Protein Alignment Cyp6w1 and CYP4X1

DIOPT Version :10

• Sequence 1: NP_610206.1
• Gene: Cyp6w1 / 35543
• FlyBaseID: FBgn0033065
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: NP_828847.1
• Gene: CYP4X1 / 260293
• HGNCID: 20244
• Length: 509
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 143/552 - (25%)
• Similarity: 238/552 - (43%)
• Gaps: 116/552 - (21%)

  Fly     5 LLLGSL-TIVFYIWQRRTLSFWERHGVKYIRPFPV------VGCTREFLTAKVPFFEQ-IQKFHE 61
            |.||.| .|..|:.::|.|        :.:||||.      :|..:......:...|: |:|:..
Human    22 LALGLLQAIKLYLRRQRLL--------RDLRPFPAPPTHWFLGHQKFIQDDNMEKLEEIIEKYPR 78

  Fly    62 APGFENEPFVGVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQTDPHND--------ALGYKN 118
            |..|...||...:..:.|       :..||::.:           |||.:.        .|| |.
Human    79 AFPFWIGPFQAFFCIYDP-------DYAKTLLSR-----------TDPKSQYLQKFSPPLLG-KG 124

  Fly   119 LFFARSPGWRELRTKISPVFTSGKIKQMYPLMVKIGKNLQDSAERLGS--GTEVQVKDLCSRFTT 181
            |.....|.|.:.|..::|.|....:|....:|....|.:.|..|::.|  .|.|:|.:..:..:.
Human   125 LAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSL 189

  Fly   182 DLIATIAFGVEANALQD------AKSEF-------------FYHNRAIFSLTLSRGIDFAIIFMI 227
            |:|...||..|.|...:      ||:.|             .||:..||.|: .:|..|
Human   190 DIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLS-PQGYRF------ 247

  Fly   228 PALASLARVKLFSRETTKFI---RSSVNYVLKERERTGEKRNDLIDILLALKREAAANPGKMSKE 289
               ..|:||  .::.|...|   :.|:...:|:......|..|.:||:|:.|.|:    |....:
Human   248 ---QKLSRV--LNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDES----GSSFSD 303

  Fly   290 VDLDYLVAQAAVFQTAGFETSASTMTMTLYELAKNEALQDRLRQEIVDFFGDEDHISYERIQEMP 354
            :|:.   ::.:.|..||.:|.|::::..||.||.|...|:|.|:|:....||...|:::::.||.
Human   304 IDVH---SEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMS 365

  Fly   355 YLSQVVNETLRKYPIVGYIERECSQP---AEGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYW 416
            |.:..:.||.|..|.|..|.|:.|:|   .:|          ..||.|:::.:|...:|.:|..|
Human   366 YTTMCIKETCRLIPAVPSISRDLSKPLTFPDG----------CTLPAGITVVLSIWGLHHNPAVW 420

  Fly   417 PDPEKYDPERFNSSNRDNLNMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIK 481
            .:|:.:||.||:..|.|..:..||:||..|.|||||....:::.|:.:..||.:.|. |.|
Human   421 KNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV-TPD---- 480

  Fly   482 KIEWAPTSP-------VMASKRDIILRVEKVS 506
                 ||.|       ::..|..:.|.::|:|
Human   481 -----PTRPLTFPNHFILKPKNGMYLHLKKLS 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_610206.1	CYP6-like	67..498	CDD:410679	122/472 (26%)
CYP4X1	NP_828847.1	CYP4B-like	66..502	CDD:410771	127/493 (26%)
		heme binding region	447..460		7/12 (58%)