DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6w1 and Cyp6g1

DIOPT Version :9

Sequence 1:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	226/509 - (44%)
Similarity:	349/509 - (68%)	Gaps:	13/509 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPFFEQIQKFHEAPGFEN 67
            :|.::.:..:..|.|.:|..|:|:|.|:.||.|.|::|.|:.....:..|...:.:.:..|..::
  Fly     6 VLFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMHLSEIYNDPRLKD 70

  Fly    68 EPFVGVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQTDPHNDALGYKNLFFARSPGWRELRT 132
            |..||:|..::|.|:|||:||||:::||.|..|:||..:.|||.|.|||.||||.|...|:.:||
  Fly    71 EAVVGIYSMNKPGLIIRDIELIKSILIKDFNRFHNRYARCDPHGDPLGYNNLFFVRDAHWKGIRT 135

  Fly   133 KISPVFTSGKIKQMYPLMVKIGKNLQDSAERLG---SGTEV-QVKDLCSRFTTDLIATIAFGVEA 193
            |::|||||||:||||.||.:|||:|:.:.:|.|   ||:.: ::|::|::|:||.|||||||:.|
  Fly   136 KLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFITEIKEICAQFSTDSIATIAFGIRA 200

  Fly   194 NALQDAKSEFFYHNRAIFSLTLSRGIDFAIIFMIPALASLARVKLFSRETTKFIRSSVNYVLKER 258
            |:|::..:||..:.|.:|:.|::|..||.:.|.:|.|.||.|::.|:.:.:.|:||::.:|::||
  Fly   201 NSLENPNAEFRNYGRKMFTFTVARAKDFFVAFFLPKLVSLMRIQFFTADFSHFMRSTIGHVMEER 265

  Fly   259 ERTGEKRNDLIDILLALKREAAANPGKMSKEVDLDYLVAQAAVFQTAGFETSASTMTMTLYELAK 323
            ||:|..||||||:|::|::||||.|.|.....:.|:|||||.||.|||||||:|||:..|||:||
  Fly   266 ERSGLLRNDLIDVLVSLRKEAAAEPSKPHYAKNQDFLVAQAGVFFTAGFETSSSTMSFALYEMAK 330

  Fly   324 NEALQDRLRQEI----VDFFGDEDHISYERIQEMPYLSQVVNETLRKYPIVGYIERECSQPAEGE 384
            :..:|.|||.||    |:..|.   :|||:||.:.||:.||:|.||.||::.:::|| .:..||:
  Fly   331 HPEMQKRLRDEINEALVEGGGS---LSYEKIQSLEYLAMVVDEVLRMYPVLPFLDRE-YESVEGQ 391

  Fly   385 -RFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNLNMDAYMPFGVGPR 448
             ..:|:||::..|.:|..:::...|:|.||:||.:|.::|||||:.:||.|:...||.|||.||.
  Fly   392 PDLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQFDPERFSPANRKNIVAMAYQPFGSGPH 456

  Fly   449 NCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIEWAPTSPVMASKRDIILRV 502
            ||||.|:||||||||||.:|:||....|:.|:|.:::.|...|:.:...|.|.:
  Fly   457 NCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFDPKGFVLQADGGIHLEI 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	215/475 (45%)
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	210/455 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450321
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	1	1.000	-	-		H59722
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	12	11.800