DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6w1 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	519	Identity:	150/519 - (28%)
Similarity:	275/519 - (52%)	Gaps:	48/519 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPFFEQI-QKFHEAPGFENE 68
            :|:.:..::.||:...:...:::.|:....|.|.:|....:|.....|..:. :|:.|
Human    13 VLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECNEKYGE------- 70

  Fly    69 PFVGVYMTHRPALVIRDLELIKTVMIKK-FQYFNNRVLQTDPHNDALGY--KNLFFARSPGWREL 130
             ..|:|...:|.|||.|.::||||::|: :..|.|: :...|    :|:  ..|.||....|:.:
Human    71 -MWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQ-MPLGP----MGFLKSALSFAEDEEWKRI 129

  Fly   131 RTKISPVFTSGKIKQMYPLMVKIG----KNLQDSAERLGSGTEVQVKDLCSRFTTDLIATIAFGV 191
            ||.:||.|||.|.|:|.|::.:.|    ::|:..||   :...:.:||....:|.|:|....|||
Human   130 RTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAE---NSKSINLKDFFGAYTMDVITGTLFGV 191

  Fly   192 EANALQDAKSEFFYHNRAIFSLTLSRGID-FAII-----FMIPALASLARVKLFSRETTKFIRSS 250
            ..::|.:.:..|..:.:.:..|..   :| |.::     |:.|...:| .:.||.::.|.|:::|
Human   192 NLDSLNNPQDPFLKNMKKLLKLDF---LDPFLLLISLFPFLTPVFEAL-NIGLFPKDVTHFLKNS 252

  Fly   251 VNYVLKERERTGEKRNDLIDILLALKREAAANPGKMSKEV-DLDYLVAQAAVFQTAGFETSASTM 314
            :.. :|| .|..:|:...:|....:.....:...|..|.: ||: ||||:.:...|.::|:::|:
Human   253 IER-MKE-SRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLE-LVAQSIIIIFAAYDTTSTTL 314

  Fly   315 TMTLYELAKNEALQDRLRQEIVDFFGDEDHISYERIQEMPYLSQVVNETLRKYPIVGYIERECSQ 379
            ...:||||.:..:|.:|::||.....::..::|:.:.:|.||..|||||||.:|:|..:.|.|.:
Human   315 PFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKK 379

  Fly   380 PAEGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPE-RFNSSNRDNLNMDAYMPF 443
            ..|        .:.:.:|.|:::.:...|:|.||:||.:|||:.|| ||:..|:|::::..|:||
Human   380 DIE--------INGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPF 436

  Fly   444 GVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIEWAPTSPVMASKRDIILRVEKVSG 507
            |.|||||||||..|...||.::..|:|..|..|.:|...:: ....|::..::.|:|:|....|
Human   437 GAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLK-LDNLPILQPEKPIVLKVHLRDG 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	143/482 (30%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	144/486 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.720