DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EcR and NR1D1

DIOPT Version :9

Sequence 1:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_068370.1	Gene:	NR1D1 / 9572	HGNCID:	7962	Length:	614	Species:	Homo sapiens

Alignment Length:	684	Identity:	161/684 - (23%)
Similarity:	243/684 - (35%)	Gaps:	214/684 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 TIIPINGNAN------GNGGSTNGQYVPGATNLGALANGMLNGGFNGMQQQIQNGHGLINSTTPS 152
            |.:..|.|..      |:.||:     |..|:..:|.:...||.|..:.|...       :..|.
Human     2 TTLDSNNNTGGVITYIGSSGSS-----PSRTSPESLYSDNSNGSFQSLTQGCP-------TYFPP 54

  Fly   153 TPT-------------TPLHLQQNLGGAGGGGIGGMGILHHANGTPNGLIGVVGGGGGVGLGVGG 204
            :||             .|..|..: |................||:|.|.:.|
Human    55 SPTGSLTQDPARSFGSIPPSLSDD-GSPSSSSSSSSSSSSFYNGSPPGSLQV------------- 105

  Fly   205 GGVGGLGMQHTPRSDSVNSISSGRDDLSPSSS------LNGYSANESCDAKKSKKGPAPRVQEEL 263
                  .|:.:.|             :|||.|      |||...                    |
Human   106 ------AMEDSSR-------------VSPSKSTSNITKLNGMVL--------------------L 131

  Fly   264 CLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVY--CCKFGRACEMDMYMRRKCQECRLKKCLA 326
            |.||||.|||:||....|||||||||||:.::..|  |.| ...|.:....|.:||:||.||||:
Human   132 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLK-NENCSIVRINRNRCQQCRFKKCLS 195

  Fly   327 VGMRPECV----VP---------ENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDF 378
            |||..:.|    :|         |.|.||.....:...: ..:.||| :||...|.:........
Human   196 VGMSRDAVRFGRIPKREKQRMLAEMQSAMNLANNQLSSQ-CPLETSP-TQHPTPGPMGPSPPPAP 258

  Fly   379 VKKEILDLMTCEPPQHATIPLLP------DEILAKCQARNIPSLTY------------------- 418
            |...::..  .:.||..|.|..|      ::::::....:....||
Human   259 VPSPLVGF--SQFPQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHDKLGSSPGNFNANHASG 321

  Fly   419 ----------------------NQLAV---------------IYKLIW------------YQDGY 434
                                  |.||.               .|...|            ..:|:
Human   322 SPPATTPHRWENQGCPPAPNDNNTLAAQRHNEALNGLRQAPSSYPPTWPPGPAHHSCHQSNSNGH 386

  Fly   435 -----------------EQPSEEDLRRIMSQPDENESQTDVSFRHITEI-------TILTVQLIV 475
                             ..|.:.:.:.::.....|......|.|.:.||       ....|:.:|
Human   387 RLCPTHVYAAPEGKAPANSPRQGNSKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVV 451

  Fly   476 EFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADN 540
            ||||.:|.|..:.|.||:|||||.:.||:|:|.|..::....::.|.:..:|:.......||.|.
Human   452 EFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGDL 516

  Fly   541 IEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLRIYIL-NRHCG 603
            :..:..|..::.|:.:...|..|.||:|:.| ||.|:|.:..||.:|...:..||..:| ||...
Human   517 LSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPLE 581

  Fly   604 DSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKL 637
            .|.    :.|||..|.:||||.|.::|...|.::
Human   582 TSR----FTKLLLKLPDLRTLNNMHSEKLLSFRV 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	44/104 (42%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	69/271 (25%)
NR1D1	NP_068370.1	Modulating	1..128		32/170 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..119		29/161 (18%)
		Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000250\|UniProtKB:Q3UV55	1..70		16/79 (20%)
		Crucial for activation of GJA1. /evidence=ECO:0000250	49..284		76/299 (25%)
		NR_DBD_REV_ERB	127..215	CDD:143540	41/108 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	233..285		12/55 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..345		0/33 (0%)
		NR_LBD	418..611	CDD:325017	63/196 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157575
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840