Protein Alignment EcR and NR1I3

DIOPT Version :9

• Sequence 1: NP_001163061.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: XP_005245750.1
• Gene: NR1I3 / 9970
• HGNCID: 7969
• Length: 429
• Species: Homo sapiens
• Alignment Length: 361
• Identity: 95/361 - (26%)
• Similarity: 150/361 - (41%)
• Gaps: 90/361 - (24%)

  Fly   289 RRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRREKKAQ--- 350
            ||:|:||....|.|..:||:....||.|..|||:|||..|||.:.::.....|: ||.|:||
Human   108 RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALAL-RRAKQAQRRA 171

  Fly   351 --------KEKDKMTTSPSSQHGGN-GSLASGGGQDFVKKEILDLMTCEPPQHATIPLLPDEILA 406
                    ||::::..:....|..: |::.    :.||:        ..||.|..|...|
Human   172 QQTPVQLSKEQEELIRTLLGAHTRHMGTMF----EQFVQ--------FRPPAHLFIHHQP----- 219

  Fly   407 KCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQTDVSFRHITEITILTV 471
                  :|:     ||.:..|:                                .|..:|....|
Human   220 ------LPT-----LAPVLPLV--------------------------------THFADINTFMV 241

  Fly   472 QLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYT-----RDS 531
            ..:::|.|.||.|..:|.||||:|||..:.|:..:.:...:...:.: |......||     |.|
Human   242 LQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQN-FLCGPLRYTIEDGARVS 305

  Fly   532 YKMAGMADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS------DRPGLEKAQLVEAIQSYYI 590
            ..:....:.:|.|.||...:..:::...||.||.|:.:||      ||||:.:...::.:|....
Human   306 PTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQRDEIDQLQEEMA 370

  Fly   591 DTLRIYI--LNRHCGDSMSLVFYAKLLSILTELRTL 624
            .||:.||  ..|...|..   .|||||.:|.|||::
Human   371 LTLQSYIKGQQRRPRDRF---LYAKLLGLLAELRSI 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	27/72 (38%)
		NR_LBD_EcR	420..652	CDD:132736	56/218 (26%)
NR1I3	XP_005245750.1	NR_DBD_like	<108..154	CDD:295381	21/45 (47%)
		NR_LBD_PXR_like	178..427	CDD:132732	68/290 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010