DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6w1 and tbxas1

DIOPT Version :9

Sequence 1:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_991172.2	Gene:	tbxas1 / 792041	ZFINID:	ZDB-GENE-030131-8805	Length:	546	Species:	Danio rerio

Alignment Length:	557	Identity:	148/557 - (26%)
Similarity:	263/557 - (47%)	Gaps:	86/557 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SLTIVFYIWQRRTLSFW---------ERHGVKYIRPFPVVGCTREFLTAKVPFFEQ----IQKFH 60
            |||:..::.. .:|.:|         ||.|:|:.:|.|.:|....|...   ||:.    |.|:.
Zfish    19 SLTVCLFLLS-LSLLYWYSISPFSNLERCGIKHPKPLPFIGNLMMFRNG---FFKSQADLINKYG 79

  Fly    61 EAPGFENEPFVGVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQ---TDPHNDALGYKNLFFA 122
            ...|:        |:..|..::|.|.::::.||:|:|..|.||:..   |.|.:|     :|...
Zfish    80 RICGY--------YIGRRSTVIIADPDMLRQVMVKEFNKFPNRMTARGITKPMSD-----SLIML 131

  Fly   123 RSPGWRELRTKISPVFTSGKIKQMYPLM----VKIGKNLQDSAERLGSGTEVQVKDLCSRFTTDL 183
            :...|:.:|:.::|.|::.|:|:|.||:    ..:.:||:..||   |.....:......||.|:
Zfish   132 KGEQWKRVRSILTPTFSAAKMKEMVPLINTATETLLRNLKSHAE---SENSFNIHKCFGCFTMDV 193

  Fly   184 IATIAFGVEANALQDAKSEFFYHNRAIFSLTLSRGI---DFAIIFMIPALASLARVKLFSR-ETT 244
            ||::|||.:.::..:....|.:.....|:.:..|.|   ..|..|::..||.|...|  || |..
Zfish   194 IASVAFGTQVDSQNNPDDPFVHQASKFFAFSFFRPIMIFFMAFPFLLRLLAGLLPNK--SRDEMN 256

  Fly   245 KFIRSSVNYVLKERERTG--EKRNDLIDILLALK-------------------------REAAAN 282
            .|....:..::|:|:...  ::|.|.:.::|.::                         ..:.||
Zfish   257 SFFTQCIQKMIKQRDDLSPEQRRKDFLQLMLDVRTNKKFLSVEHFDVVNDADEEAYDGHENSPAN 321

  Fly   283 PG-KMSKEVDL---DYLVAQAAVFQTAGFETSASTMTMTLYELAKNEALQDRLRQEIVDFFGDED 343
            .. |.|::..:   |.:|.|:.:|..||:|||::|:..|.|.||.:...|.:|::|:.:||...:
Zfish   322 ESTKRSQQKRMMTEDEIVGQSFIFLVAGYETSSNTLAFTCYLLAVHPECQKKLQEEVDEFFSRHE 386

  Fly   344 HISYERIQEMPYLSQVVNETLRKYPIVGYIERECSQPAEGERFTLEPFHNMELPHGMSIYMSTVA 408
            .:.|..:||:.||..|:.|:||.||....:.|:..:..        ..:...||.|.|:.:.|..
Zfish   387 TVDYANVQELKYLDMVICESLRLYPPAFRVARDVEEDT--------VLNGQFLPKGASLEIPTGF 443

  Fly   409 VHRDPQYWPDPEKYDPERFNSSNRDNLNMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRF 473
            :|.||::|.:|.|:.||||....:...:...|:|||.|||:|:||||..|:.|:.||||.|....
Zfish   444 LHYDPEHWTEPTKFIPERFTPEAKARRHPFVYLPFGAGPRSCVGMRLAQLEIKVALVHIFRRFNV 508

  Fly   474 HTCDKTIKKIEWAPTSPVMASKRDIILRVEKVSGKKD 510
            ..|:.|...:| ..:...:..|..:::::.:....:|
Zfish   509 LACEDTEIPLE-LKSHTTLGPKNGVMVKITERENLED 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	138/512 (27%)
tbxas1	NP_991172.2	p450	51..536	CDD:278495	138/514 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8421
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.800