Protein Alignment Cyp6w1 and TBXAS1

DIOPT Version :9

• Sequence 1: NP_001286145.1
• Gene: Cyp6w1 / 35543
• FlyBaseID: FBgn0033065
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 151/594 - (25%)
• Similarity: 263/594 - (44%)
• Gaps: 124/594 - (20%)

  Fly     1 MLLLLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPFFEQIQKFHEAPGF 65
            |:.:.|..:|..:...:.....|..|:.|:::.:|.|.:|....|   :..|:|...:..:..|
Human    15 MVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF---RQGFWESQMELRKLYG- 75

  Fly    66 ENEPFVGVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQTDPHNDALGYK----NLFFARSPG 126
               |..|.|:..|..:||.:.::||.|:::.|..|.||:.      ..|.:|    ::.|.|...
Human    76 ---PLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMA------SGLEFKSVADSVLFLRDKR 131

  Fly   127 WRELRTKISPVFTSGKIKQ---------------------------------------------- 145
            |.|:|..:...|:..|:.:
Human   132 WEEVRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPFC 196

  Fly   146 MYPLMVK----IGKNLQDSAERLGSGTEVQVKDLCSRFTTDLIATIAFGVEANALQDAKSEFFYH 206
            |.||:.:    :..:|:..||   ||....::.....:|||::|::|||...::.|..:..|..|
Human   197 MVPLISQACDLLLAHLKRYAE---SGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKH 258

  Fly   207 NRAIFSLTLSRGIDFAIIFMIPALASLARVKLFSRET-------TKFIRSSVNYVLKERERTGEK 264
            .:..|...:.|.|...::.....:..|||: |.::..       .|.||:.:  .|::::...|:
Human   259 CKRFFEFCIPRPILVLLLSFPSIMVPLARI-LPNKNRDELNGFFNKLIRNVI--ALRDQQAAEER 320

  Fly   265 RNDLIDILLALKREAAA--------------------------NPGKMSKEVDLDYLVAQAAVFQ 303
            |.|.:.::|..:..|:.                          .|..|::.:.:|.:|.||.:|.
Human   321 RRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFL 385

  Fly   304 TAGFETSASTMTMTLYELAKNEALQDRLRQEIVDFFGDEDHISYE--RIQE-MPYLSQVVNETLR 365
            .||:|...:|::...|.||.|...|::|.:| ||.| .|.|::.|  .::| :|||..|:.||||
Human   386 IAGYEIITNTLSFATYLLATNPDCQEKLLRE-VDVF-KEKHMAPEFCSLEEGLPYLDMVIAETLR 448

  Fly   366 KYPIVGYIERECSQPAE--GERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFN 428
            .||......||.:|..|  |:|          :|.|..:.|:..|:|.||::||.||.::||||.
Human   449 MYPPAFRFTREAAQDCEVLGQR----------IPAGAVLEMAVGALHHDPEHWPSPETFNPERFT 503

  Fly   429 SSNRDNLNMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIEWAPTSPVMA 493
            :..|.......|:|||.|||:|:|:|||||:.||.|:|:|...||..|.:|...::....| .:.
Human   504 AEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKS-ALG 567

  Fly   494 SKRDIILRV 502
            .|..:.:::
Human   568 PKNGVYIKI 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	145/558 (26%)
TBXAS1	NP_001159725.2	p450	47..576	CDD:306555	145/560 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.850