DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6w1 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	510	Identity:	129/510 - (25%)
Similarity:	250/510 - (49%)	Gaps:	49/510 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPF-FEQIQKFHEAPGFE 66
            |::|:.:|..::.:|..|   |:.:.|:...||:|.||....:......| .|..:|:.:.
Zfish    13 LVVLVITLLFIYGVWPHR---FFIKLGIPGPRPWPFVGTLLSYAKGLCNFDMECAKKYGKV---- 70

  Fly    67 NEPFVGVYMTHRPALVIRDLELIKTVMIKK-FQYFNNRVLQT----DPHNDALGYKNLFFARSPG 126
                .|:|....|.|::.|||:||.|::|: :..|.||..:|    .|.:|     .:...:...
Zfish    71 ----WGIYDGRLPILMVADLEVIKVVLVKECYSNFINRRKRTTGLAGPFSD-----GIIMVKDER 126

  Fly   127 WRELRTKISPVFTSGKIKQMYPLMVKIGKNLQDSAERLGSGTEVQVKDLCSRFTTDLIATIAFGV 191
            |:.:|:.:||.||||::|:::|:.:........:.::......|::|::.:.::.|:|.:.:|.|
Zfish   127 WKRMRSTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKKDPEQPVKIKEVVAPYSLDVITSSSFSV 191

  Fly   192 EANALQDAKSEFFYHNRAIFSLTLSRGIDFAIIFMIPALASLAR---VKLFSRETTKFIRSSVNY 253
            :.:::.:.:..|..:.:......:...: ..:|.:.|:||...:   |.|||:....|..|.:..
Zfish   192 DIDSINNPEDPFVINVKKFIQFNMFNPL-LLLILLFPSLAIPLKKMGVTLFSKSAMDFFYSVLKK 255

  Fly   254 VLKERERTGEKRNDLIDILLALK--------REAAANPGKMSKEVDLDYLVAQAAVFQTAGFETS 310
            :..:..:..|.|.|.:.::|..:        .:.:..|.|...:.:   :::|:.||...|:||:
Zfish   256 IKDDHNKESEGRVDFLKLMLQNQIPDDQIQDSDTSEQPAKGLTDHE---ILSQSLVFILGGYETT 317

  Fly   311 ASTMTMTLYELAKNEALQDRLRQEIVDFFGDEDHISYERIQEMPYLSQVVNETLRKYPIVGYIER 375
            ::|:|..||.||.|....::|.:||...|..:..|:|:.:..|.||...:||::|..|....:||
Zfish   318 STTLTFLLYNLATNPDCLEKLVEEIDKNFPLDTPITYDALMRMDYLEMAINESMRLLPTAPRLER 382

  Fly   376 ECSQPAEGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNLNMDAY 440
            ...:..        ..:.:.:|.|..:.:.|..:..||..|..|.::.||||:..|:......|:
Zfish   383 SAKKTV--------VINGLTIPEGTLVGIPTYVLSHDPDIWESPGEFRPERFSPENKSEFLQYAF 439

  Fly   441 MPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIE----WAPTSPV 491
            :|||:|||||||||..::..||.:|.:|:|....||.:|...:|    :.|..|:
Zfish   440 IPFGLGPRNCIGMRYAVMIMKLFVVKLLQNFSVETCKETQIPLEMNVTFQPKVPI 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	122/479 (25%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	120/471 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8421
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.720