DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EcR and nr1h2

DIOPT Version :9

Sequence 1:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001072853.1	Gene:	nr1h2 / 780314	XenbaseID:	XB-GENE-482950	Length:	441	Species:	Xenopus tropicalis

Alignment Length:	447	Identity:	176/447 - (39%)
Similarity:	255/447 - (57%)	Gaps:	56/447 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 RSDSVNSISSGRDDLSPSSSLNGYSANESCD-AKKSKKGPAPR-VQEELCLVCGDRASGYHYNAL 279
            ||:|..|.|...::..|.:...|.|.:.:.: .:|.||||||: :..|:|.||||:|||:|||.|
Frog    40 RSESQGSSSLPNENEVPGTDGEGSSQSAAEEPERKRKKGPAPKMLGNEVCSVCGDKASGFHYNVL 104

  Fly   280 TCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKR 344
            :||||||||||||.|:|.|.||....|:||||||||||||||:||...|||.:||:.|.|.
Frog   105 SCEGCKGFFRRSVIKNAQYTCKNNGKCQMDMYMRRKCQECRLRKCREAGMREQCVLSEEQI---- 165

  Fly   345 REKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIPLLPDEILAKCQ 409
            |.||.:|:::...|.|||                                |.:|..|      |.
Frog   166 RSKKIKKQQEDDVTRPSS--------------------------------ALVPPSP------CM 192

  Fly   410 -ARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIM-----SQPDENESQTDVSFRHITEITI 468
             ::.:..||..|..:|.:|:..|....:.|..|..::.     |.|:..|::.. .|.|.||:.|
Frog   193 LSQEVVQLTPQQEKMIQQLVSAQQQCNKRSFSDQPKVTPWPLGSDPNSREARQQ-RFAHFTELAI 256

  Fly   469 LTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYK 533
            ::||.||:|||.:|.|.::.:||||.||||.:.|:|:|..||||:|.::.|.|..:.:|::|.:.
Frog   257 ISVQEIVDFAKQIPGFLELSREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFH 321

  Fly   534 MAGM-ADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLRIY 596
            .||: .:.|..:..|.|.|..|::|:.|||||.||.||| |||.::..||||.:|..|::.|..|
Frog   322 RAGLQVEFINPIFEFSRGMRQMQLDDAEYALLIAINIFSADRPNVQNHQLVENLQLPYVEALHSY 386

  Fly   597 ILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVH 653
            ...:...|.:   .:.::|..|..||||.:.::|..|:|:|:::|||..|.||||||
Frog   387 TRIKRPQDHL---MFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVH 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	57/89 (64%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	90/238 (38%)
nr1h2	NP_001072853.1	NR_DBD_LXR	69..169	CDD:143534	62/103 (60%)
nr1h2	NP_001072853.1	NR_LBD_LXR	204..439	CDD:132752	90/238 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4986
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21397
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1137281at2759
OrthoFinder	1	1.000	-	-		FOG0005880
OrthoInspector	1	1.000	-	-		otm48688
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4552
SonicParanoid	1	1.000	-	-		X4275
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.050