIKETLRMHHPLHSLFRKVMKDMH------VPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQ 425

  Fly   422 YDPERFNSSNRDNLNM----------------DAYMPFGVGPRNCIG-----MRLGLLQSKLGLV 465
            ::..|:|..:..:.::                ..|:|||.|...|||     .:||:|.|
Yeast   426 FNIHRWNKDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMS----- 485

  Fly   466 HILRNHRFHTCD-KTIKKIEWA-----PTSP--VMASKRD 497
            ..:|..::|..: ||:...::.     ||.|  ::..||:
Yeast   486 IFIRTLKWHYPEGKTVPPPDFTSMVTLPTGPAKIIWEKRN 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_610206.1	CYP6-like	67..498	CDD:410679	108/484 (22%)
ERG11	NP_011871.1	CYP51-like	83..521	CDD:410668	108/489 (22%)