DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6w1 and cyp3c1

DIOPT Version :9

Sequence 1:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_997838.1	Gene:	cyp3c1 / 324340	ZFINID:	ZDB-GENE-030131-3060	Length:	505	Species:	Danio rerio

Alignment Length:	507	Identity:	129/507 - (25%)
Similarity:	258/507 - (50%)	Gaps:	45/507 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPF-FEQIQKFHEAPGFE 66
            |::|:.:|.:::.:|..   .|:::.|:...||.|.||....:......| .|..:|:.:.
Zfish    13 LVVLVITLLLIYGVWPH---GFFKKLGIPGPRPLPFVGTALSYSKGICNFDIECSKKYGKV---- 70

  Fly    67 NEPFVGVYMTHRPALVIRDLELIKTVMIKK-FQYFNNRVLQTDPHNDALG--YKNLFFARSPGWR 128
                .|:|....|.|::.|||:|||:::|. :..|.||   .:.:.|.:|  ...:...:...||
Zfish    71 ----WGIYDGRLPLLLVTDLEMIKTILVKDCYSTFTNR---RNMNPDLVGPFADGITLVKDERWR 128

  Fly   129 ELRTKISPVFTSGKIKQMYPLMVKIGKNLQDSAERLGSGTEVQVKDLCSRFTTDLIATIAFGVEA 193
            .:|:.:||.||||::|:::|:.:........:.|:......:::||:.:.::.|::|:.:|.|:.
Zfish   129 RIRSSLSPYFTSGRLKEIFPIAMTHADRFIKNMEKKDPNLPLKIKDVVAPYSLDVVASSSFSVDF 193

  Fly   194 NALQDAKSEFFYHNRAIFSLTLSRGIDFAIIFMIPALASLAR---VKLFSRETTKFIRSSVNYVL 255
            :::.:....|....::.|::.....: |.::...|:.|:|..   :.:|||.||.|...::..:
Zfish   194 DSINNPDDPFVTSIKSFFNINPLSPL-FLLLAFCPSAANLLAKMGISVFSRSTTDFYYKALRKI- 256

  Fly   256 KERERTGEKRNDLIDILL-------ALKREAAANPGKMSKEVDLDYLVAQAAVFQTAGFETSAST 313
            |:.......|.|.:.:::       .:|..|:..|.|...:.:   :::|:.:|...|:||:::|
Zfish   257 KDEHNESNGRVDFLKLMIQNQIPDDQVKDTASEQPVKGLTDHE---ILSQSFIFILGGYETTSTT 318

  Fly   314 MTMTLYELAKNEALQDRLRQEIVDFFGDEDHISYERIQEMPYLSQVVNETLRKYPIVGYIERECS 378
            ::..||.||.|....::|.:||...|..:..|:|:.:..|.||...::|::|.:|....:||.|.
Zfish   319 LSYLLYNLATNPDCLEKLVEEIDKNFPLDIPITYDALMRMDYLEMAIHESMRVFPAGPRLERVCK 383

  Fly   379 QPAEGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNLNMDAYMPF 443
            :..|        .:.:.:|....:.:....:.|||..|..|.::.||||:..::..:|..|:|||
Zfish   384 KTVE--------INGITIPKNTLVGIPLYVLSRDPDLWESPNEFKPERFSPESKTEINQCAFMPF 440

  Fly   444 GVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIE----WAPTSPV 491
            |:|||||||||..|:..||.:|.:|:.:...||.:|...::    :.|..|:
Zfish   441 GLGPRNCIGMRFALMMMKLLVVKLLQKYTVETCKETQIPVQLNFFFQPKVPI 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	123/476 (26%)
cyp3c1	NP_997838.1	p450	38..496	CDD:278495	123/479 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8421
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.750