DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6w1 and Cyp3a23-3a1

DIOPT Version :9

Sequence 1:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_037237.2	Gene:	Cyp3a23-3a1 / 25642	RGDID:	628626	Length:	502	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	149/524 - (28%)
Similarity:	268/524 - (51%)	Gaps:	56/524 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPFFEQIQKF----HEAPGF 65
            :||..:.::.|.:..||...:::.|:...:|.|..|..       :.::..:.||    |:..|
  Rat    13 VLLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTV-------LNYYMGLWKFDVECHKKYG- 69

  Fly    66 ENEPFVGVYMTHRPALVIRDLELIKTVMIKK-FQYFNNRVLQTDPHNDALGYKNLFFARSPGWRE 129
               ...|::....|...|.|.|:||.|::|: |..|.||   .|.....:..|.:..::...|:.
  Rat    70 ---KIWGLFDGQMPLFAITDTEMIKNVLVKECFSVFTNR---RDFGPVGIMGKAISVSKDEEWKR 128

  Fly   130 LRTKISPVFTSGKIKQMYPLMVKIGKNLQDSAERLGSGTEVQVKDLCSRFTTDLIATIAFGVEAN 194
            .|..:||.||||::|:|:|::.:.|..|.... |...|..|.||::...::.|:|.:.:|||..:
  Rat   129 YRALLSPTFTSGRLKEMFPVIEQYGDILVKYL-RQEKGKPVPVKEVFGAYSMDVITSTSFGVNVD 192

  Fly   195 ALQDAKSEFFYHNRAIFSLTLSRGIDFAII---FMIPALASLARVKLFSRETTKFIRSSVNYVLK 256
            :|.:.|..|....:.:..:.....:..:::   |:.|....| .:.:|.:::.:|.:..| |.:|
  Rat   193 SLNNPKDPFVEKAKKLLRIDFFDPLFLSVVLFPFLTPVYEML-NICMFPKDSIEFFKKFV-YRMK 255

  Fly   257 ER--ERTGEKRNDLIDILLALKREAAANPGKMSKE-----VDLDYLVAQAAVFQTAGFETSASTM 314
            |.  :...:.|.|.:.:::     .|.|..| .||     .|:: :.||:.:|..||:|.::||:
  Rat   256 ETRLDSVQKHRVDFLQLMM-----NAHNDSK-DKESHTALSDME-ITAQSIIFIFAGYEPTSSTL 313

  Fly   315 TMTLYELAKNEALQDRLRQEIVDFFGDEDHISYERIQEMPYLSQVVNETLRKYPIVGYIERECSQ 379
            :..|:.||.:...|.:|::||.....::...:|:.:.||.||..|:|||||.|||...:||.|.:
  Rat   314 SFVLHSLATHPDTQKKLQEEIDRALPNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERVCKK 378

  Fly   380 PAEGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNLNMDAYMPFG 444
            ..|        .:.:.:|.|..:.:.:.|:|||||:||:||::.||||:..|:.:::...|:|||
  Rat   379 DVE--------INGVFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERFSKENKGSIDPYVYLPFG 435

  Fly   445 VGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIEWA------PTSPVMASKRDIILRVE 503
            .|||||||||..|:..||.|..:|:|..|..|.:|...::.:      ||.|::..   ::.|.|
  Rat   436 NGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQGLLQPTKPIILK---VVPRDE 497

  Fly   504 KVSG 507
            .::|
  Rat   498 IITG 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	140/487 (29%)
Cyp3a23-3a1	NP_037237.2	p450	39..492	CDD:278495	140/487 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.870