Protein Alignment Cyp6w1 and cyp3a4

DIOPT Version :10

• Sequence 1: NP_610206.1
• Gene: Cyp6w1 / 35543
• FlyBaseID: FBgn0033065
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: XP_002943949.2
• Gene: cyp3a4 / 100494419
• XenbaseID: XB-GENE-984218
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 519
• Identity: 150/519 - (28%)
• Similarity: 264/519 - (50%)
• Gaps: 55/519 - (10%)

  Fly     2 LLLLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPF-FEQIQKFHEAPGF 65
            :||.:|..|.:::.||   ....:::.|:....|.|.:|...||....:.| .|..:|:..
 Frog    13 ILLAVLLVLILLYGIW---PYGLFKKMGIPGPTPLPFIGTFLEFRKGMIQFDIECFKKYGR---- 70

  Fly    66 ENEPFVGVYMTHRPALVIRDLELIKTVMIKK-FQYFNNRVLQTDPHNDALG---YKNLFFARSPG 126
                ..|:|...:|.|.|.|..:|||:::|: :..|.||      .|..|.   ...:..|....
 Frog    71 ----MWGMYDGRQPVLAIMDPAIIKTILVKECYTNFTNR------RNFGLNGPLESAITVAEDEQ 125

  Fly   127 WRELRTKISPVFTSGKIKQMYPLMVK----IGKNLQDSAERLGSGTEVQVKDLCSRFTTDLIATI 187
            |:.:|:.:||.|||||:|:|:.:|..    :.||:|.|.::   ......||:...::.|:|.:.
 Frog   126 WKRIRSVLSPTFTSGKLKEMFQIMKDYSDILVKNVQVSVDK---DEPCATKDVIGAYSMDVITST 187

  Fly   188 AFGVEANALQDAKSEFFYHNRAIFSL-TLSRGIDFAIIF-MIPALASLARVKLFSRETTKFIRSS 250
            :|.|..::||:..:.|..|.:.:... .||..|.||:|| .:..:..:..:..|.::.|:|..::
 Frog   188 SFSVNIDSLQNPSNPFVIHIKNLLKTGFLSPVIIFAVIFPFLRPIFEVLNISFFPKDFTQFFMNA 252

  Fly   251 VNYVLKERERTGEK--RNDLIDILLALKREAAANPGKMSKEVDLDYLVAQAAVFQTAGFETSAST 313
            |. ..:|:.:.|:.  |.||:.:::........:.....|.:....::||:.:|..||:||:::.
 Frog   253 VT-SFREKRKKGDHSGRVDLLQLMVDSGTTEGNDSSNQHKALTDAEIMAQSLIFIFAGYETTSTA 316

  Fly   314 MTMTLYELAKNEALQDRLRQEIVDFFGDEDHISYERIQEMPYLSQVVNETLRKYPIVGYIERECS 378
            ::...|.||.:..:|.:|.:||..|..|:...:|:.:.:|.||..|:.||||.:|..|.:||...
 Frog   317 LSYLFYNLATHPDVQQKLHEEIDSFLPDKASPTYDILMQMEYLDMVIQETLRLFPPAGRLERVSK 381

  Fly   379 QPAEGERFTLEPFHNMELPHGMSIYMSTVA------VHRDPQYWPDPEKYDPERFNSSNRDNLNM 437
            |             |:|: :|:||...|||      :.|||:|||:||::.||||:..||.....
 Frog   382 Q-------------NVEI-NGVSIPKGTVAMIPAYVLQRDPEYWPEPEEFRPERFSKENRATQTP 432

  Fly   438 DAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIEWAPTSPVMASKRDIILR 501
            ..::|||.|||||||:|..||..|:.:..:|:|.....|.:|:..:|:: |..|:..|:.|:|:
 Frog   433 FTFLPFGDGPRNCIGLRFALLSMKVAIATLLQNFSVRPCAETLIPMEFS-TIGVLQPKKPIVLK 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6w1	NP_610206.1	CYP6-like	67..498	CDD:410679	133/448 (30%)
cyp3a4	XP_002943949.2	CYP3A	67..495	CDD:410743	135/460 (29%)