DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6w1 and Cyp6a16

DIOPT Version :9

Sequence 1:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	189/512 - (36%)
Similarity:	284/512 - (55%)	Gaps:	49/512 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPFFEQIQKFHEAPGFENE 68
            ||||.||......:.|...::||..|:..:||..:.|  ..|....|.:.|.:|:.::|  |...
  Fly     5 LLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFG--HFFRLQSVHYSELLQETYDA--FRGS 65

  Fly    69 PFV-GVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQTDPHNDALGYKNLFFARSPGWRELRT 132
            ..| |.|:..||..|:.||:|:|.|:|:.   |||.|.:...|.|.| ..|||..:...||.|||
  Fly    66 AKVAGTYVFLRPMAVVLDLDLVKAVLIRD---FNNFVDRRSFHGDPL-TANLFNLQGEEWRNLRT 126

  Fly   133 KISPVFTSGKIKQMYPLMVKIGKNLQDSAERL-GS-GTEVQVKDLCSRFTTDLIATIAFGVEANA 195
            |:||.|||||:|.|:..:..:.:.|..:.:.| || |..:::.||.:|:|||:|.:.|||.|.::
  Fly   127 KLSPTFTSGKMKYMFGTVSTVAQQLGGTFDELVGSQGAVLELHDLMARYTTDVIGSCAFGTECSS 191

  Fly   196 LQDAKSEFFYHNRAIFSLTLSRGIDFAIIFMIPALASLAR----VKLFSRETTKFIRSSVNYVLK 256
            |::.::||....|.||. ..:|.|.:. ||.:..|:|||:    |::...:.|||....|...::
  Fly   192 LREPQAEFRQVGRRIFR-NSNRSIRWR-IFKMTYLSSLAKLGLPVRILHPDITKFFNRIVRETVE 254

  Fly   257 ERERTGEKRNDLIDILLALKREAAANPGKMSKEVDLDYLVAQAAVFQTAGFETSASTMTMTLYEL 321
            .|||...:|||.:|:||.|:|:      :..|.:.::.:.|||.||..||||||:|.|:..|:||
  Fly   255 LRERENIRRNDFMDLLLDLRRQ------ENGKGLTMEQMAAQAFVFFVAGFETSSSNMSYALFEL 313

  Fly   322 AKNEALQDRLRQEIVDFFGDEDHISYERIQEMPYLSQVVNETLRKYPIVGYIER------ECSQP 380
            |||:.:|.:||.||.|..|....::||.:.|||||.|.:.|||||||.:..:.|      |...|
  Fly   314 AKNQDVQQKLRMEINDSIGKHGKLTYEAMMEMPYLDQTITETLRKYPALSSLTRLASEDYEIPSP 378

  Fly   381 AEGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNLNMDAYMPFGV 445
            ..|:...||        .|.|:::..:|:|.||:.:|:|.::.||||........:..|::.||.
  Fly   379 DGGDPVVLE--------KGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPTAFLGFGD 435

  Fly   446 GPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIEWAPTSP--VMASKRDIIL 500
            |||||||:|.|.:|.|:||:.:||..||          ...|.||  :..:||::||
  Fly   436 GPRNCIGLRFGRMQVKVGLITLLRRFRF----------SLPPGSPTQLKVTKRNLIL 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	179/482 (37%)
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	179/485 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.970