Protein Alignment Cyp6w1 and CYP26B1

DIOPT Version :10

• Sequence 1: NP_610206.1
• Gene: Cyp6w1 / 35543
• FlyBaseID: FBgn0033065
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: NP_063938.1
• Gene: CYP26B1 / 56603
• HGNCID: 20581
• Length: 512
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 116/530 - (21%)
• Similarity: 201/530 - (37%)
• Gaps: 111/530 - (20%)

  Fly     3 LLLLLGSLTIVF----YIWQRRTLSFWERHGVKYIR--------PFPVVGCTREFLTAKVPFFEQ 55
            |...|.|:|::.    .:||.|    |.....|..:        .||::|.|..:|.
Human    15 LAACLVSVTLLLAVSQQLWQLR----WAATRDKSCKLPIPKGSMGFPLIGETGHWLL-------- 67

  Fly    56 IQKFHEAPGFEN---EPFVGVYMTH---RPALVIRDLELIKTVMIKKFQYFNNRVLQTD-PHND- 112
                 :..||::   |.:..|:.||   ||.:.:...|.::.:::.:     :.::.|: |.:.
Human    68 -----QGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGE-----HHLVSTEWPRSTR 122

  Fly   113 -ALGYKNLFFARSPGWRELRTKISPVFTSGKIKQMYPLMVKIGKNLQDSAERLGSGTE-VQVKDL 175
             .||...:..:.....|..|...|.:|:...::...|   ||...:||:.....|..| :.|...
Human   123 MLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLP---KIQLVIQDTLRAWSSHPEAINVYQE 184

  Fly   176 CSRFTTDLIATIAFGV-----EANALQDAKSEFFYHNRAIFSLTLS-------RGIDFAIIFMIP 228
            ..:.|..:...:..|.     :...|.:...:|..:   :|||.:.       |||.
Human   185 AQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDN---VFSLPVDLPFSGYRRGIQ-------- 238

  Fly   229 ALASLARVKLFSRETTKFIRSSVNYVLKERERTGEKRNDLIDILLALKREAAANPGKMSKEVDLD 293
                 || ::..:...|.||..:...      .|:...|.:|:|:...:|       ..||:.:.
Human   239 -----AR-QILQKGLEKAIREKLQCT------QGKDYLDALDLLIESSKE-------HGKEMTMQ 284

  Fly   294 YLVAQAAVFQTAGFETSASTMTMTLYELAKN----EALQDRLRQEIVDFFGD---EDHISYERIQ 351
            .|.........|.:.|:||..|..:.:|.|:    |.|:|.||...:...|.   |..:..:.:.
Human   285 ELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLS 349

  Fly   352 EMPYLSQVVNETLRKY-PIVGYIERECSQPAEGERFTLEPFH--NMELPHGMSIYMSTVAVHRDP 413
            .:.||..|:.|.:|.: ||.|           |.|..|:.|.  ..::|.|.|:..|....|...
Human   350 GLRYLDCVIKEVMRLFTPISG-----------GYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTA 403

  Fly   414 QYWPDPEKYDPERFNSS-NRDNLNMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCD 477
            ..:.|...:||:||:.: :.|......|:|||.|.|.|:|..|..|..|:..|.:....||....
Human   404 PVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELAT 468

  Fly   478 KTIKKIEWAP 487
            :|..:|...|
Human   469 RTFPRITLVP 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_610206.1	CYP6-like	67..498	CDD:410679	100/454 (22%)
CYP26B1	NP_063938.1	CYP26B1	60..490	CDD:410730	105/481 (22%)