Protein Alignment Cyp6w1 and CYP4A22

DIOPT Version :10

• Sequence 1: NP_610206.1
• Gene: Cyp6w1 / 35543
• FlyBaseID: FBgn0033065
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: NP_001010969.2
• Gene: CYP4A22 / 284541
• HGNCID: 20575
• Length: 519
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 143/559 - (25%)
• Similarity: 225/559 - (40%)
• Gaps: 127/559 - (22%)

  Fly     1 MLLLLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFP------VVGCTREFLTAKVPFFEQIQKF 59
            :|:||||.......|:.::..|        |.::.||      :.|..:||     ...:::|:.
Human    24 LLILLLLLIKAAQLYLHRQWLL--------KALQQFPCPPSHWLFGHIQEF-----QHDQELQRI 75

  Fly    60 HEAPGFENEPFVGVYMTHRPALV--------IRDLELIKTVMIKKFQYFNNRVLQTDPHNDA--- 113
            .|.        |..:.:..|..:        :.|.:.:|.::.:           :||.:..
Human    76 QER--------VKTFPSACPYWIWGGKVRVQLYDPDYMKVILGR-----------SDPKSHGSYK 121

  Fly   114 -----LGYKNLFFARSPGWRELRTKISPVFTSGKIKQMYPLMVKIGKNLQDS-AERLGSGTEVQV 172
                 :|| .|.......|.:.|..::|.|.:..:|....||....:.:.|. .|.||..:.::|
Human   122 FLAPRIGY-GLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEV 185

  Fly   173 KDLCSRFTTDLIATIAFG------VEAN------ALQDAKS-------EFFYHNRAIFSLTLSRG 218
            ....|..|.|.|...||.      |:.|      |:.|..|       ..|:.|..|:|||
Human   186 FQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLT---- 246

  Fly   219 IDFAIIFMIPALASLAR-----VKLFSRETTKFIRSSVNYVLKERERTGEKRN---DLIDILLAL 275
                         |..|     .:|..:.|.:.|:.....:.||.|....||.   |.:||||..
Human   247 -------------SAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLA 298

  Fly   276 KREAAANPGKMSKEVDLDYLVAQAAVFQTAGFETSASTMTMTLYELAKNEALQDRLRQEIVDFFG 340
            |.|    .|.:..:.||.   |:...|...|.:|:||.::..||.||.:...|:|.|:||....|
Human   299 KME----NGSILSDKDLR---AEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLG 356

  Fly   341 DEDHISYERIQEMPYLSQVVNETLRKYPIVGYIERECSQPA---EGERFTLEPFHNMELPHGMSI 402
            |...|::..:.:|||.:..:.|.||.||.|..|.||.|.|.   :|.          .||.|:.:
Human   357 DGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGR----------SLPKGIMV 411

  Fly   403 YMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNLNMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHI 467
            .:|...:|.:|:.||:.|.:||.||...:..:.:  |::||..|.|||||.:..:.|.|  :...
Human   412 LLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQHSH--AFLPFSGGSRNCIGKQFAMNQLK--VARA 472

  Fly   468 LRNHRFHTC-DKTIKKIEWAPTSPVMASKRDIILRVEKV 505
            |...||... |.|...|..|..  |:.||..|.||:.::
Human   473 LTLLRFELLPDPTRIPIPMARL--VLKSKNGIHLRLRRL 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_610206.1	CYP6-like	67..498	CDD:410679	125/478 (26%)
CYP4A22	NP_001010969.2	CYP4B-like	72..505	CDD:410771	128/492 (26%)