Protein Alignment EcR and Nr1i2

DIOPT Version :9

• Sequence 1: NP_001163061.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_443212.1
• Gene: Nr1i2 / 84385
• RGDID: 69057
• Length: 431
• Species: Rattus norvegicus
• Alignment Length: 441
• Identity: 117/441 - (26%)
• Similarity: 197/441 - (44%)
• Gaps: 90/441 - (20%)

  Fly   262 ELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGR-ACEMDMYMRRKCQECRLKKCL 325
            ::|.||||:|:|||:|.:|||||||||||::.::....|.|.: .||:....||:||.|||:|||
  Rat    36 QICRVCGDKANGYHFNVMTCEGCKGFFRRAMKRNVRLRCPFRKGTCEITRKTRRQCQACRLRKCL 100

  Fly   326 AVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLM--- 387
            ..||:.|.:: .:....:||....:|:::|:...|.   ||.|....   |..:.:|::|..
  Rat   101 ESGMKKEMIM-SDAAVEQRRALIKRKKREKIEAPPP---GGQGLTEE---QQALIQELMDAQMQT 158

  Fly   388 -------------------TCEPPQHATIPLLPDEIL-AKCQARNIPSLTYNQLAVIYKLIWYQD 432
                               .||.|:.....||.|... ::....::|.....||......||
  Rat   159 FDTTFSHFKDFRLPAVFHSDCELPEVLQASLLEDPATWSQIMKDSVPMKISVQLRGEDGSIW--- 220

  Fly   433 GYEQPSEEDLRRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLK 497
            .|:.||:.|.:.|:.           ...|:.:::....:.::.|||.:..|.::|.||||:|||
  Rat   221 NYQPPSKSDGKEIIP-----------LLPHLADVSTYMFKGVINFAKVISHFRELPIEDQISLLK 274

  Fly   498 ACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADNIED------------LLHFCRQ 550
            ..:.|:.:||....:|..:             .:::...:|...||            |:.|...
  Rat   275 GATFEMCILRFNTMFDTET-------------GTWECGRLAYCFEDPNGGFQKLLLDPLMKFHCM 326

  Fly   551 MFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSL--VFYA 612
            :..:::...||.|:.||.:|| ||||:.:..:|:.:|..:..||:.||   .|......  ..:.
  Rat   327 LKKLQLREEEYVLMQAISLFSPDRPGVVQRSVVDQLQERFALTLKAYI---ECSRPYPAHRFLFL 388

  Fly   613 KLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVHAIPPSVQSHL 663
            |::::|||||::..|..:.              |..|.|.|.....:...|
  Rat   389 KIMAVLTELRSINAQQTQQ--------------LLRIQDTHPFATPLMQEL 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	40/89 (45%)
		NR_LBD_EcR	420..652	CDD:132736	58/246 (24%)
Nr1i2	NP_443212.1	NR_DBD_like	37..124	CDD:413390	40/87 (46%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250	63..89		6/25 (24%)
		Hinge	105..142		9/40 (23%)
		NR_LBD	140..425	CDD:416257	70/331 (21%)
		Hyperforin binding, agonist. /evidence=ECO:0000250|UniProtKB:O75469	282..285		1/2 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351565
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940