Protein Alignment Cyp6w1 and CYP26A1

DIOPT Version :10

• Sequence 1: NP_610206.1
• Gene: Cyp6w1 / 35543
• FlyBaseID: FBgn0033065
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: NP_000774.2
• Gene: CYP26A1 / 1592
• HGNCID: 2603
• Length: 497
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 108/527 - (20%)
• Similarity: 214/527 - (40%)
• Gaps: 101/527 - (19%)

  Fly     3 LLLLLGSLTIVFYIWQRRTLSFWERHGVKYIRP----FPVVGCTREFLTAKVPFFEQIQKFHEAP 63
            |||.|.::.    :|....:|..:|.....:.|    ||..|.|.:.:..:..|.:..::.:
Human    18 LLLFLAAIK----LWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRRKY--- 75

  Fly    64 GFENEPFVGVYMTH---RPALVIRDLELIKTVMIKKFQYFNNRVLQTDPHNDA-----LGYKNLF 120
            ||       :|.||   ||.:.:...:.::.:::.:     :|::..  |..|     ||...|.
Human    76 GF-------IYKTHLFGRPTVRVMGADNVRRILLGE-----HRLVSV--HWPASVRTILGSGCLS 126

  Fly   121 FARSPGWRELRTKISPVFTSGKIKQMYPLMV-KIGKNLQD--SAERLGSGTEVQVKDLCSRFTTD 182
            .......::.:..|...|:...::...|::. ::|.:|:.  |....|.....:||.|..|
Human   127 NLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFR---- 187

  Fly   183 LIATIAFGVEANALQDAKSE------FFYHNRAIFSLTLSRGIDFAIIFMIPALASL--ARVKLF 239
            :...|..|.|.....|..||      |....|.:|||.:.  :.|:.::......:|  ||::..
Human   188 IAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPID--VPFSGLYRGMKARNLIHARIEQN 250

  Fly   240 SRETTKFIRSSVNYVLKERERTGEKRNDLIDILLALKREAAANPGKMSKEVDLDYLVAQAAVFQT 304
            .|.....:|:|         ..|:...|.:.:|:       .:..:..:.:|:..|...:.....
Human   251 IRAKICGLRAS---------EAGQGCKDALQLLI-------EHSWERGERLDMQALKQSSTELLF 299

  Fly   305 AGFETSASTMTMTLYELAKNEALQDRLRQE-----IVDFFGDEDHISYERIQEMPYLSQVVNETL 364
            .|.||:||..|..:..|.....:..::|:|     ::.....::.:..|.::::.|:..|:.|||
Human   300 GGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETL 364

  Fly   365 RKYPIVGYIERECSQPAEGERFTLEPF--HNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERF 427
            |..|.|         |. |.|..|:.|  :..::|.|.::..|....|...:.:.:.|:::|:||
Human   365 RLNPPV---------PG-GFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRF 419

  Fly   428 NSSNRDNLNMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCD-------KTIKKIEW 485
            ...:.::.:..:::|||.|.|:|:|.....:..|:..|.:.|:     ||       .|:|
Human   420 MLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARH-----CDWQLLNGPPTMK---- 475

  Fly   486 APTSPVM 492
              |||.:
Human   476 --TSPTV 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_610206.1	CYP6-like	67..498	CDD:410679	93/459 (20%)
CYP26A1	NP_000774.2	CYP26A1	55..490	CDD:410731	98/486 (20%)