DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6w1 and CYP3A4

DIOPT Version :9

Sequence 1:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_059488.2	Gene:	CYP3A4 / 1576	HGNCID:	2637	Length:	503	Species:	Homo sapiens

Alignment Length:	520	Identity:	160/520 - (30%)
Similarity:	278/520 - (53%)	Gaps:	51/520 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPF-FEQIQKFHEAPGFENE 68
            |||....::.|::...:...:::.|:....|.|.:|....:......| .|..:|:.:..||
Human    13 LLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGF--- 74

  Fly    69 PFVGVYMTHRPALVIRDLELIKTVMIKK-FQYFNNRVLQTDPHNDALGYKN--LFFARSPGWREL 130
                 |...:|.|.|.|.::||||::|: :..|.||    .|.. .:|:..  :..|....|:.|
Human    75 -----YDGQQPVLAITDPDMIKTVLVKECYSVFTNR----RPFG-PVGFMKSAISIAEDEEWKRL 129

  Fly   131 RTKISPVFTSGKIKQMYPLMVKIG----KNLQDSAERLGSGTEVQVKDLCSRFTTDLIATIAFGV 191
            |:.:||.|||||:|:|.|::.:.|    :||:..||   :|..|.:||:...::.|:|.:.:|||
Human   130 RSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAE---TGKPVTLKDVFGAYSMDVITSTSFGV 191

  Fly   192 EANALQDAKSEFFYHNRAI--------FSLTLSRGIDFAIIFMIPALASLARVKLFSRETTKFIR 248
            ..::|.:.:..|..:.:.:        |.|:::     ...|:||.|..| .:.:|.||.|.|:|
Human   192 NIDSLNNPQDPFVENTKKLLRFDFLDPFFLSIT-----VFPFLIPILEVL-NICVFPREVTNFLR 250

  Fly   249 SSVNYVLKER-ERTGEKRNDLIDILLALKREAAANPGKMSKEVDLDYLVAQAAVFQTAGFETSAS 312
            .||..:.:.| |.|.:.|.|.:.:::..:........|...:::   ||||:.:|..||:||::|
Human   251 KSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLE---LVAQSIIFIFAGYETTSS 312

  Fly   313 TMTMTLYELAKNEALQDRLRQEIVDFFGDEDHISYERIQEMPYLSQVVNETLRKYPIVGYIEREC 377
            .::..:||||.:..:|.:|::||.....::...:|:.:.:|.||..|||||||.:||...:||.|
Human   313 VLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVC 377

  Fly   378 SQPAEGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNLNMDAYMP 442
            .:..|        .:.|.:|.|:.:.:.:.|:||||:||.:|||:.||||:..|:||::...|.|
Human   378 KKDVE--------INGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTP 434

  Fly   443 FGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIEWAPTSPVMASKRDIILRVEKVSG 507
            ||.|||||||||..|:..||.|:.:|:|..|..|.:|...::.: ...::..::.::|:||...|
Human   435 FGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS-LGGLLQPEKPVVLKVESRDG 498

Fly 508 507
Human 499 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	151/483 (31%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	152/487 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3658
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.800