Protein Alignment EcR and NR1H2

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_009052.4
• Gene: NR1H2 / 7376
• HGNCID: 7965
• Length: 460
• Species: Homo sapiens
• Alignment Length: 449
• Identity: 169/449 - (37%)
• Similarity: 248/449 - (55%)
• Gaps: 59/449 - (13%)

  Fly   227 GRDDLSPSSSLNGYSAN-ESCDAKKSKKGPAPR-VQEELCLVCGDRASGYHYNALTCEGCKGFFR 289
            |.|:.|.:.|.:....: |....:|.||||||: :..|||.||||:|||:|||.|:|||||||||
Human    48 GTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFR 112

  Fly   290 RSVTKSAV--YCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRREKKAQKE 352
            |||.:...  |.|:.|..|:||.:||||||:|||:||...|||.:||:.|.| ..|::.:|.|:|
Human   113 RSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQ-IRKKKIRKQQQE 176

  Fly   353 KDKMTTSPSSQHGGNGSLASG----------GGQDFVKKEILDLMTCEPPQHATIPLLPDEILA- 406
            ....:.||....|.:.| |||          |.|...:.|.:.|...:       .|:..:::|
Human   177 SQSQSQSPVGPQGSSSS-ASGPGASPGGSEAGSQGSGEGEGVQLTAAQ-------ELMIQQLVAA 233

  Fly   407 --KCQARNI---PSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQTDVSFRHITEI 466
              :|..|:.   |.:|...|..            .|...|.|:             ..|.|.||:
Human   234 QLQCNKRSFSDQPKVTPWPLGA------------DPQSRDARQ-------------QRFAHFTEL 273

  Fly   467 TILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDS 531
            .|::||.||:|||.:|.|.::.:||||.||||.:.|:|:|..||||:|.::.|.|..:.:|::|.
Human   274 AIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDD 338

  Fly   532 YKMAGM-ADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLR 594
            :..||: .:.|..:..|.|.|..:.:|:.|||||.||.||| |||.:::...|||:|..|::.|.
Human   339 FHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALL 403

  Fly   595 IYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVH 653
            .|...:...|.:.   :.::|..|..||||.:.::|..|:|:|:::|||..|.||||||
Human   404 SYTRIKRPQDQLR---FPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVH 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	52/91 (57%)
		NR_LBD_EcR	420..652	CDD:132736	83/233 (36%)
NR1H2	NP_009052.4	Transactivation AF-1, required for ligand-independent transactivation function. /evidence=ECO:0000269|PubMed:25661920	1..85		12/36 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..78		9/29 (31%)
		NR_DBD_LXR	67..169	CDD:143534	58/102 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..216		12/47 (26%)
		Transactivation AF-2, required for ligand-dependent transactivation function, mediates interaction with CCAR2. /evidence=ECO:0000269|PubMed:25661920	219..460		93/276 (34%)
		NR_LBD_LXR	223..458	CDD:132752	89/269 (33%)