DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6w1 and Cyp6a2

DIOPT Version :9

Sequence 1:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	181/525 - (34%)
Similarity:	298/525 - (56%)	Gaps:	41/525 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLLLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVP---FFEQIQKFHEA 62
            :|:.||:...:::.|:: .|..::|.|.||.:..|.|:.|....|...:|.   |::...|:.::
  Fly     3 VLIYLLIAISSLLAYLY-HRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKS 66

  Fly    63 PGFENEPFVGVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQTDPHNDALGYKNLFFARSPGW 127
             ||   ||||.|..|:||..|.|.:|.|.::||.|..|.:|....:..:|.| .::||......|
  Fly    67 -GF---PFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDPL-TQHLFNLDGKKW 126

  Fly   128 RELRTKISPVFTSGKIKQMYPLMVKIG----KNLQDSAERLGSGTEVQVKDLCSRFTTDLIATIA 188
            :::|.:::|.|||||:|.|:|.::|:.    |.:.:......:|..:::|:|.:|||||:|.|.|
  Fly   127 KDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCA 191

  Fly   189 FGVEANALQDAKSEFFYHNRAIFS-------LTLSRGIDFAIIFMIPALASLARVKLFSRETTKF 246
            ||:|.|.|:...|:|....:.:|:       ||:       .:|..|.|||..|:::...:..:|
  Fly   192 FGIECNTLRTPVSDFRTMGQKVFTDMRHGKLLTM-------FVFSFPKLASRLRMRMMPEDVHQF 249

  Fly   247 IRSSVNYVLKERERTGEKRNDLIDILLALKRE--AAANPGKMSKEVDLDYLVAQAAVFQTAGFET 309
            ....||..:..|||...||||.:::|:.||::  ...:.|::.:.:|:..|.||..||..|||||
  Fly   250 FMRLVNDTIALRERENFKRNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFET 314

  Fly   310 SASTMTMTLYELAKNEALQDRLRQEIVDFFGD-EDHISYERIQEMPYLSQVVNETLRKYPIVGYI 373
            |:|||:..|||||:|:.:|||||.||.....: |..::||.|:.|.||:||::||||.|.:|.::
  Fly   315 SSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHL 379

  Fly   374 ERECSQPAEGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSN---RDNL 435
            ||:....     :.:.....:.:..|..:.:...|.|||...:|:||.:|||||:...   |:::
  Fly   380 ERKALND-----YVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESV 439

  Fly   436 NMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIEWAPTSPVMASKRDIIL 500
            .   ::|||.|||||||||.|.:|:::||..|:...|...||.|...::::|.|.|:.:...|.|
  Fly   440 E---WLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIVLGTVGGIYL 501

  Fly   501 RVEKV 505
            |||::
  Fly   502 RVERI 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	168/486 (35%)
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	168/485 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461125
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800