DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6w1 and Cyp6d5

DIOPT Version :9

Sequence 1:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	160/519 - (30%)
Similarity:	262/519 - (50%)	Gaps:	81/519 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPF--FEQIQKFHEAPGF 65
            :.||:.::|:: |::.:.|.|:|:|.|      ||..|       ..:||  .|.:.|...:.|.
  Fly     4 IYLLIAAVTLL-YVYLKWTFSYWDRKG------FPSTG-------VSIPFGALESVTKGKRSFGM 54

  Fly    66 --------ENEPFVGVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQTDPHNDALGYKNLFFA 122
                    ..||.:|:|:|.||||::||.:|...|::|.|..|::|.:..|..||.:. .:||..
  Fly    55 AIYDMYKSTKEPVIGLYLTLRPALLVRDAQLAHDVLVKDFASFHDRGVYVDEKNDPMS-ASLFQM 118

  Fly   123 RSPGWRELRTKISPVFTSGKIKQMYPLMVKIGKNLQDSAER---LGSGTEVQVKDLCSRFTTDLI 184
            ....||.||.|::|.|||||:|.|:.....:|..|.||..:   .....|:::|.|.:.:..|:|
  Fly   119 EGASWRALRNKLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDII 183

  Fly   185 ATIAFGVEANALQDAKSEFFYHNRAIFSLTLSRGIDFAII-----FMIPALASLARVKL-FSRET 243
            ||..||::.::..|..:||     .|.|..::|.....||     |:.|.|.... ||: :.:|.
  Fly   184 ATTIFGLDVDSFADPNNEF-----QIISKKVNRNNIEDIIRGTSSFLYPGLEKFF-VKIGWKQEA 242

  Fly   244 TKFIRSSVNYVLKERERTGEKRNDLIDILLALKREAAANPGKMS---------------KEVDLD 293
            |:.:|...|..:..||:....|.||:.:||.|:     |.||::               |.:..|
  Fly   243 TERMRELSNRTVDLREQNNIVRKDLLQLLLQLR-----NQGKINTDDNIWSAESTKNGVKSMSKD 302

  Fly   294 YLVAQAAVFQTAGFETSASTMTMTLYELAKNEALQDRLRQEI---VDFFGDEDHISYERIQEMPY 355
            .:..|..:|..||:||:|||.:.|||||.:|..:.::.::::   ::..|.:  ::|:.|.:|.|
  Fly   303 LIAGQLFLFYVAGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGK--LTYDAISDMKY 365

  Fly   356 LSQVVNETLRKYPIVGYIERECSQ--PAEGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPD 418
            |...:.||.||||.:..:.|.|::  |.        |...:.:..|..|.:|.:.:|||.:|:||
  Fly   366 LEACILETARKYPALPLLNRICTKDYPV--------PDSKLVIQKGTPIIISLIGMHRDEEYFPD 422

  Fly   419 PEKYDPERFNSSNRDNLNMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKK 482
            |..|.|||:..:.:| ....||:|||.|||.|||.|:|.:..|:.:..:|.|.     |..|:|
  Fly   423 PLAYKPERYLENGKD-YTQAAYLPFGEGPRMCIGARMGKVNVKIAIAKVLSNF-----DLEIRK 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	151/488 (31%)
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	140/439 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461024
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900