DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6w1 and Cyp3a13

DIOPT Version :9

Sequence 1:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus

Alignment Length:	521	Identity:	151/521 - (28%)
Similarity:	272/521 - (52%)	Gaps:	51/521 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPFFEQIQKFHEAPGFENEP 69
            :||.:..::.|::...:...:::.|:...:|.|.:|   ..|..:..|:|...:.|:..|    .
Mouse    13 MLLATSLVLLYLYGTHSHGIFKKLGIPGPKPLPFLG---TILAYQKGFWECDIQCHKKYG----K 70

  Fly    70 FVGVYMTHRPALVIRDLELIKTVMIKK-FQYFNNR-------VLQTDPHNDALGYKNLFFARSPG 126
            ..|:|...:|.|.|.|.::||||::|: :..|.||       :|:          |.:..:.:..
Mouse    71 MWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRRFGPVGILK----------KAISISENEE 125

  Fly   127 WRELRTKISPVFTSGKIKQMYPLMVKIGKNL-QDSAERLGSGTEVQVKDLCSRFTTDLIATIAFG 190
            |:.:|..:||.||||::|:|:|::.:....| ::..:.||.|....:||:...::.|:|...:||
Mouse   126 WKRIRALLSPTFTSGRLKEMFPIINQFTDVLVRNMRQGLGEGKPTSMKDIFGAYSMDVITATSFG 190

  Fly   191 VEANALQDAKSEFFYHNRAIFSLTLSRGIDFAII---FMIPALASLARVKLFSRETTKFIRSSVN 252
            |..::|.:.:..|....:.:....:...:..::.   |:.|...:| .|.||.|:...|..:||.
Mouse   191 VNIDSLNNPQDPFVEKIKKLLKFDIFDPLFLSVTLFPFLTPVFDAL-NVSLFPRDVISFFTTSVE 254

  Fly   253 YVLKERERTGEK-RNDLIDILLALKREAAANPGKMSKEVDLDYLVAQAAVFQTAGFETSASTMTM 316
            .:.:.|.:..|| |.|.:.:::..:........|...:|:   :|||:.:|..||:||::|.::.
Mouse   255 RMKENRMKEKEKQRVDFLQLMINSQNYKTKESHKALSDVE---IVAQSVIFIFAGYETTSSALSF 316

  Fly   317 TLYELAKNEALQDRLRQEIVDFFGDEDHISYERIQEMPYLSQVVNETLRKYPIVGYIERECSQPA 381
            .||.||.:..:|.:|:.||.....::...:|:.:.:|.||..|||||||.|||.|.:||.|....
Mouse   317 ALYLLAIHPDVQKKLQDEIDAALPNKAPATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTDV 381

  Fly   382 EGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNLNMDAYMPFGVG 446
            |        .:.:.:|.|..:.:.|.|:|:||:|||:||::.||||:..|:|::|...|:|||.|
Mouse   382 E--------INGLFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSKKNQDSINPYMYLPFGSG 438

  Fly   447 PRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIEWA------PTSPVMASKRDIILRVEKV 505
            ||||||||..|:..|:.||.:|:|.....|.:|...::.:      |.:|::..   ::.|.|.|
Mouse   439 PRNCIGMRFALINMKVALVRVLQNFTVQPCKETEIPLKLSKQGLLQPENPLLLK---VVSRDETV 500

  Fly   506 S 506
            |
Mouse   501 S 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	143/485 (29%)
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	143/480 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3658
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.690