DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6w1 and Cyp6t1

DIOPT Version :9

Sequence 1:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	197/523 - (37%)
Similarity:	299/523 - (57%)	Gaps:	29/523 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLLLLL--GSLTIVFYIWQRRTLSF--WERHGVKYIRPFPVVGCTREFLTAKVPFFEQIQKFHE 61
            :||.::|  |.|.:|..:|..:.|.|  |.|.||.::...|.||.....|.....|.:|.::.:|
  Fly    18 VLLPVVLRGGCLLVVTIVWLWQILHFWHWRRLGVPFVPAAPFVGNVWNLLRGACCFGDQFRELYE 82

  Fly    62 APGFENEPFVGVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQTDPHNDALGYKNLFFARSPG 126
            :.......|||:.:.|..||::||..|||.:|::.|..|::|...|||..|.:|.:||||::...
  Fly    83 SKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVEDFAQFSSRFETTDPTCDTMGSQNLFFSKYET 147

  Fly   127 WRELRTKISPVFTSGKIKQMYPLMVKIGKNLQDSAERLGSG---TEVQVKDLCSRFTTDLIATIA 188
            |||.....:|.|.:||::.||.|:..||:.|::..|:..||   .|::||.||:.||||:||::|
  Fly   148 WRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCALFTTDIIASLA 212

  Fly   189 FGVEANALQDAKSEFFYHNRAIFSLTLSRGIDFAIIFMIPALASLARVKLFSRETTKFIRSSVNY 253
            ||:||::||:.::||......:......|.:....:|..|.|:......|:|.|..:|:|.|::|
  Fly   213 FGIEAHSLQNPEAEFRRMCIEVNDPRPKRLLHLFTMFFFPRLSHRVGTHLYSEEYERFMRKSMDY 277

  Fly   254 VLKERERTGEKRNDLIDILLALKREAAA-----NPGKMSKEVDLDYLVAQAAVFQTAGFETSAST 313
            ||.:|..:||.|:|||||.|.|||...|     .|         |:..||||....|||:||:||
  Fly   278 VLSQRAESGENRHDLIDIFLQLKRTEPAESIIHRP---------DFFAAQAAFLLLAGFDTSSST 333

  Fly   314 MTMTLYELAKNEALQDRLRQEI-VDFFGDED-HISYERIQEMPYLSQVVNETLRKYPIVGYIERE 376
            :|..|||||||..:|||||.|: ......:| .:|.:.:..:.||.|||:|.||.||...:::|.
  Fly   334 ITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVLRLYPPTAFLDRC 398

  Fly   377 CSQPAEGERFTLEPFHN---MELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNLNMD 438
            |:...   .:.|.|::.   .:|..|..:|:|.:.:|||.||||:||.:|||||::..|...:..
  Fly   399 CNSRT---GYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFSAEQRQQHHPM 460

  Fly   439 AYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIEWAPTSPVMASKRDIILRVE 503
            .|:|||.|||.|||..||.|:.|:||:|||.:.|...|::|:.::.:.|.:.|:.:.....||..
  Fly   461 TYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTLPEMRFDPKAFVLTAHNGTYLRFV 525

  Fly   504 KVS 506
            |.|
  Fly   526 KNS 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	180/479 (38%)
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	173/435 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450327
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	1	1.000	-	-		H59722
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.900