Protein Alignment EcR and NR1I2

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_071285.1
• Gene: NR1I2 / 8856
• HGNCID: 7968
• Length: 473
• Species: Homo sapiens
• Alignment Length: 497
• Identity: 136/497 - (27%)
• Similarity: 225/497 - (45%)
• Gaps: 93/497 - (18%)

  Fly   210 LGMQHTPRSDSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKKG-PAPRVQEE-----LCLVCG 268
            |...| ||....|.      ::.|..|.| ::....|:..:|..| |:....||     :|.|||
Human    28 LASNH-PRGPEANL------EVRPKESWN-HADFVHCEDTESVPGKPSVNADEEVGGPQICRVCG 84

  Fly   269 DRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGR-ACEMDMYMRRKCQECRLKKCLAVGMRPE 332
            |:|:|||:|.:|||||||||||::.::|...|.|.: |||:....||:||.|||:|||..||:.|
Human    85 DKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKE 149

  Fly   333 CVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMT--------- 388
            .:: .::...:||....:|:.::..|.|....|....      |..:.:|::|...
Human   150 MIM-SDEAVEERRALIKRKKSERTGTQPLGVQGLTEE------QRMMIRELMDAQMKTFDTTFSH 207

  Fly   389 -------------CEPPQHATIPLLPDEILAKCQARNIPSLTYN-QLAVIYKLIWYQDGYEQPSE 439
                         ||.|:....|...:........:::.||..: ||......:|   .|:.|::
Human   208 FKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVW---NYKPPAD 269

  Fly   440 EDLRRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVM 504
            ...:.|.|           ...|:.:::....:.|:.|||.:..|..:|.||||:|||..:.|:.
Human   270 SGGKEIFS-----------LLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELC 323

  Fly   505 MLRMARRYDHSSDSIFFANNRSYT--RDSYKMAGMADN-----IEDLLHFCRQMFSMKVDNVEYA 562
            .||.        :::|.|...::.  |.||.:...|..     :|.:|.|...:..:::...||.
Human   324 QLRF--------NTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYV 380

  Fly   563 LLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLRIYI-LNRHCGDSMSLVFYAKLLSILTELRTLG 625
            |:.||.:|| ||||:.:.::|:.:|..:..||:.|| .||  ........:.|::::|||||::.
Human   381 LMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNR--PQPAHRFLFLKIMAMLTELRSIN 443

  Fly   626 NQNAEMCFSLKLKNRKLPKFLEEIWDVHAI-PPSVQSHLQIT 666
            .|:.:.              |..|.|:|.. .|.:|....||
Human   444 AQHTQR--------------LLRIQDIHPFATPLMQELFGIT 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	44/95 (46%)
		NR_LBD_EcR	420..652	CDD:132736	61/240 (25%)
NR1I2	NP_071285.1	NR_DBD_PXR	79..166	CDD:143536	42/87 (48%)
		NR_LBD_PXR_like	182..467	CDD:132732	74/328 (23%)