Protein Alignment EcR and VDR

DIOPT Version :9

• Sequence 1: NP_001163061.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001351014.1
• Gene: VDR / 7421
• HGNCID: 12679
• Length: 494
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 156/571 - (27%)
• Similarity: 237/571 - (41%)
• Gaps: 117/571 - (20%)

  Fly   244 ESCDAKKSKKGP------APRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKF 302
            |:..|..|...|      .||:    |.||||||:|:|:||:||||||||||||:.:.|::.|.|
Human     2 EAMAASTSLPDPGDFDRNVPRI----CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPF 62

  Fly   303 GRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKR----REKKAQKEKDKMTTSPSSQ 363
            ...|.:....||.||.||||:|:.:||..|.::.:.:...||    :.|:.:..||.:....|.:
Human    63 NGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEE 127

  Fly   364 HGGNGSLASGGGQDFVKKEILDLMTCEPP--------QHATIPLLPDEILAKCQARNIPSLTYNQ 420
            .....::..............|.....||        .|.:.|          .:|:.||.:.:.
Human   128 QQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRP----------NSRHTPSFSGDS 182

  Fly   421 LAVIY-KLIWYQDGYEQPSEEDLRRIMSQPDENESQTDVSFR------HITEITILTVQLIVEFA 478
            .:... ..|...|..:..|..:|.  :|:.|.::....:...      |:.::...::|.::.||
Human   183 SSSCSDHCITSSDMMDSSSFSNLD--LSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFA 245

  Fly   479 KGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSY---TRDSYKMAGMADN 540
            |.:|.|..:..||||.|||:.:.||:|||....:. ..|..:...|:.|   ..|..|.....:.
Human   246 KMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFT-MDDMSWTCGNQDYKYRVSDVTKAGHSLEL 309

  Fly   541 IEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGD 604
            ||.|:.|...:..:.:...|:.||.||.|.| ||||::.|.|:||||....:||:.||..||...
Human   310 IEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPP 374

  Fly   605 SMSLVFYAKLLSILTELRTLGNQNAEM--CF------SLKLKNRKLPKFLEEIWDVHAIPPSVQS 661
            ...|: |||::..|.:||:|..::::.  |.      |:||....|..|..||
Human   375 GSHLL-YAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEI------------ 426

  Fly   662 HLQITQEENERLERAERMRASVGGAITA-GIDCDSASTSAAAAAAQHQPQPQPQPQPSSLTQNDS 725
                               : :|..:.. |..|.|.:|..|.........|.|....:
Human   427 -------------------SXLGQPVAVPGWGCSSRATCQARGWRLLSSPPHPVWGSA------- 465

  Fly   726 QHQTQPQLQPQLPPQLQGQLQPQLQPQLQTQLQPQIQPQPQLLPVS-APVP 775
                     |.|||.|  ..||.|.|         :||.|  .|.. :|||
Human   466 ---------PPLPPPL--STQPILSP---------VQPNP--FPAGFSPVP 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	42/93 (45%)
		NR_LBD_EcR	420..652	CDD:132736	73/250 (29%)
VDR	NP_001351014.1	NR_DBD_VDR	16..122	CDD:143513	46/109 (42%)
		Hinge	97..126		5/28 (18%)
		NR_LBD_VDR	124..426	CDD:132731	80/315 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..190		5/41 (12%)
		Vitamin D3 binding	227..237		1/9 (11%)
		Vitamin D3 binding	271..278		3/6 (50%)
		9aaTAD. /evidence=ECO:0000269|PubMed:30468856	416..424		2/7 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157554
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940