Protein Alignment EcR and THRB

DIOPT Version :9

• Sequence 1: NP_001163061.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_000452.2
• Gene: THRB / 7068
• HGNCID: 11799
• Length: 461
• Species: Homo sapiens
• Alignment Length: 455
• Identity: 143/455 - (31%)
• Similarity: 211/455 - (46%)
• Gaps: 88/455 - (19%)

  Fly   219 DSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKKGPAPRV--QEELCLVCGDRASGYHYNALTC 281
            |.||       |.|.||:....:..:.|      ||..|..  ::|||:||||:|:||||..:||
Human    73 DDVN-------DQSVSSAQTFQTEEKKC------KGYIPSYLDKDELCVVCGDKATGYHYRCITC 124

  Fly   282 EGCKGFFRRSVTKS--AVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKR 344
            |||||||||::.|:  ..|.||:...|.:|...|.:|||||.|||:.|||..:.|:.:::...||
Human   125 EGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKR 189

  Fly   345 ------REKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIPLLPDE 403
                  |||:.::|..|                |.|.:.....|..:|:......|
Human   190 KLIEENREKRRREELQK----------------SIGHKPEPTDEEWELIKTVTEAH--------- 229

  Fly   404 ILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQTDVSFRHITEITI 468
            :....|..:                |.|.....|.:.....|::.|:..:...: :|.|.|:|..
Human   230 VATNAQGSH----------------WKQKRKFLPEDIGQAPIVNAPEGGKVDLE-AFSHFTKIIT 277

  Fly   469 LTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYK 533
            ..:..:|:|||.||.|.::|.||||.|||.|..|:|.||.|.|||..|:::......:.||...|
Human   278 PAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLK 342

  Fly   534 MAGM---ADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIF-SDRPGLEKAQLVEAIQSYYIDTLR 594
            ..|:   :|.|.||   ...:.|..:|:.|.|||.|:::. ||||||...:.:|..|..::....
Human   343 NGGLGVVSDAIFDL---GMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFE 404

  Fly   595 IYILNR-----HCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLK-NRKL--PKFLEEIWD 651
            .||..|     |        |:.|||..:|:||.:|..:|.....:|:: ..:|  |.|||...|
Human   405 HYINYRKHHVTH--------FWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 461

  Fly   652  651
            Human   462  461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	47/97 (48%)
		NR_LBD_EcR	420..652	CDD:132736	77/244 (32%)
THRB	NP_000452.2	Modulating	1..106		11/45 (24%)
		NR_DBD_TR	106..192	CDD:143519	43/85 (51%)
		NR_LBD_TR	216..458	CDD:132733	79/278 (28%)
		Interaction with NR2F6. /evidence=ECO:0000269|PubMed:10713182	244..461		74/228 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910