DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6w1 and Tbxas1

DIOPT Version :9

Sequence 1:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_035669.3	Gene:	Tbxas1 / 21391	MGIID:	98497	Length:	533	Species:	Mus musculus

Alignment Length:	540	Identity:	143/540 - (26%)
Similarity:	253/540 - (46%)	Gaps:	62/540 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLLLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPFFEQIQKFHEAPGF 65
            ::.:.||.:|..:...:.....|..|:.|:::.:|.|.||   ..:..:..|:|...:..|..|
Mouse    15 IVTVTLLVALLALLKWYSMSAFSRLEKLGIRHPKPSPFVG---NLMFFRQGFWESQLELRERYG- 75

  Fly    66 ENEPFVGVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQ-TDPHNDALGYKNLFFARSPGWRE 129
               |..|.|:..|..:||.:.::||.|:::.|..|:||:.. .:|...|   .::...|...|.|
Mouse    76 ---PLCGYYLGRRMHVVISEPDMIKQVLVENFSNFSNRMASGLEPKMVA---DSVLLLRDRRWEE 134

  Fly   130 LRTKISPVFTSGKIKQMYPLMVKIGKNLQDSAERLGSGTE---VQVKDLCSRFTTDLIATIAFGV 191
            :|..:...|:..|:.:|.||:.:..:.|....:|..:..:   :|....|  :|.|::|::|||.
Mouse   135 VRGALMSSFSPEKLDEMTPLISQACELLVAHLKRYAASRDAFNIQRCYCC--YTIDVVASVAFGT 197

  Fly   192 EANALQDAKSEFFYHNRAIFSLTLSRGIDFAIIFMIPALASLARVKLFSR---ETTKFIRSSVNY 253
            :.::....:..|..|.|...:..:.|.:...|:.....:..|||: |.::   |...|..:.:..
Mouse   198 QVDSQNSPEDPFVQHCRRASTFCIPRPLLVLILSFPSIMVPLARI-LPNKNRDELNGFFNTLIRN 261

  Fly   254 V--LKERERTGEKRNDLIDILLALKRE--------------------------AAANPGKMSKEV 290
            |  |::::...|:|.|.:.::|..:..                          ...:|...||..
Mouse   262 VIALRDQQAAEERRRDFLQMVLDAQHSMNSVGVEGFDMVPESLSSSECTKEPPQRCHPTSTSKPF 326

  Fly   291 DLDYLVAQAAVFQTAGFETSASTMTMTLYELAKNEALQDRLRQEIVDFFGDEDHISYERIQE-MP 354
            .:|.:|.||.:|..||.|...:|::...|.||.:...|:||.:|:..|.|......|..:|| :|
Mouse   327 TVDEIVGQAFLFLIAGHEVITNTLSFITYLLATHPDCQERLLKEVDLFMGKHPAPEYHSLQEGLP 391

  Fly   355 YLSQVVNETLRKYPIVGYIERECSQPAE--GERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWP 417
            ||..|::||||.||......||.:|..|  |:|          :|.|..:.::..|:|.||::||
Mouse   392 YLDMVISETLRMYPPAFRFTREAAQDCEVLGQR----------IPAGTVLEIAVGALHHDPEHWP 446

  Fly   418 DPEKYDPERFNSSNRDNLNMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKK 482
            :||.:|||||.:..|.......|:|||.|||:|:|:|||||..||.::.:|...||....:|...
Mouse   447 NPETFDPERFTAEARLQRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLHKFRFEASPETQVP 511

  Fly   483 IEWAPTSPVMASKRDIILRV 502
            ::....| .:..|..:.:::
Mouse   512 LQLESKS-ALGPKNGVYIKI 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	137/504 (27%)
Tbxas1	NP_035669.3	p450	47..528	CDD:365848	137/504 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.750