DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6w1 and Cyp3a16

DIOPT Version :9

Sequence 1:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_031846.2	Gene:	Cyp3a16 / 13114	MGIID:	106099	Length:	504	Species:	Mus musculus

Alignment Length:	522	Identity:	147/522 - (28%)
Similarity:	272/522 - (52%)	Gaps:	57/522 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPFFEQIQKF----HEAPG 64
            |:||..:.::.|.:...|...:::.|:...:|.|       ||...:.:::.:.||    :|..|
Mouse    12 LVLLAIILVLLYRYGTCTHGLFKKQGIPGPKPLP-------FLGTVLNYYKGLWKFDMECYEKYG 69

  Fly    65 FENEPFVGVYMTHRPALVIRDLELIKTVMIKK-FQYFNNRVLQTDPHNDALGYKNLFFARSPGWR 128
                ...|::....|..||.|.|.||.|::|: |..|.||   .|.....:..|::..|:...|:
Mouse    70 ----KTWGLFDGQIPLFVITDPETIKNVLVKECFSVFTNR---QDFFPVGIMSKSISLAKDEEWK 127

  Fly   129 ELRTKISPVFTSGKIKQMYPLMVKIG----KNLQDSAERLGSGTEVQVKDLCSRFTTDLIATIAF 189
            ..|..:||.||||.:|:|:|::.:.|    |.|:..||:   |..|.|||:...::.|:|.:..|
Mouse   128 RYRALLSPTFTSGNLKEMFPVIEQYGDILVKYLRQEAEK---GKPVAVKDVLGAYSMDVIISTTF 189

  Fly   190 GVEANALQDAKSEFFYHNRAIF------SLTLSRGIDFAIIFMIPALASLARVKLFSRETTKFIR 248
            ||..::|.:.:..|..:.:.:.      .|:||    .|:...:..:..:..:.:|.:::.:|.:
Mouse   190 GVNIDSLNNPEDPFVENAKKVLRFDYFDPLSLS----VALFPFLTPIYEMLNICMFPKDSIEFFK 250

  Fly   249 SSVNYVLKERERTGEK-RNDLIDILL-ALKREAAANPGKMSKEVDLDYLVAQAAVFQTAGFETSA 311
            ..|:.:.:.|..:.:| |.|.|.::: |..:....:..|...|::   :.||:.:|..||:||::
Mouse   251 KFVDRMTENRLDSKQKHRVDFIYLMMEAYNKSKDKDSHKALSEIE---ITAQSIIFIFAGYETTS 312

  Fly   312 STMTMTLYELAKNEALQDRLRQEIVDFFGDEDHISYERIQEMPYLSQVVNETLRKYPIVGYIERE 376
            |.::.|:|.||.:..:|.:|::||.:...::...:|:.:..|.||..|:|||||.|||...::|.
Mouse   313 SILSFTVYSLATHPDIQKKLQEEIDEALPNKAPPTYDTVMAMEYLDMVLNETLRLYPITNRLQRV 377

  Fly   377 CSQPAEGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNLNMDAYM 441
            |.:..|        .:.:.:|.|.::.:.:..:|.|||:||:||::.||||:..|:.:::...|:
Mouse   378 CKKDVE--------INGIYIPKGSTVIIPSYVLHHDPQHWPEPEEFQPERFSKENKGSIDPYVYL 434

  Fly   442 PFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKT------IKKIEWAPTSPVMAS--KRDI 498
            |||.|||||||||..|:..||.|:.:|:|..|..|.:|      .:::...|..|::..  .||.
Mouse   435 PFGNGPRNCIGMRFALMNMKLALIKVLQNFSFQPCKETQIPLKLSRELLLQPVKPIVLKVVPRDA 499

  Fly   499 IL 500
            ::
Mouse   500 VI 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	141/492 (29%)
Cyp3a16	NP_031846.2	p450	39..494	CDD:278495	139/486 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720