Protein Alignment Cyp6w1 and CYP4A11

DIOPT Version :10

• Sequence 1: NP_610206.1
• Gene: Cyp6w1 / 35543
• FlyBaseID: FBgn0033065
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 135/562 - (24%)
• Similarity: 221/562 - (39%)
• Gaps: 133/562 - (23%)

  Fly     1 MLLLLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGC-TREFLTAKVPFFEQIQKFHEAPG 64
            :|:||||....:..|:.::..|        |.::.||   | ...:|...:...:|.|:....
Human    24 LLILLLLLIKAVQLYLHRQWLL--------KALQQFP---CPPSHWLFGHIQELQQDQELQRI-- 75

  Fly    65 FENEPFVGVYMTHRP--------ALVIRDLELIKTVMIKKFQYFNNRVLQTDPHNDA-------- 113
               :.:|..:.:..|        .:.:.|.:.:|.::.:           :||.:..
Human    76 ---QKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGR-----------SDPKSHGSYRFLAPW 126

  Fly   114 LGYKNLFFARSPGWRELRTKISPVFTSGKIKQMYPLMVKIGKNLQDS-AERLGSGTEVQVKDLCS 177
            :|| .|.......|.:.|..::|.|....:|....||....:.:.|. .|.||..:.::|....|
Human   127 IGY-GLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVS 190

  Fly   178 RFTTDLIATIAFGVEANALQDAKSE-------------------FFYHNRAIFSLTLSRGIDFAI 223
            ..|.|.|...||..:.:...|..|:                   .|:.|..|:|||
Human   191 LMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLT--------- 246

  Fly   224 IFMIPALASLAR-----VKLFSRETTKFIRSSVNYVLKERERTGEKRN---DLIDILLALKREAA 280
                    |..|     .:|..:.|.:.|:.....:.||.|....||.   |.:||||..|.|
Human   247 --------SAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKME-- 301

  Fly   281 ANPGKMSKEVDLDYLVAQAAVFQTAGFETSASTMTMTLYELAKNEALQDRLRQEIVDFFGDEDHI 345
              .|.:..:.||.   |:...|...|.:|:||.::..||.||.:...|:|.|:||....||...|
Human   302 --NGSILSDKDLR---AEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASI 361

  Fly   346 SYERIQEMPYLSQVVNETLRKYPIVGYIERECSQPA---EGERFTLEPFHNMELPHGMSIYMSTV 407
            ::..:.:|||.:..:.|.||.||.|..|.||.|.|.   :|.          .||.|:.:.:|..
Human   362 TWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGR----------SLPKGIMVLLSIY 416

  Fly   408 AVHRDPQYWPDPEKYDPERFNSSNRDNLNMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHR 472
            .:|.:|:.||:||.:||.||...:..:.:  |::||..|.|||||.:..:.:.|:...
Human   417 GLHHNPKVWPNPEVFDPFRFAPGSAQHSH--AFLPFSGGSRNCIGKQFAMNELKVATA------- 472

  Fly   473 FHTCDKTIKKIEWAPTSP---------VMASKRDIILRVEKV 505
                 .|:.:.|..|...         |:.||..|.||:.::
Human   473 -----LTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRLRRL 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_610206.1	CYP6-like	67..498	CDD:410679	118/486 (24%)
CYP4A11	NP_000769.2	CYP4B-like	74..505	CDD:410771	119/495 (24%)