Protein Alignment EcR and Thra

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_112396.2
• Gene: Thra / 81812
• RGDID: 3857
• Length: 492
• Species: Rattus norvegicus
• Alignment Length: 531
• Identity: 139/531 - (26%)
• Similarity: 216/531 - (40%)
• Gaps: 123/531 - (23%)

  Fly   243 NESCDAKKSKKGPAPRV--QEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKS--AVYCCKFG 303
            |..|..|.|..|..|..  ::|.|:||||:|:||||..:|||||||||||::.|:  ..|.||:.
  Rat    30 NGQCPLKSSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYD 94

  Fly   304 RACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRR---EKKAQKEKDKMTTS------ 359
            ..|.:|...|.:||.||.|||:||||..:.|:.:::...||:   :.:.::.|::|..|
  Rat    95 SCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPE 159

  Fly   360 PSSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIPLLPDEILAKCQARNIPSLTYNQLAVI 424
            |:                   .|..||:......|.:         ...|..:
  Rat   160 PT-------------------PEEWDLIHVATEAHRS---------TNAQGSH------------ 184

  Fly   425 YKLIWYQDGYEQPSEEDLRRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQ 489
                |.|.....|.:.....|:|.||.::...: :|...|:|....:..:|:|||.||.|:::|.
  Rat   185 ----WKQRRKFLPDDIGQSPIVSMPDGDKVDLE-AFSEFTKIITPAITRVVDFAKKLPMFSELPC 244

  Fly   490 EDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADNIEDLLHFCRQMFSM 554
            ||||.|||.|..|:|.||.|.|||..||::..:...:..|:..|..|:....:.:....:.:.:.
  Rat   245 EDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAF 309

  Fly   555 KVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLRIYILNR-----HCGDSMSLVFYAK 613
            .:|:.|.|||.|:::.| ||.||.....:|..|..|:.....|:.:|     |        |:.|
  Rat   310 NLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPH--------FWPK 366

  Fly   614 LLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVHAIPPSVQSHLQITQEENERLERAER 678
            ||.          :..|:..|:..|.............||   |..|..|.:...:..::.:.|:
  Rat   367 LLM----------KEREVQSSILYKGAAAEGRPGGSLGVH---PEGQQLLGMHVVQGPQVRQLEQ 418

  Fly   679 MRASVGGAITAGIDCDSASTSAAAAAAQHQPQPQPQ------------------------PQPSS 719
            .....|              |......|||....||                        .:.||
  Rat   419 QFGEAG--------------SLRGPVLQHQSPKSPQQRLLELLHRSGILHSRAVCGEDDSSEASS 469

  Fly   720 LTQNDSQHQTQ 730
            |:.:.|...|:
  Rat   470 LSSSSSDEDTE 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	43/94 (46%)
		NR_LBD_EcR	420..652	CDD:132736	63/237 (27%)
Thra	NP_112396.2	Modulating	1..52		6/21 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		1/2 (50%)
		NR_DBD_TR	52..138	CDD:143519	42/85 (49%)
		NR_LBD_TR	162..370	CDD:132733	65/251 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	457..492		5/24 (21%)