Protein Alignment Cyp6w1 and CYP3A7-CYP3A51P

DIOPT Version :10

• Sequence 1: NP_610206.1
• Gene: Cyp6w1 / 35543
• FlyBaseID: FBgn0033065
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: NP_001243426.2
• Gene: CYP3A7-CYP3A51P / 100861540
• HGNCID: 51504
• Length: 535
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 152/517 - (29%)
• Similarity: 272/517 - (52%)
• Gaps: 53/517 - (10%)

  Fly     5 LLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPF-FEQIQKFHEAPGFENE 68
            |||....|:.|::..||...:::.|:....|.|.:|....|......| .|..:|:.:.
Human    13 LLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKV------ 71

  Fly    69 PFVGVYMTHRPALVIRDLELIKTVMIKK-FQYFNNRVLQTDPHNDALGYKN-LFFARSPGWRELR 131
              .|:|...:|.|.|.|.::||||::|: :..|.||    .|.......|| :..|....|:.:|
Human    72 --WGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNR----RPFGPVGFMKNAISIAEDEEWKRIR 130

  Fly   132 TKISPVFTSGKIKQMYPLMVKIG----KNLQDSAERLGSGTEVQVKDLCSRFTTDLIATIAFGVE 192
            :.:||.|||||:|:|.|::.:.|    :||:..||   :|..|.:|.:...::.|:|.:.:|||.
Human   131 SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAE---TGKPVTLKHVFGAYSMDVITSTSFGVS 192

  Fly   193 ANALQDAKSEFFYHNRAI--------FSLTLSRGIDFAIIFMIPALASLARVKLFSRETTKFIRS 249
            .::|.:.:..|..:.:.:        |.|::.     ...|:.|.|.:| .:.:|.|:...|:..
Human   193 IDSLNNPQDPFVENTKKLLRFNPLDPFVLSIK-----VFPFLTPILEAL-NITVFPRKVISFLTK 251

  Fly   250 SVNYVLKER-ERTGEKRNDLIDILLALKREAAANPGKMSKEVDLDYLVAQAAVFQTAGFETSAST 313
            ||..:.:.| :.|.:.|.|.:.:::..:....:...|...:::   |:||:.:|..||:||::|.
Human   252 SVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLE---LMAQSIIFIFAGYETTSSV 313

  Fly   314 MTMTLYELAKNEALQDRLRQEIVDFFGDEDHISYERIQEMPYLSQVVNETLRKYPIVGYIERECS 378
            ::..:||||.:..:|.::::||.....::...:|:.:.::.||..|||||||.:|:...:||.|.
Human   314 LSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCK 378

  Fly   379 QPAEGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNLNMDAYMPF 443
            :..|        .:.|.:|.|:.:.:.:..:|.||:||.:|||:.||||:..|:||::...|.||
Human   379 KDVE--------INGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPF 435

  Fly   444 GVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKT--IKKIEWAPTSPVMASKRDIILRVE 503
            |.|||||||||..|:..||.||.:|:|..|..|.:|  ..|:.:   ..::.:::.|:|:.|
Human   436 GSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRF---GGLLLTEKPIVLKAE 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_610206.1	CYP6-like	67..498	CDD:410679	134/447 (30%)
CYP3A7-CYP3A51P	NP_001243426.2	CYP3A	67..492	CDD:410743	136/459 (30%)