DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6w1 and cyp-13A1

DIOPT Version :9

Sequence 1:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_001369869.1	Gene:	cyp-13A1 / 188361	WormBaseID:	WBGene00011677	Length:	519	Species:	Caenorhabditis elegans

Alignment Length:	523	Identity:	155/523 - (29%)
Similarity:	239/523 - (45%)	Gaps:	79/523 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPF----FEQIQKFHEAPGFENEPFVGVY 74
            :||||   .:||.|.||.....|||:|.....|....||    .|..:||.:..||..    |..
Worm    19 YYIWQ---WTFWRRRGVVGPMGFPVLGVFLNSLDNNFPFPLQCREWTKKFGKIYGFTE----GTL 76

  Fly    75 MTHRPALVIRDLELIKTVMIKKFQYFNNR---VLQTDPHNDALGYKNLFFARSPGWRELRTKISP 136
            .|    |||.|.||:..|.:.::..|..|   .:|.|...:.  ..|||.|:...|:.||...||
Worm    77 KT----LVISDPELVHEVFVTQYDNFYGRKRNPIQGDSEKEK--RTNLFAAQGFRWKRLRAISSP 135

  Fly   137 VFTSGKIKQMYPLMVKIGKNLQDSAERL--------GSGTEVQVKDLCSRFTTDLIATIAFG--- 190
            .|::..::::|       :.::|||..|        ..|.::.:......||.|:|..||.|
Worm   136 TFSNSSLRKLY-------QTVEDSALELLRHIEKQSAGGKQIDMLKFYQEFTLDVIGRIAMGQTD 193

  Fly   191 --VEANALQDAKSEFFYHNRAIFSLTLSRGIDFAIIFMIPALASLARVKLFS-RETTKFIRSSVN 252
              :..|.:....|:.|..|.|  .|.|..||....:..|.....|..:|:.| |:..:....:::
Worm   194 SQMFKNPIMPIVSKLFQGNFA--KLFLIGGIFPTFLVEIIRQILLKNLKVGSFRKINEITLDAIH 256

  Fly   253 YVLKERERTGEKRN--------DLIDILLALKRE----AAANPGKMSK-------EVDLDYLVAQ 298
            ..:|:||.  :::|        |.||:.|..|.|    ...|.|..||       ::..:.:|.|
Worm   257 NRIKQREE--DQKNGIEIGEPADFIDLFLDAKAEDVEHFGENNGDFSKSTTYTNRQLTTEEIVGQ 319

  Fly   299 AAVFQTAGFETSASTMTMTLYELAKNEALQDRLRQEIVDFFGDEDHISYERIQEMPYLSQVVNET 363
            ..||..|||:|:|.:::...|.||.:..:|.:|::| |:.......::.:::.::.|:..|..|.
Worm   320 CTVFLIAGFDTTALSLSYATYLLATHPEIQKKLQEE-VNRECPNPEVTIDQLSKLKYMECVFKEA 383

  Fly   364 LRKYPIVGYI-ERECSQPAEGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYW-PDPEKYDPER 426
            ||.||:..:. .|.|.:..:        ..||::..|..|.:.|..:|.||..| .|.|.:.|||
Worm   384 LRLYPLGAFANSRRCMRNTK--------LGNMKVEVGTMIQVDTWTLHTDPNIWGDDAEDFKPER 440

  Fly   427 FNSSNRDNL-NMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKT---IKKIEWAP 487
            :.:.|.|.: ....|:|||:|||.||||||..::.|:.||||||...|.|..||   :|.|..|.
Worm   441 WQTPNSDQIYQKSGYIPFGLGPRQCIGMRLAYMEEKILLVHILRKFTFETGAKTEIPLKLIGRAT 505

  Fly   488 TSP 490
            |.|
Worm   506 TQP 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	146/503 (29%)
cyp-13A1	NP_001369869.1	CYP3A-like	64..510	CDD:410678	138/475 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	171	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28638
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm4759
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.760