DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6w1 and Cyp6d2

DIOPT Version :9

Sequence 1:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	169/548 - (30%)
Similarity:	274/548 - (50%)	Gaps:	85/548 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLLLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPF--FEQIQKFHEAP 63
            :||.:|:..|   .|.:.:|..:.|:|.||             :...||:||  .:.:.|...:.
  Fly     4 ILLTILIAGL---LYRYVKRHYTHWQRLGV-------------DEEPAKIPFGVMDTVMKQERSL 52

  Fly    64 GF--------ENEPFVGVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQTDPHNDALGYKNLF 120
            |.        .....||:||.::.:::|||.:|.:.:|...|..|::|.:..|...|.|. .|||
  Fly    53 GMALADIYARHEGKIVGIYMLNKRSILIRDAQLARQIMTSDFASFHDRGVYVDEDKDPLS-ANLF 116

  Fly   121 FARSPGWRELRTKISPVFTSGKIKQMYPLMVKIGKNLQDSAE-RLGSGTEVQVKDLCSRFTTDLI 184
            ..|...||.||.|::|.|:|||||.|:..:..:|..|....| .|....||::||:.:.:..|:|
  Fly   117 NLRGASWRNLRQKLTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALDQSDEVEIKDVMTTYAVDII 181

  Fly   185 ATIAFGVEANALQDAKSEFFYHNRAIFSLTLSRGIDFAI------IFMIPALASLA-RVKLFSRE 242
            .::.||:|.::.::.|:||    |.|.|.| ||.....:      :|:.|.:|.|. |:...||.
  Fly   182 GSVIFGLEIDSFRNPKNEF----REISSST-SRDESLLLKIHNMSMFICPPIAKLMNRLGYESRI 241

  Fly   243 TTKFIRSSVNYVLKERERTGEKRNDLIDILLALKREAAANPGKMS----------------KEVD 291
            .|. :|..:...::.||.....|.|::.:|:.|:     |.||:.                |.:.
  Fly   242 LTS-LRDMMKRTIEFREEHNVVRKDMLQLLIRLR-----NTGKIGEDDDQVWDMETAQEQLKSMS 300

  Fly   292 LDYLVAQAAVFQTAGFETSASTMTMTLYELAK-NEALQDRLRQEIVDF------FGDEDHISYER 349
            ::.:.|||.:|..||.|::|:....|||||:. .|.|::  .||.||.      ...:|..:||.
  Fly   301 IEKIAAQAFLFYVAGSESTAAASAFTLYELSMYPELLKE--AQEEVDAVLMKHNLKPKDRFTYEA 363

  Fly   350 IQEMPYLSQVVNETLRKYPIVGYIERECSQ--PAEGERFTLEPFHNMELPHGMSIYMSTVAVHRD 412
            :|::.:|...:.||:||||.:.::.|||::  |..|.        |..:..|..|.:|...:.||
  Fly   364 VQDLKFLDICIMETIRKYPGLPFLNRECTEDYPVPGT--------NHIIAKGTPILISLFGMQRD 420

  Fly   413 PQYWPDPEKYDPERFNSSNRDNLNMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCD 477
            |.|:|:|..|||.||:|:|. |.:..||||||.|||:||.:|:|.:.||:.:..||.|  |....
  Fly   421 PVYFPNPNGYDPHRFDSNNM-NYDQAAYMPFGEGPRHCIALRMGKVNSKVAVAKILAN--FDLVQ 482

  Fly   478 KTIKKIEWA-PTSPVMASKRDIILRVEK 504
            ...|::|:. ..:||:.:|..:.||:.|
  Fly   483 SPRKEVEFRFDAAPVLVTKEPLKLRLTK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	156/510 (31%)
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	150/465 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461023
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900