DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6w1 and Cyp3a25

DIOPT Version :9

Sequence 1:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_062766.2	Gene:	Cyp3a25 / 56388	MGIID:	1930638	Length:	503	Species:	Mus musculus

Alignment Length:	513	Identity:	149/513 - (29%)
Similarity:	275/513 - (53%)	Gaps:	46/513 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPFFEQ-IQKFHEAPGFEN 67
            :||:.|| ::|||:...:...:::.|:...:|.|::|....:......|.|. .:|:.:..||..
Mouse    13 VLLVTSL-VLFYIYGTYSHGLFKKLGIPGPKPLPLLGTIFNYYDGMWKFDEDCYKKYGKIWGFYE 76

  Fly    68 EPFVGVYMTHRPALVIRDLELIKTVMIKK-FQYFNNRVLQTDPHNDALGY--KNLFFARSPGWRE 129
            .|        :|.|.|.|.|:||.|::|: :..|.||     .....:|:  |.:..:....|:.
Mouse    77 GP--------QPILAIMDPEIIKIVLVKECYSVFTNR-----RFFGPVGFMKKAITISEDEEWKR 128

  Fly   130 LRTKISPVFTSGKIKQMYPLMVKIG----KNLQDSAERLGSGTEVQVKDLCSRFTTDLIATIAFG 190
            |||.:||.|||||:|:|:|:|.:.|    :||:...|:   |..:.:||:...::.|:|...:||
Mouse   129 LRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEK---GEPISMKDIFGAYSMDVITGTSFG 190

  Fly   191 VEANALQDAKSEFFYHNRAIFSLTLSRGIDFAII---FMIPALASLARVKLFSRETTKFIRSSVN 252
            |..::|.:.:..|....:.|....:......:||   |:.| :..:....:|.|::..|.:..|.
Mouse   191 VNVDSLNNPQDPFVQKAKKILKFKIFDPFLLSIILFPFLTP-IYEMLNFSIFPRDSMNFFKKFVK 254

  Fly   253 YVLKERERTGEK-RNDLIDILLALKREAAANPGKMSKEV--DLDYLVAQAAVFQTAGFETSASTM 314
            .:.|||..:.:| |.|.:.:::..:.    :.|:.|::.  ||: :.|||.:|...|::.:::::
Mouse   255 RMKKERLASNQKNRVDFLQLMMNTQN----SKGQESQKALSDLE-MAAQAVIFIFGGYDATSTSI 314

  Fly   315 TMTLYELAKNEALQDRLRQEIVDFFGDEDHISYERIQEMPYLSQVVNETLRKYPIVGYIERECSQ 379
            ::.:||||.:..:|.:|:.||.....::..::|:.:.:|.||..||||:||.|||...:||...:
Mouse   315 SLIMYELATHPDVQKKLQDEIDRTLPNKAPVTYDALMDMEYLDMVVNESLRLYPIAIRLERVSKK 379

  Fly   380 PAEGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNLNMDAYMPFG 444
            ..|        .:.:.:|.|..:.:....:||:|:|||:|:::.||||:..|:.|::...|||||
Mouse   380 DVE--------INGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKENKGNIDPYIYMPFG 436

  Fly   445 VGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIEWAPTSPVMASKRDIILRV 502
            .|||||||||..|:..||.::.:|:|.....|::|...:: ....|:...::.|||:|
Mouse   437 NGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQIPLK-ISREPIFQPEKPIILKV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	139/480 (29%)
Cyp3a25	NP_062766.2	p450	39..493	CDD:278495	140/484 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720